{"id":54474,"date":"2026-06-18T20:17:06","date_gmt":"2026-06-18T13:17:06","guid":{"rendered":"https:\/\/coffeefactz.com\/?p=54474"},"modified":"2026-09-12T10:50:44","modified_gmt":"2026-09-12T03:50:44","slug":"cafestol-va-kahweol-cholesterol-ca-phe","status":"publish","type":"post","link":"https:\/\/coffeefactz.com\/vi\/cafestol-va-kahweol-cholesterol-ca-phe\/","title":{"rendered":"Cafestol v\u00e0 kahweol: C\u00e1c diterpene l\u00e0m t\u0103ng cholesterol \u1ea9n trong c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc"},"content":{"rendered":"\n

Cafestol v\u00e0 kahweol, hai diterpene t\u1ef1 nhi\u00ean n\u1eb1m \u1ea9n s\u00e2u trong ph\u1ea7n d\u1ea7u c\u1ee7a c\u00e0 ph\u00ea, \u0111ang \u00e2m th\u1ea7m ch\u1ecbu tr\u00e1ch nhi\u1ec7m cho vi\u1ec7c l\u00e0m t\u0103ng cholesterol LDL nhi\u1ec1u h\u01a1n b\u1ea5t k\u1ef3 h\u1ee3p ch\u1ea5t n\u00e0o kh\u00e1c trong ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng c\u1ee7a con ng\u01b0\u1eddi. H\u1ea7u h\u1ebft nh\u1eefng ai u\u1ed1ng c\u00e0 ph\u00ea pha b\u00ecnh French press, espresso hay c\u00e0 ph\u00ea \u0111un s\u00f4i m\u1ed7i s\u00e1ng \u0111\u1ec1u kh\u00f4ng h\u1ec1 hay bi\u1ebft r\u1eb1ng h\u1ecd \u0111ang n\u1ea1p ch\u00fang v\u00e0o c\u01a1 th\u1ec3 v\u1edbi li\u1ec1u l\u01b0\u1ee3ng \u0111\u00e1ng k\u1ec3.<\/p>\n\n\n\n

Tin vui l\u00e0 \u0111\u00e2y l\u00e0 m\u1ed9t trong s\u1ed1 \u00edt nh\u1eefng r\u1ee7i ro cholesterol qua \u0111\u01b0\u1eddng \u0103n u\u1ed1ng c\u00f3 th\u1ec3 kh\u1eafc ph\u1ee5c v\u00f4 c\u00f9ng \u0111\u01a1n gi\u1ea3n – m\u00e0 ho\u00e0n to\u00e0n kh\u00f4ng b\u1eaft bu\u1ed9c b\u1ea1n ph\u1ea3i t\u1eeb b\u1ecf c\u00e0 ph\u00ea. Th\u1ea5u hi\u1ec3u nh\u1eefng h\u1ee3p ch\u1ea5t n\u00e0y l\u00e0m g\u00ec, ch\u00fang \u1ea9n n\u00e1u \u1edf \u0111\u00e2u v\u00e0 c\u01a1 th\u1ec3 ph\u1ea3n \u1ee9ng ra sao s\u1ebd cung c\u1ea5p cho b\u1ea1n m\u1ecdi c\u01a1 s\u1edf c\u1ea7n thi\u1ebft \u0111\u1ec3 \u0111\u01b0a ra l\u1ef1a ch\u1ecdn th\u1ef1c s\u1ef1 s\u00e1ng su\u1ed1t.<\/p>\n\n\n\n

Cafestol v\u00e0 Kahweol l\u00e0 g\u00ec?<\/h2>\n\n\n\n

Cafestol v\u00e0 kahweol l\u00e0 c\u00e1c diterpene t\u1ef1 nhi\u00ean tan trong ch\u1ea5t b\u00e9o, t\u1eadp trung \u1edf ph\u1ea7n d\u1ea7u c\u1ee7a h\u1ea1t c\u00e0 ph\u00ea – n\u1eb1m trong d\u1ea7u ch\u1ee9 kh\u00f4ng ph\u1ea3i trong n\u01b0\u1edbc – v\u00e0 ch\u00fang n\u1eafm gi\u1eef v\u1ecb th\u1ebf l\u00e0 nh\u1eefng t\u00e1c nh\u00e2n l\u00e0m t\u0103ng cholesterol LDL m\u1ea1nh nh\u1ea5t qua \u0111\u01b0\u1eddng \u0103n u\u1ed1ng m\u00e0 gi\u1edbi nghi\u00ean c\u1ee9u t\u1eebng ph\u00e1t hi\u1ec7n. Kh\u00f4ng c\u00f3 m\u1ed9t h\u1ee3p ch\u1ea5t \u0111\u01a1n l\u1ebb n\u00e0o trong th\u1ef1c ph\u1ea9m l\u00e0m t\u0103ng LDL huy\u1ebft thanh m\u1ed9t c\u00e1ch \u1ed5n \u0111\u1ecbnh v\u00e0 r\u00f5 r\u1ec7t \u0111\u1ebfn v\u1eady. M\u1ee5c ti\u00eau t\u00e1c \u0111\u1ed9ng ch\u00ednh c\u1ee7a ch\u00fang l\u00e0 cholesterol lipoprotein t\u1ef7 tr\u1ecdng th\u1ea5p (LDL) – lo\u1ea1i h\u1ea1t li\u00ean quan tr\u1ef1c ti\u1ebfp nh\u1ea5t \u0111\u1ebfn s\u1ef1 h\u00ecnh th\u00e0nh m\u1ea3ng x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch, trong khi t\u00e1c \u0111\u1ed9ng c\u1ee7a ch\u00fang l\u00ean HDL (lo\u1ea1i cholesterol “t\u1ed1t”) \u1edf m\u1ee9c t\u1ed1i thi\u1ec3u.<\/p>\n\n\n\n

V\u00ec cafestol v\u00e0 kahweol c\u00f3 t\u00ednh k\u1ef5 n\u01b0\u1edbc, ch\u00fang kh\u00f4ng h\u00f2a tan v\u00e0o ph\u1ea7n dung d\u1ecbch n\u01b0\u1edbc v\u1ed1n chi\u1ebfm ph\u1ea7n l\u1edbn th\u1ec3 t\u00edch t\u00e1ch c\u00e0 ph\u00ea c\u1ee7a b\u1ea1n. Ch\u00fang di chuy\u1ec3n c\u00f9ng c\u00e1c gi\u1ecdt d\u1ea7u. \u0110\u1eb7c t\u00ednh v\u1eadt l\u00fd duy nh\u1ea5t \u0111\u00f3 ch\u00ednh l\u00e0 l\u00fd do khi\u1ebfn ph\u01b0\u01a1ng ph\u00e1p pha c\u00e0 ph\u00ea t\u1ea1o n\u00ean s\u1ef1 kh\u00e1c bi\u1ec7t mang t\u00ednh quy\u1ebft \u0111\u1ecbnh: n\u1ebfu c\u00f3 m\u1ed9t m\u00e0ng l\u1ecdc c\u01a1 h\u1ecdc gi\u1eef l\u1ea1i c\u00e1c gi\u1ecdt d\u1ea7u \u0111\u00f3 tr\u01b0\u1edbc khi ch\u00fang ch\u1ea3y xu\u1ed1ng c\u1ed1c, c\u00e1c diterpene s\u1ebd b\u1ecb ch\u1eb7n l\u1ea1i c\u00f9ng v\u1edbi d\u1ea7u. N\u1ebfu kh\u00f4ng c\u00f3 g\u00ec c\u1ea3n tr\u1edf, b\u1ea1n s\u1ebd u\u1ed1ng tr\u1ecdn v\u1eb9n ch\u00fang.<\/p>\n\n\n\n

\u0110\u00e2y l\u00e0 nh\u1eefng g\u00ec di\u1ec5n ra trong th\u1ef1c t\u1ebf: Gi\u1ea5y l\u1ecdc – lo\u1ea1i d\u00f9ng trong m\u00e1y pha nh\u1ecf gi\u1ecdt ti\u00eau chu\u1ea9n v\u00e0 ph\u1ec5u pha pour-over – s\u1ebd gi\u1eef l\u1ea1i nh\u1eefng gi\u1ecdt d\u1ea7u \u0111\u00f3 tr\u00ean c\u00e1c s\u1ee3i cellulose c\u1ee7a gi\u1ea5y. Ng\u01b0\u1ee3c l\u1ea1i, m\u00e0ng kim lo\u1ea1i, v\u1ed1n l\u00e0 th\u1ee9 b\u00ecnh French press hay h\u1ea7u h\u1ebft m\u00e1y pha espresso s\u1eed d\u1ee5ng, cho ph\u00e9p d\u1ea7u \u0111i th\u1eb3ng qua. S\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa m\u1ed9t t\u00e1ch c\u00e0 ph\u00ea l\u1ecdc qua gi\u1ea5y v\u00e0 m\u1ed9t t\u00e1ch kh\u00f4ng l\u1ecdc kh\u00f4ng ch\u1ec9 d\u1eebng l\u1ea1i \u1edf s\u1edf th\u00edch h\u01b0\u01a1ng v\u1ecb. \u0110\u00f3 l\u00e0 s\u1ef1 kh\u00e1c bi\u1ec7t th\u1ef1c ch\u1ea5t v\u1ec1 g\u00e1nh n\u1eb7ng m\u00e0 l\u00e1 gan c\u1ee7a b\u1ea1n ph\u1ea3i x\u1eed l\u00fd m\u1ed7i bu\u1ed5i s\u00e1ng.<\/p>\n\n\n\n

H\u00e3y xem cafestol v\u00e0 kahweol th\u1ef1c s\u1ef1 tr\u00f4ng nh\u01b0 th\u1ebf n\u00e0o t\u1ea1i ngu\u1ed3n g\u1ed1c – n\u1eb1m s\u00e2u b\u00ean trong ch\u00ednh nh\u1eefng h\u1ea1t c\u00e0 ph\u00ea xu\u1ea5t hi\u1ec7n trong m\u1ecdi ph\u01b0\u01a1ng ph\u00e1p pha ch\u1ebf.<\/p>\n\n\n\n

\"Macro<\/figure>\n\n\n\n
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Ti\u1ebfn s\u0129 Carmine Ostacolo<\/strong><\/u><\/a>, Ph\u00f3 Gi\u00e1o s\u01b0 H\u00f3a D\u01b0\u1ee3c t\u1ea1i Khoa D\u01b0\u1ee3c, \u0110\u1ea1i h\u1ecdc Naples Federico II, nh\u1eadn \u0111\u1ecbnh r\u1eb1ng cafestol ch\u1ecbu tr\u00e1ch nhi\u1ec7m cho h\u01a1n 80% t\u1ed5ng t\u00e1c \u0111\u1ed9ng m\u00e0 c\u00e0 ph\u00ea g\u00e2y ra \u0111\u1ed1i v\u1edbi lipid huy\u1ebft thanh – m\u1ed9t con s\u1ed1 nh\u1ea5n m\u1ea1nh m\u1ee9c \u0111\u1ed9 \u00e1p \u0111\u1ea3o c\u1ee7a cafestol so v\u1edbi kahweol trong c\u00e2u chuy\u1ec7n n\u00e0y. Kahweol c\u00f3 \u0111\u00f3ng g\u00f3p m\u1ed9t ph\u1ea7n, nh\u01b0ng cafestol m\u1edbi l\u00e0 \u0111\u1ed9ng l\u1ef1c ch\u00ednh, v\u00e0 \u0111\u00f3 l\u00e0 h\u1ee3p ch\u1ea5t bi\u1ebfn c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc th\u00e0nh m\u1ed9t v\u1ea5n \u0111\u1ec1 cholesterol th\u1ef1c t\u1ebf ch\u1ee9 kh\u00f4ng c\u00f2n l\u00e0 l\u00fd thuy\u1ebft su\u00f4ng.<\/p>\n\n\n\n

\n\n\n\n

C\u00e1c ph\u01b0\u01a1ng ph\u00e1p pha: Ranh gi\u1edbi th\u1ef1c s\u1ef1 c\u1ee7a m\u00e0ng l\u1ecdc<\/h2>\n\n\n\n

C\u00e1c ph\u01b0\u01a1ng ph\u00e1p pha c\u00e0 ph\u00ea ph\u00e2n t\u00e1ch r\u00f5 r\u1ec7t th\u00e0nh hai nh\u00f3m khi x\u00e9t \u0111\u1ebfn m\u1ee9c \u0111\u1ed9 ph\u01a1i nhi\u1ec5m diterpene, v\u00e0 l\u1eb1n ranh ph\u00e2n \u0111\u1ecbnh kh\u00f4ng n\u1eb1m \u1edf n\u01a1i m\u00e0 h\u1ea7u h\u1ebft m\u1ecdi ng\u01b0\u1eddi l\u1ea7m t\u01b0\u1edfng. C\u00e1c ph\u01b0\u01a1ng ph\u00e1p d\u00f9ng gi\u1ea5y l\u1ecdc – m\u00e1y pha nh\u1ecf gi\u1ecdt ti\u00eau chu\u1ea9n d\u00f9ng ph\u1ec5u gi\u1ea5y, pour-over, Aeropress d\u00f9ng \u0111\u0129a gi\u1ea5y l\u1ecdc, v\u00e0 b\u00ecnh percolator l\u00f3t gi\u1ea5y – lo\u1ea1i b\u1ecf kho\u1ea3ng 98% cafestol v\u00e0 kahweol b\u1eb1ng c\u00e1ch gi\u1eef c\u00e1c gi\u1ecdt d\u1ea7u l\u1ea1i tr\u00ean s\u1ee3i gi\u1ea5y tr\u01b0\u1edbc khi ch\u00fang ch\u1ea3y v\u00e0o t\u00e1ch. T\u1ea5t c\u1ea3 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p c\u00f2n l\u1ea1i – French press, c\u00e0 ph\u00ea Th\u1ed5 Nh\u0129 K\u1ef3, c\u00e0 ph\u00ea Hy L\u1ea1p, c\u00e0 ph\u00ea \u0111un s\u00f4i ki\u1ec3u Scandinavia, \u1ea5m Moka, cold brew kh\u00f4ng l\u1ecdc l\u1ea1i qua gi\u1ea5y, v\u00e0 espresso – \u0111\u1ec1u \u0111\u01b0a c\u00e1c diterpene n\u00e0y v\u00e0o c\u01a1 th\u1ec3 v\u1edbi h\u00e0m l\u01b0\u1ee3ng \u0111o l\u01b0\u1eddng \u0111\u01b0\u1ee3c trong t\u1eebng l\u1ea7n u\u1ed1ng.<\/p>\n\n\n\n

Espresso th\u01b0\u1eddng khi\u1ebfn m\u1ecdi ng\u01b0\u1eddi nh\u1ea7m l\u1eabn v\u00ec dung t\u00edch ph\u1ee5c v\u1ee5 nh\u1ecf. M\u1ed9t shot \u0111\u00f4i (double shot) ch\u1ec9 kho\u1ea3ng 60 ml, n\u00ean li\u1ec1u l\u01b0\u1ee3ng tuy\u1ec7t \u0111\u1ed1i tr\u00ean m\u1ed7i t\u00e1ch th\u1ea5p h\u01a1n m\u1ed9t b\u00ecnh French press \u0111\u1ea7y – nh\u01b0ng c\u00e0 ph\u00ea v\u1eabn ch\u1ea3y qua l\u01b0\u1edbi kim lo\u1ea1i ch\u1ee9 kh\u00f4ng qua gi\u1ea5y, do \u0111\u00f3 c\u00e1c diterpene v\u1eabn hi\u1ec7n di\u1ec7n. N\u1ebfu b\u1ea1n u\u1ed1ng hai \u0111\u1ebfn ba shot \u0111\u00f4i m\u1ed7i ng\u00e0y, li\u1ec1u l\u01b0\u1ee3ng t\u00edch l\u0169y s\u1ebd tr\u1edf n\u00ean r\u1ea5t \u0111\u00e1ng k\u1ec3. Ng\u01b0\u1ee3c l\u1ea1i, c\u00e0 ph\u00ea h\u00f2a tan v\u1ec1 b\u1ea3n ch\u1ea5t l\u00e0 trung t\u00ednh v\u1edbi cholesterol: quy tr\u00ecnh s\u1ea3n xu\u1ea5t c\u00f4ng nghi\u1ec7p \u0111\u00e3 lo\u1ea1i b\u1ecf ph\u1ea7n d\u1ea7u, ch\u1ec9 \u0111\u1ec3 l\u1ea1i l\u01b0\u1ee3ng diterpene kh\u00f4ng \u0111\u00e1ng k\u1ec3.<\/p>\n\n\n\n

C\u00e1i b\u1eaby tinh vi h\u01a1n n\u1eb1m \u1edf ch\u00ednh t\u1eeb “\u0111\u00e3 l\u1ecdc” (filtered). Nhi\u1ec1u ng\u01b0\u1eddi m\u1eb7c \u0111\u1ecbnh r\u1eb1ng b\u1ea5t k\u1ef3 m\u00e1y pha n\u00e0o c\u00f3 gi\u1ecf l\u1ecdc \u0111\u1ec1u an to\u00e0n. Th\u1ef1c t\u1ebf kh\u00f4ng ph\u1ea3i v\u1eady. L\u01b0\u1edbi kim lo\u1ea1i v\u00e0 ph\u1ec5u l\u1ecdc nylon kh\u00f4ng th\u1ec3 li\u00ean k\u1ebft \u0111\u1ec3 gi\u1eef c\u00e1c lo\u1ea1i d\u1ea7u k\u1ef5 n\u01b0\u1edbc – ch\u00fang ch\u1ec9 gi\u1eef l\u1ea1i b\u00e3 c\u00e0 ph\u00ea th\u00f4. Ch\u1ea5t li\u1ec7u c\u1ee7a m\u00e0ng l\u1ecdc m\u1edbi l\u00e0 y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh, ch\u1ee9 kh\u00f4ng ph\u1ea3i s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a m\u1ed9t b\u1ed9 ph\u1eadn l\u1ecdc.<\/p>\n\n\n\n

B\u1ea3ng d\u01b0\u1edbi \u0111\u00e2y minh h\u1ecda s\u1ef1 bi\u1ebfn thi\u00ean r\u00f5 r\u1ec7t v\u1ec1 n\u1ed3ng \u0111\u1ed9 diterpene gi\u1eefa c\u00e1c ph\u01b0\u01a1ng ph\u00e1p pha – v\u00e0 gi\u1ea3i th\u00edch t\u1ea1i sao lo\u1ea1i m\u00e0ng l\u1ecdc l\u1ea1i l\u00e0 bi\u1ebfn s\u1ed1 mang t\u00ednh quy\u1ebft \u0111\u1ecbnh.<\/p>\n\n\n\n

Ph\u01b0\u01a1ng ph\u00e1p pha<\/th>Lo\u1ea1i m\u00e0ng l\u1ecdc<\/th>N\u1ed3ng \u0111\u1ed9 Cafestol (\u01b0\u1edbc t\u00ednh)<\/th>M\u1ee9c \u0111\u1ed9 ph\u01a1i nhi\u1ec5m Diterpene<\/th><\/tr><\/thead>
Pha nh\u1ecf gi\u1ecdt gi\u1ea5y \/ Pour-over<\/td>Gi\u1ea5y l\u1ecdc<\/td>~12 mg\/L<\/td>Kh\u00f4ng \u0111\u00e1ng k\u1ec3<\/td><\/tr>
Aeropress (d\u00f9ng \u0111\u0129a gi\u1ea5y)<\/td>Gi\u1ea5y l\u1ecdc<\/td>~12 mg\/L<\/td>Kh\u00f4ng \u0111\u00e1ng k\u1ec3<\/td><\/tr>
C\u00e0 ph\u00ea h\u00f2a tan<\/td>Kh\u00f4ng \u00e1p d\u1ee5ng (\u0111\u00e3 qua ch\u1ebf bi\u1ebfn)<\/td><5 mg\/L<\/td>Kh\u00f4ng \u0111\u00e1ng k\u1ec3<\/td><\/tr>
Espresso<\/td>L\u01b0\u1edbi kim lo\u1ea1i<\/td>~40\u201360 mg\/L<\/td>Trung b\u00ecnh (dung t\u00edch nh\u1ecf)<\/td><\/tr>
\u1ea4m Moka<\/td>M\u00e0ng l\u1ecdc kim lo\u1ea1i<\/td>~40\u201380 mg\/L<\/td>Trung b\u00ecnh<\/td><\/tr>
Cold brew (kh\u00f4ng qua gi\u1ea5y)<\/td>Kim lo\u1ea1i \/ nylon<\/td>~40\u2013100 mg\/L<\/td>Trung b\u00ecnh \u2013 Cao<\/td><\/tr>
French press<\/td>L\u01b0\u1edbi kim lo\u1ea1i<\/td>~100\u2013200 mg\/L<\/td>Cao<\/td><\/tr>
C\u00e0 ph\u00ea \u0111un s\u00f4i \/ Th\u1ed5 Nh\u0129 K\u1ef3 \/ Hy L\u1ea1p<\/td>Kh\u00f4ng c\u00f3<\/td>~150\u2013300 mg\/L<\/td>Cao<\/td><\/tr>
M\u00e1y pha l\u01b0\u1edbi kim lo\u1ea1i v\u0103n ph\u00f2ng<\/td>L\u01b0\u1edbi kim lo\u1ea1i<\/td>L\u00ean t\u1edbi 444 mg\/L<\/td>R\u1ea5t cao<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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D\u00f2ng cu\u1ed1i c\u00f9ng trong b\u1ea3ng r\u1ea5t \u0111\u00e1ng \u0111\u1ec3 l\u01b0u t\u00e2m. M\u1ed9t nghi\u00ean c\u1ee9u ph\u00e2n t\u00edch m\u00e1y pha c\u00e0 ph\u00ea t\u1ea1i c\u00e1c c\u00f4ng s\u1edf \u1edf Th\u1ee5y \u0110i\u1ec3n, \u0111\u01b0\u1ee3c tr\u00edch d\u1eabn b\u1edfi Ti\u1ebfn s\u0129 Maria Halvorsen<\/strong><\/u><\/a> v\u00e0 c\u00e1c c\u1ed9ng s\u1ef1 t\u1ea1i Khoa Dinh d\u01b0\u1ee1ng, Vi\u1ec7n Khoa h\u1ecdc Y t\u1ebf C\u01a1 b\u1ea3n, \u0110\u1ea1i h\u1ecdc Oslo, ph\u00e1t hi\u1ec7n r\u1eb1ng c\u00e1c m\u00e1y pha v\u0103n ph\u00f2ng d\u00f9ng l\u01b0\u1edbi kim lo\u1ea1i t\u1ea1o ra n\u1ed3ng \u0111\u1ed9 cafestol l\u00ean t\u1edbi 444 mg\/L – g\u1ea5p kho\u1ea3ng 37 l\u1ea7n m\u1ee9c 12 mg\/L \u0111i\u1ec3n h\u00ecnh c\u1ee7a c\u00e0 ph\u00ea l\u1ecdc gi\u1ea5y t\u1ea1i nh\u00e0, v\u1edbi m\u1ee9c trung v\u1ecb l\u00e0 176 mg\/L tr\u00ean c\u00e1c m\u00e1y kh\u1ea3o s\u00e1t. N\u1ebfu c\u00e0 ph\u00ea v\u0103n ph\u00f2ng c\u1ee7a b\u1ea1n ch\u1ea3y qua m\u1ed9t m\u00e1y pha th\u01b0\u01a1ng m\u1ea1i d\u00f9ng l\u01b0\u1edbi kim lo\u1ea1i v\u00e0 b\u1ea1n u\u1ed1ng ba t\u00e1ch m\u1ed7i ng\u00e0y, b\u1ea1n \u0111ang n\u1ea1p v\u00e0o c\u01a1 th\u1ec3 m\u1ed9t l\u01b0\u1ee3ng diterpene t\u01b0\u01a1ng \u0111\u01b0\u01a1ng b\u00ecnh French press m\u00e0 kh\u00f4ng h\u1ec1 hay bi\u1ebft. Nghi\u00ean c\u1ee9u c\u1ee7a Ti\u1ebfn s\u0129 Halvorsen c\u0169ng ghi nh\u1eadn r\u1eb1ng c\u00e0 ph\u00ea French press \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 kahweol t\u1edbi 17,2 mg m\u1ed7i t\u00e1ch v\u00e0 cafestol t\u1edbi 19,7 mg m\u1ed7i t\u00e1ch – thu\u1ed9c h\u00e0ng cao nh\u1ea5t trong c\u00e1c ph\u01b0\u01a1ng ph\u00e1p pha ph\u1ed5 bi\u1ebfn – trong khi m\u00e0ng l\u1ecdc gi\u1ea5y \u0111\u01b0a c\u1ea3 hai v\u1ec1 g\u1ea7n m\u1ee9c s\u1ed1 kh\u00f4ng.<\/p>\n\n\n\n

\u00dd ngh\u0129a th\u1ef1c ti\u1ec5n r\u1ea5t tr\u1ef1c di\u1ec7n: h\u00e3y ki\u1ec3m tra xem m\u00e1y pha c\u00e0 ph\u00ea c\u1ee7a b\u1ea1n th\u1ef1c s\u1ef1 d\u00f9ng ch\u1ea5t li\u1ec7u g\u00ec \u0111\u1ec3 l\u1ecdc, ch\u1ee9 kh\u00f4ng ch\u1ec9 nh\u00ecn v\u00e0o vi\u1ec7c n\u00f3 c\u00f3 m\u1ed9t khay l\u1ecdc hay kh\u00f4ng.<\/p>\n\n\n\n

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M\u1ee9c cholesterol c\u1ee7a b\u1ea1n th\u1ef1c s\u1ef1 c\u00f3 th\u1ec3 t\u0103ng bao nhi\u00eau?<\/h2>\n\n\n\n

Cholesterol huy\u1ebft thanh kh\u00f4ng ph\u1ea3n \u1ee9ng t\u1ee9c th\u00ec sau m\u1ed9t t\u00e1ch c\u00e0 ph\u00ea – n\u00f3 ph\u1ea3n \u1ee9ng v\u1edbi m\u1ed9t th\u00f3i quen t\u00edch l\u0169y k\u00e9o d\u00e0i, v\u00e0 m\u1ed1i quan h\u1ec7 gi\u1eefa li\u1ec1u l\u01b0\u1ee3ng v\u00e0 ph\u1ea3n \u1ee9ng (dose-response) c\u1ee7a cafestol l\u00e0 m\u1ed9t trong nh\u1eefng \u0111\u1eb7c t\u00ednh \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 chu\u1ea9n x\u00e1c nh\u1ea5t trong nghi\u00ean c\u1ee9u dinh d\u01b0\u1ee1ng. Ti\u00eau th\u1ee5 kho\u1ea3ng 60 mg cafestol m\u1ed7i ng\u00e0y – t\u01b0\u01a1ng \u0111\u01b0\u01a1ng l\u01b0\u1ee3ng c\u00f3 trong kho\u1ea3ng 5 t\u00e1ch c\u00e0 ph\u00ea French press – l\u00e0m t\u0103ng cholesterol LDL kho\u1ea3ng 0,57 mmol\/L (x\u1ea5p x\u1ec9 22 mg\/dL) trong c\u00e1c th\u1eed nghi\u1ec7m c\u00f3 \u0111\u1ed1i ch\u1ee9ng k\u00e9o d\u00e0i b\u1ed1n tu\u1ea7n. \u0110\u00f3 kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t s\u1ef1 d\u1ecbch chuy\u1ec3n nh\u1ecf. \u0110\u1ec3 d\u1ec5 h\u00ecnh dung, th\u00f3i quen u\u1ed1ng 2\u20133 t\u00e1ch c\u00e0 ph\u00ea French press ho\u1eb7c c\u00e0 ph\u00ea \u0111un s\u00f4i m\u1ed7i ng\u00e0y th\u01b0\u1eddng \u0111\u1ea9y m\u1ee9c LDL t\u0103ng th\u00eam 8\u201310 mg\/dL, v\u00e0 u\u1ed1ng nhi\u1ec1u h\u01a1n s\u1ebd \u0111\u1ea9y con s\u1ed1 n\u00e0y l\u00ean cao h\u01a1n n\u1eefa.<\/p>\n\n\n\n

\u0110\u1ec3 hi\u1ec3u t\u1ea1i sao \u0111i\u1ec1u n\u00e0y c\u00f3 \u00fd ngh\u0129a v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng, h\u00e3y x\u00e9t tr\u01b0\u1eddng h\u1ee3p ng\u01b0\u1ee3c l\u1ea1i: gi\u1ea3m 1 mmol\/L LDL c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c gi\u1ea3m kho\u1ea3ng 22% nguy c\u01a1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch nghi\u00eam tr\u1ecdng. Ph\u00e9p t\u00ednh n\u00e0y c\u0169ng v\u1eadn h\u00e0nh t\u01b0\u01a1ng t\u1ef1 theo chi\u1ec1u h\u01b0\u1edbng ng\u01b0\u1ee3c l\u1ea1i. S\u1ef1 gia t\u0103ng khi\u00eam t\u1ed1n nh\u01b0ng k\u00e9o d\u00e0i c\u1ee7a LDL t\u1eeb th\u00f3i quen u\u1ed1ng c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc h\u00e0ng ng\u00e0y kh\u00f4ng g\u00e2y th\u1ea3m h\u1ecda ngay l\u1eadp t\u1ee9c khi \u0111\u1ee9ng ri\u00eang l\u1ebb, nh\u01b0ng n\u00f3 l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 nguy c\u01a1 th\u1ef1c s\u1ef1 c\u00f3 th\u1ec3 can thi\u1ec7p \u0111\u01b0\u1ee3c – v\u00e0 n\u00f3 c\u1ed9ng h\u01b0\u1edfng v\u1edbi c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 kh\u00e1c.<\/p>\n\n\n\n

M\u1ed9t th\u1eed nghi\u1ec7m c\u00f3 \u0111\u1ed1i ch\u1ee9ng c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed European Journal of Clinical Nutrition<\/em><\/strong><\/u><\/a> \u0111\u00e3 ch\u1ee9ng minh tr\u1ef1c ti\u1ebfp m\u1ed1i quan h\u1ec7 li\u1ec1u l\u01b0\u1ee3ng – ph\u1ea3n \u1ee9ng n\u00e0y, cho th\u1ea5y m\u1ee9c t\u0103ng LDL do cafestol l\u00e0 c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n v\u00e0 l\u1eb7p l\u1ea1i tr\u00ean nhi\u1ec1u \u0111\u1ed1i t\u01b0\u1ee3ng, ch\u1ee9 kh\u00f4ng ch\u1ec9 l\u00e0 m\u1ed9t sai s\u1ed1 th\u1ed1ng k\u00ea t\u1eeb m\u1ed9t nh\u00f3m nghi\u00ean c\u1ee9u c\u00e1 bi\u1ec7t.<\/p>\n\n\n\n

D\u1eef li\u1ec7u c\u1ea5p \u0111\u1ed9 qu\u1ea7n th\u1ec3 c\u0169ng c\u1ee7ng c\u1ed1 b\u1ee9c tranh n\u00e0y. Kh\u1ea3o s\u00e1t Troms\u00f8 – m\u1ed9t nghi\u00ean c\u1ee9u thu\u1ea7n t\u1eadp quy m\u00f4 l\u1edbn t\u1ea1i Na Uy – ph\u00e1t hi\u1ec7n ra r\u1eb1ng nh\u1eefng ng\u01b0\u1eddi u\u1ed1ng t\u1eeb ba \u0111\u1ebfn n\u0103m t\u00e1ch espresso m\u1ed7i ng\u00e0y c\u00f3 s\u1ef1 gia t\u0103ng \u0111o l\u01b0\u1eddng \u0111\u01b0\u1ee3c v\u1ec1 cholesterol to\u00e0n ph\u1ea7n trong huy\u1ebft thanh, v\u1edbi t\u00e1c \u0111\u1ed9ng tr\u1edf n\u00ean r\u00f5 r\u1ec7t h\u01a1n \u1edf c\u00e1c m\u1ee9c ti\u00eau th\u1ee5 cao h\u01a1n. \u0110\u00e2y l\u00e0 b\u1eb1ng ch\u1ee9ng th\u1ef1c t\u1ebf kh\u1eb3ng \u0111\u1ecbnh c\u00e1c s\u1ed1 li\u1ec7u th\u1eed nghi\u1ec7m c\u00f3 \u0111\u1ed1i ch\u1ee9ng ho\u00e0n to\u00e0n chuy\u1ec3n h\u00f3a ra ngo\u00e0i \u0111\u1eddi s\u1ed1ng th\u1ef1c t\u1ebf.<\/p>\n\n\n\n

C\u00f3 hai l\u01b0u \u00fd quan tr\u1ecdng c\u1ea7n ghi nh\u1edb: Th\u1ee9 nh\u1ea5t, t\u00e1c \u0111\u1ed9ng n\u00e0y ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u l\u01b0\u1ee3ng v\u00e0 kh\u00f4ng mang t\u00ednh v\u0129nh vi\u1ec5n: chuy\u1ec3n sang c\u00e0 ph\u00ea l\u1ecdc gi\u1ea5y gi\u00fap m\u1ee9c cholesterol tr\u1edf v\u1ec1 \u0111\u01b0\u1eddng c\u01a1 s\u1edf ban \u0111\u1ea7u trong v\u00f2ng v\u00e0i tu\u1ea7n, \u0111\u1ed3ng ngh\u0129a \u0111\u00e2y l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 nguy c\u01a1 ho\u00e0n to\u00e0n c\u00f3 th\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c. Th\u1ee9 hai – v\u00e0 \u0111\u00e2y l\u00e0 kho\u1ea3ng tr\u1ed1ng trong b\u1eb1ng ch\u1ee9ng hi\u1ec7n t\u1ea1i – ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u n\u00e0o chuy\u1ec3n h\u00f3a tr\u1ef1c ti\u1ebfp m\u1ee9c t\u0103ng LDL n\u00e0y th\u00e0nh ch\u1ec9 s\u1ed1 nguy c\u01a1 tim m\u1ea1ch tuy\u1ec7t \u0111\u1ed1i cho t\u1eebng c\u00e1 nh\u00e2n. C\u00e1c d\u1ef1 ph\u00f3ng nguy c\u01a1 t\u01b0\u01a1ng \u0111\u1ed1i \u0111\u00e3 t\u1ed3n t\u1ea1i (m\u1ed9t ph\u00e2n t\u00edch \u01b0\u1edbc t\u00ednh nguy c\u01a1 t\u1eed vong do tim m\u1ea1ch gi\u1ea3m 13% sau n\u0103m n\u0103m n\u1ebfu ng\u01b0\u1eddi d\u00e2n chuy\u1ec3n t\u1eeb c\u00e0 ph\u00ea \u0111un s\u00f4i sang c\u00e0 ph\u00ea l\u1ecdc gi\u1ea5y), nh\u01b0ng n\u1ebfu kh\u00f4ng c\u00f3 \u0111\u01b0\u1eddng c\u01a1 s\u1edf tuy\u1ec7t \u0111\u1ed1i g\u1eafn li\u1ec1n v\u1edbi h\u1ed3 s\u01a1 r\u1ee7i ro c\u00e1 nh\u00e2n c\u1ee7a b\u1ea1n, b\u1ea1n kh\u00f4ng th\u1ec3 t\u00ednh to\u00e1n m\u1ed9t ph\u01b0\u01a1ng tr\u00ecnh ch\u00ednh x\u00e1c cho ri\u00eang m\u00ecnh. \u0110i\u1ec1u b\u1ea1n c\u00f3 th\u1ec3 l\u00e0m l\u00e0 xem s\u1ef1 gia t\u0103ng LDL nh\u01b0 m\u1ed9t t\u00edn hi\u1ec7u th\u1ef1c t\u1ebf v\u00e0 c\u00e2n nh\u1eafc n\u00f3 c\u00f9ng b\u1ee9c tranh tim m\u1ea1ch t\u1ed5ng th\u1ec3 – ti\u1ec1n s\u1eed gia \u0111\u00ecnh, ch\u1ec9 s\u1ed1 m\u1ee1 m\u00e1u n\u1ec1n, ch\u1ebf \u0111\u1ed9 \u0103n, m\u1ee9c \u0111\u1ed9 v\u1eadn \u0111\u1ed9ng – thay v\u00ec ch\u1ec9 nh\u00ecn nh\u1eadn n\u00f3 m\u1ed9t c\u00e1ch c\u00f4 l\u1eadp.<\/p>\n\n\n\n

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Cafestol chi\u1ebfm quy\u1ec1n ki\u1ec3m so\u00e1t h\u1ec7 th\u1ed1ng \u0111i\u1ec1u h\u00f2a cholesterol ra sao?<\/h2>\n\n\n\n

C\u00e1c th\u1ee5 th\u1ec3 LDL (LDL receptor) tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o gan l\u00e0 c\u01a1 ch\u1ebf ch\u00ednh c\u1ee7a c\u01a1 th\u1ec3 \u0111\u1ec3 d\u1ecdn d\u1eb9p c\u00e1c h\u1ea1t LDL ra kh\u1ecfi m\u1ea1ch m\u00e1u. Khi ho\u1ea1t \u0111\u1ed9ng b\u00ecnh th\u01b0\u1eddng, c\u00e1c th\u1ee5 th\u1ec3 n\u00e0y s\u1ebd t\u00f3m l\u1ea5y LDL \u0111ang tu\u1ea7n ho\u00e0n v\u00e0 k\u00e9o n\u00f3 v\u00e0o trong gan \u0111\u1ec3 x\u1eed l\u00fd – gi\u00fap gi\u1eef cho m\u1ee9c LDL trong m\u00e1u lu\u00f4n \u1edf ng\u01b0\u1ee1ng an to\u00e0n. Cafestol can thi\u1ec7p tr\u1ef1c ti\u1ebfp v\u00e0o h\u1ec7 th\u1ed1ng n\u00e0y b\u1eb1ng c\u00e1ch l\u00e0m gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng c\u1ee7a th\u1ee5 th\u1ec3 LDL, \u0111\u1ed3ng ngh\u0129a v\u1edbi vi\u1ec7c c\u00f3 \u00edt th\u1ee5 th\u1ec3 h\u01a1n tr\u00ean b\u1ec1 m\u1eb7t gan, \u00edt h\u1ea1t LDL \u0111\u01b0\u1ee3c d\u1ecdn d\u1eb9p h\u01a1n, v\u00e0 l\u01b0\u1ee3ng LDL trong m\u00e1u s\u1ebd t\u0103ng v\u1ecdt.<\/p>\n\n\n\n

\u0110i\u1ec1u khi\u1ebfn c\u01a1 ch\u1ebf c\u1ee7a cafestol tr\u1edf n\u00ean tinh vi b\u1ea5t th\u01b0\u1eddng l\u00e0 v\u1ecb tr\u00ed m\u00e0 n\u00f3 can thi\u1ec7p trong chu tr\u00ecnh. Nghi\u00ean c\u1ee9u tr\u00ean t\u1ebf b\u00e0o nguy\u00ean b\u00e0o s\u1ee3i da ng\u01b0\u1eddi ch\u1ec9 ra r\u1eb1ng cafestol l\u00e0m gi\u1ea3m m\u1ee9c protein th\u1ee5 th\u1ec3 LDL m\u00e0 kh\u00f4ng h\u1ec1 l\u00e0m thay \u0111\u1ed5i ARN th\u00f4ng tin (mRNA) c\u1ee7a th\u1ee5 th\u1ec3 – v\u1ed1n l\u00e0 b\u1ea3n ch\u1ec9 d\u1eabn di truy\u1ec1n m\u00e3 h\u00f3a cho protein. \u0110\u00e2y l\u00e0 c\u01a1 ch\u1ebf \u1ee9c ch\u1ebf sau phi\u00ean m\u00e3 (post-transcriptional down-regulation): gien di truy\u1ec1n v\u1eabn \u0111\u01b0\u1ee3c \u0111\u1ecdc b\u00ecnh th\u01b0\u1eddng, nh\u01b0ng qu\u00e1 tr\u00ecnh l\u1eafp r\u00e1p protein th\u1ee5 th\u1ec3 l\u1ea1i b\u1ecb ph\u00e1 v\u1ee1 \u1edf giai \u0111o\u1ea1n h\u1ea1 ngu\u1ed3n. N\u00f3 kh\u00f4ng ch\u1eb7n b\u1ea3n thi\u1ebft k\u1ebf; n\u00f3 ph\u00e1 ho\u1ea1i \u0111\u1ed9i ng\u0169 thi c\u00f4ng.<\/p>\n\n\n\n

M\u1ed9t nghi\u00ean c\u1ee9u ph\u1ea3n bi\u1ec7n khoa h\u1ecdc v\u1ec1 t\u00e1c \u0111\u1ed9ng c\u1ee7a cafestol tr\u00ean nguy\u00ean b\u00e0o s\u1ee3i da ng\u01b0\u1eddi<\/strong><\/u><\/a> ph\u00e1t hi\u1ec7n ra r\u1eb1ng vi\u1ec7c nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o v\u1edbi cafestol \u1edf n\u1ed3ng \u0111\u1ed9 20 \u00b5g\/mL trong 18 gi\u1edd \u0111\u00e3 l\u00e0m gi\u1ea3m l\u01b0\u1ee3ng protein th\u1ee5 th\u1ec3 LDL kho\u1ea3ng 20\u201325% trong khi mRNA th\u1ee5 th\u1ec3 v\u1eabn kh\u00f4ng \u0111\u1ed5i – b\u1eb1ng ch\u1ee9ng tr\u1ef1c ti\u1ebfp c\u1ee7a c\u01a1 ch\u1ebf sau phi\u00ean m\u00e3. Trong c\u00f9ng c\u00e1c t\u1ebf b\u00e0o \u0111\u00f3, cafestol l\u00e0m t\u0103ng s\u1ef1 k\u1ebft h\u1ee3p este cholesteryl l\u00ean 2,3 l\u1ea7n, cho th\u1ea5y qu\u00e1 tr\u00ecnh l\u01b0u tr\u1eef cholesterol n\u1ed9i b\u00e0o c\u0169ng b\u1ecb bi\u1ebfn \u0111\u1ed5i \u0111\u1ed3ng th\u1eddi.<\/p>\n\n\n\n

M\u1ed9t nghi\u00ean c\u1ee9u song song tr\u00ean t\u1ebf b\u00e0o gan HepG2<\/strong><\/u><\/a> \u0111\u00e3 x\u00e1c nh\u1eadn s\u1ef1 \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 LDL sau phi\u00ean m\u00e3 trong m\u00f4 gan, m\u1eb7c d\u00f9 n\u00f3 ch\u1ec9 ra r\u1eb1ng hi\u1ec7u \u1ee9ng este cholesteryl mang t\u00ednh \u0111\u1eb7c th\u00f9 theo t\u1eebng lo\u1ea1i t\u1ebf b\u00e0o – l\u1eddi nh\u1eafc nh\u1edf r\u1eb1ng c\u00e1c ph\u00e1t hi\u1ec7n c\u01a1 ch\u1ebf t\u1eeb m\u1ed9t m\u00f4 h\u00ecnh t\u1ebf b\u00e0o kh\u00f4ng ph\u1ea3i l\u00fac n\u00e0o c\u0169ng chuy\u1ec3n giao \u0111\u1ed3ng nh\u1ea5t sang m\u1ecdi m\u00f4.<\/p>\n\n\n\n

K\u1ebft qu\u1ea3 r\u00f2ng l\u00e0 m\u1ed9t b\u00e1nh c\u00f3c m\u1ed9t chi\u1ec1u: vi\u1ec7c thanh th\u1ea3i LDL kh\u1ecfi m\u00e1u gi\u1ea3m \u0111i k\u1ebft h\u1ee3p v\u1edbi vi\u1ec7c x\u1eed l\u00fd cholesterol n\u1ed9i b\u00e0o b\u1ecb bi\u1ebfn \u0111\u1ed5i. \u0110\u00e2y l\u00e0 l\u00fd do t\u1ea1i sao t\u00e1c \u0111\u1ed9ng c\u1ee7a cafestol t\u00edch l\u0169y qua nhi\u1ec1u ng\u00e0y \u0111\u1ebfn nhi\u1ec1u tu\u1ea7n ch\u1ee9 kh\u00f4ng b\u1ed9c l\u1ed9 ngay sau m\u1ed9t t\u00e1ch c\u00e0 ph\u00ea \u0111\u01a1n l\u1ebb – s\u1ef1 \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 t\u00edch t\u1ee5 d\u1ea7n d\u1ea7n, kh\u1edbp ho\u00e0n to\u00e0n v\u1edbi ti\u1ebfn tr\u00ecnh th\u1eddi gian quan s\u00e1t \u0111\u01b0\u1ee3c trong c\u00e1c th\u1eed nghi\u1ec7m tr\u00ean ng\u01b0\u1eddi.<\/p>\n\n\n\n

Gi\u00e1o s\u01b0 Y khoa Christian A. Drevon<\/strong><\/u><\/a>, nh\u00e0 nghi\u00ean c\u1ee9u h\u00e0ng \u0111\u1ea7u v\u1ec1 chuy\u1ec3n h\u00f3a lipid t\u1ea1i Khoa Dinh d\u01b0\u1ee1ng, \u0110\u1ea1i h\u1ecdc Oslo, ch\u1ec9 ra m\u1ed9t t\u1ea7ng c\u01a1 ch\u1ebf b\u1ed5 sung: vi\u1ec7c cafestol \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p axit m\u1eadt d\u01b0\u1eddng nh\u01b0 l\u00e0 m\u1ed9t ph\u1ea7n nguy\u00ean nh\u00e2n k\u00edch ho\u1ea1t s\u1ef1 suy gi\u1ea3m th\u1ee5 th\u1ec3 LDL. Axit m\u1eadt \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb cholesterol trong gan, v\u00e0 khi qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p c\u1ee7a ch\u00fang b\u1ecb \u1ee9c ch\u1ebf, v\u00f2ng ph\u1ea3n h\u1ed3i b\u00ecnh th\u01b0\u1eddng c\u1ee7a gan \u0111\u1ec3 qu\u1ea3n l\u00fd l\u01b0u th\u00f4ng cholesterol b\u1ecb gi\u00e1n \u0111o\u1ea1n – l\u00e0m t\u0103ng th\u00eam t\u00e1c \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp l\u00ean th\u1ee5 th\u1ec3. \u0110\u00e2y l\u00e0 l\u00fd do t\u1ea1i sao cafestol kh\u00e1c bi\u1ec7t ho\u00e0n to\u00e0n v\u1edbi c\u00e1c t\u00e1c nh\u00e2n cholesterol t\u1eeb ch\u1ebf \u0111\u1ed9 \u0103n kh\u00e1c; n\u00f3 kh\u00f4ng \u0111\u01a1n thu\u1ea7n b\u1ed5 sung th\u00eam cholesterol v\u00e0o h\u1ec7 th\u1ed1ng, m\u00e0 n\u00f3 l\u00e0m suy y\u1ebfu ch\u00ednh n\u0103ng l\u1ef1c t\u1ef1 qu\u1ea3n l\u00fd l\u01b0\u1ee3ng cholesterol s\u1eb5n c\u00f3 c\u1ee7a c\u01a1 th\u1ec3.<\/p>\n\n\n\n

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L\u1ee3i \u00edch ti\u1ec1m \u1ea9n: T\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 c\u1ee7a Cafestol v\u00e0 Kahweol<\/h2>\n\n\n\n

T\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7<\/u><\/b><\/a> c\u1ee7a cafestol v\u00e0 kahweol \u0111\u1ea1i di\u1ec7n cho m\u1ed9t trong nh\u1eefng ngh\u1ecbch l\u00fd \u0111\u00e1ng ng\u1ea1c nhi\u00ean trong h\u00f3a sinh dinh d\u01b0\u1ee1ng – ch\u00ednh nh\u1eefng h\u1ee3p ch\u1ea5t l\u00e0m t\u0103ng cholesterol LDL m\u1ed9t c\u00e1ch \u1ed5n \u0111\u1ecbnh l\u1ea1i b\u1ed9c l\u1ed9 ho\u1ea1t t\u00ednh ch\u1ed1ng vi\u00eam, ch\u1ed1ng oxy h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 gan r\u00f5 r\u1ec7t trong c\u00e1c m\u00f4 h\u00ecnh ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 \u0111\u1ed9ng v\u1eadt. \u0110\u00e2y kh\u00f4ng ph\u1ea3i ph\u00e1t hi\u1ec7n c\u00e1 bi\u1ec7t. N\u00f3 l\u00e0 m\u1ed9t ph\u1ea7n l\u00fd do gi\u1ea3i th\u00edch t\u1ea1i sao c\u00e1c nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec5 h\u1ecdc d\u00e2n s\u1ed1 li\u00ean t\u1ee5c g\u1eafn vi\u1ec7c u\u1ed1ng c\u00e0 ph\u00ea – bao g\u1ed3m c\u1ea3 c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc – v\u1edbi t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh gan th\u1ea5p h\u01a1n, gi\u1ea3m m\u1ed9t s\u1ed1 b\u1ec7nh ung th\u01b0 v\u00e0 c\u1ea3i thi\u1ec7n c\u00e1c ch\u1ec9 s\u1ed1 vi\u00eam m\u1ea1n t\u00ednh, ngay c\u1ea3 khi d\u1eef li\u1ec7u cholesterol d\u01b0\u1eddng nh\u01b0 ch\u1ec9 ra \u0111i\u1ec1u ng\u01b0\u1ee3c l\u1ea1i.<\/p>\n\n\n\n

B\u1ee9c tranh c\u01a1 ch\u1ebf, \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p b\u1edfi Ti\u1ebfn s\u0129 Christophe Cavin<\/strong><\/u><\/a>, Nh\u00e0 khoa h\u1ecdc Nghi\u00ean c\u1ee9u C\u1ea5p cao v\u1ec1 \u0110\u1ed9c h\u1ecdc v\u00e0 H\u00f3a d\u1ef1 ph\u00f2ng t\u1ea1i Trung t\u00e2m Nghi\u00ean c\u1ee9u Nestl\u00e9 \u1edf Lausanne, Th\u1ee5y S\u0129, bao g\u1ed3m nhi\u1ec1u con \u0111\u01b0\u1eddng ri\u00eang bi\u1ec7t v\u1eadn h\u00e0nh song song. Cafestol v\u00e0 kahweol l\u00e0m gi\u1ea3m c\u00e1c ch\u1ea5t trung gian g\u00e2y vi\u00eam – bao g\u1ed3m c\u00e1c con \u0111\u01b0\u1eddng t\u1ed5ng h\u1ee3p prostaglandin – t\u1ea1o ra ho\u1ea1t t\u00ednh kh\u00e1ng vi\u00eam \u0111o l\u01b0\u1eddng \u0111\u01b0\u1ee3c. Ch\u00fang l\u00e0m t\u0103ng glutathione, m\u1ed9t trong nh\u1eefng ch\u1ea5t ch\u1ed1ng oxy h\u00f3a n\u1ed9i sinh h\u00e0ng \u0111\u1ea7u c\u1ee7a gan, \u0111\u00e2y c\u00f3 th\u1ec3 l\u00e0 \u0111\u1ed9ng l\u1ef1c th\u00fac \u0111\u1ea9y t\u00edn hi\u1ec7u b\u1ea3o v\u1ec7 gan c\u1ee7a ch\u00fang. Trong c\u00e1c m\u00f4 h\u00ecnh t\u1ebf b\u00e0o ung th\u01b0, ch\u00fang k\u00edch ho\u1ea1t qu\u00e1 tr\u00ecnh t\u1ef1 h\u1ee7y apoptosis – ch\u1ebft t\u1ebf b\u00e0o theo ch\u01b0\u01a1ng tr\u00ecnh – \u1edf c\u00e1c d\u00f2ng t\u1ebf b\u00e0o kh\u1ed1i u v\u00e0 d\u01b0\u1eddng nh\u01b0 \u1ee9c ch\u1ebf s\u1ef1 h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u m\u1edbi (angiogenesis) m\u00e0 kh\u1ed1i u c\u1ea7n \u0111\u1ec3 ph\u00e1t tri\u1ec3n. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u c\u0169ng ch\u1ec9 ra t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, c\u00f3 th\u1ec3 th\u00f4ng qua c\u00e1c c\u01a1 ch\u1ebf li\u00ean quan \u0111\u1ebfn \u0111\u1ed9 nh\u1ea1y insulin, m\u1eb7c d\u00f9 b\u1eb1ng ch\u1ee9ng n\u00e0y c\u00f2n s\u01a1 khai.<\/p>\n\n\n\n

D\u01b0\u1edbi \u0111\u00e2y l\u00e0 c\u00e1ch th\u1ee9c d\u1eef li\u1ec7u ph\u1ea3n \u00e1nh khi b\u1ea1n \u0111\u1eb7t c\u00e1c ho\u1ea1t t\u00ednh b\u1ea3o v\u1ec7 n\u00e0y song song v\u1edbi r\u1ee7i ro cholesterol:<\/p>\n\n\n\n

\"Infographic<\/figure>\n\n\n\n
<\/div>\n\n\n\n

L\u01b0u \u00fd quan tr\u1ecdng l\u00e0 ph\u1ea7n l\u1edbn c\u00e1c b\u1eb1ng ch\u1ee9ng b\u1ea3o v\u1ec7 n\u00e0y \u0111\u1ebfn t\u1eeb nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o v\u00e0 m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt. C\u00e1c th\u1eed nghi\u1ec7m ng\u1eabu nhi\u00ean c\u00f3 \u0111\u1ed1i ch\u1ee9ng tr\u00ean ng\u01b0\u1eddi v\u1ec1 t\u00e1c d\u1ee5ng c\u00f3 l\u1ee3i c\u1ee7a cafestol v\u00e0 kahweol c\u00f2n r\u1ea5t khan hi\u1ebfm – c\u1ea5p \u0111\u1ed9 b\u1eb1ng ch\u1ee9ng \u0111\u01a1n gi\u1ea3n l\u00e0 th\u1ea5p h\u01a1n so v\u1edbi d\u1eef li\u1ec7u cholesterol, v\u1ed1n c\u00f3 n\u1ec1n t\u1ea3ng th\u1eed nghi\u1ec7m v\u1eefng ch\u1eafc tr\u00ean ng\u01b0\u1eddi. \u0110\u00e2y kh\u00f4ng ph\u1ea3i hai kh\u1ed1i b\u1eb1ng ch\u1ee9ng t\u01b0\u01a1ng \u0111\u01b0\u01a1ng, v\u00e0 s\u1ebd l\u00e0 sai l\u1ea7m n\u1ebfu coi nh\u01b0 ch\u00fang t\u1ef1 \u0111\u1ed9ng tri\u1ec7t ti\u00eau l\u1eabn nhau.<\/p>\n\n\n\n

B\u00ean c\u1ea1nh cafestol, c\u00e0 ph\u00ea c\u00f2n ch\u1ee9a axit chlorogenic trong c\u00e0 ph\u00ea<\/u><\/b><\/a>, m\u1ed9t polyphenol c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng oxy h\u00f3a v\u00e0 chuy\u1ec3n h\u00f3a \u0111\u00e1ng ch\u00fa \u00fd.<\/p>\n\n\n\n

Nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y gi\u00fap tr\u00e1nh m\u1ed9t c\u00e1i nh\u00ecn phi\u1ebfn di\u1ec7n m\u1ed9t chi\u1ec1u. N\u1ebfu b\u1ea1n u\u1ed1ng c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc h\u00e0ng ng\u00e0y nh\u01b0ng c\u00f3 m\u1ee9c cholesterol ho\u00e0n to\u00e0n b\u00ecnh th\u01b0\u1eddng, c\u00f3 ti\u1ec1n s\u1eed gia \u0111\u00ecnh m\u1eafc b\u1ec7nh gan, ho\u1eb7c m\u1eafc c\u00e1c b\u1ec7nh vi\u00eam m\u1ea1n t\u00ednh, ph\u00e9p t\u00ednh c\u00e2n nh\u1eafc r\u1ee7i ro – l\u1ee3i \u00edch c\u1ee7a b\u1ea1n s\u1ebd r\u1ea5t kh\u00e1c so v\u1edbi m\u1ed9t ng\u01b0\u1eddi c\u00f3 m\u1ed1i b\u1eadn t\u00e2m h\u00e0ng \u0111\u1ea7u l\u00e0 ch\u1ec9 s\u1ed1 LDL \u0111ang \u1edf ng\u01b0\u1ee1ng b\u00e1o \u0111\u1ed9ng. C\u00e1c diterpene kh\u00f4ng ho\u00e0n to\u00e0n c\u00f3 h\u1ea1i – ch\u00fang l\u00e0 nh\u1eefng h\u1ee3p ch\u1ea5t sinh h\u1ecdc ph\u1ee9c t\u1ea1p ph\u1ee5 thu\u1ed9c v\u00e0o t\u1eebng ng\u1eef c\u1ea3nh c\u1ee5 th\u1ec3. Vi\u1ec7c ghi nh\u1eadn s\u1ef1 ph\u1ee9c t\u1ea1p \u0111\u00f3 l\u00e0 \u0111i\u1ec1u c\u1ea7n thi\u1ebft khi b\u1ea1n \u0111\u01b0a ra quy\u1ebft \u0111\u1ecbnh c\u00e1 nh\u00e2n, ngay c\u1ea3 khi khoa h\u1ecdc ch\u01b0a \u0111\u01b0a ra m\u1ed9t \u0111i\u1ec3m s\u1ed1 r\u1ee7i ro – l\u1ee3i \u00edch tuy\u1ec7t \u0111\u1ed1i r\u00f5 r\u00e0ng.<\/p>\n\n\n\n

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Khi c\u00e0 ph\u00ea tr\u1edf th\u00e0nh c\u00fa \u0111\u00f2n k\u00e9p cho Cholesterol: Ch\u1ea5t b\u00e9o b\u1ed5 sung v\u00e0 s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1edbi t\u00ednh<\/h2>\n\n\n\n

C\u00e1c y\u1ebfu t\u1ed1 khu\u1ebfch \u0111\u1ea1i cholesterol trong c\u00e0 ph\u00ea hi\u1ebfm khi xu\u1ea5t hi\u1ec7n trong c\u00e1c h\u01b0\u1edbng d\u1eabn \u0103n u\u1ed1ng ti\u00eau chu\u1ea9n, nh\u01b0ng hai trong s\u1ed1 ch\u00fang – ch\u1ea5t b\u00e9o b\u00e3o h\u00f2a b\u1ed5 sung v\u00e0 ph\u1ea3n \u1ee9ng LDL \u0111\u1eb7c th\u00f9 theo gi\u1edbi t\u00ednh – c\u00f3 th\u1ec3 l\u00e0m thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 m\u1ee9c \u0111\u1ed9 r\u1ee7i ro th\u1ef1c t\u1ebf c\u1ee7a th\u00f3i quen u\u1ed1ng c\u00e0 ph\u00ea. Hi\u1ec3u r\u00f5 c\u1ea3 hai y\u1ebfu t\u1ed1 s\u1ebd mang l\u1ea1i cho b\u1ea1n c\u00e1i nh\u00ecn to\u00e0n di\u1ec7n h\u01a1n nhi\u1ec1u so v\u1edbi vi\u1ec7c ch\u1ec9 b\u00e0n lu\u1eadn v\u1ec1 ph\u01b0\u01a1ng ph\u00e1p pha.<\/p>\n\n\n\n

Ch\u1ea5t b\u00e9o b\u00e3o h\u00f2a trong c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc l\u00e0m t\u0103ng th\u00eam g\u00e1nh n\u1eb7ng LDL<\/h3>\n\n\n\n

Ch\u1ea5t b\u00e9o b\u00e3o h\u00f2a th\u00eam v\u00e0o c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc – b\u01a1, kem b\u00e9o (heavy cream), s\u1eefa nguy\u00ean kem, d\u1ea7u d\u1eeba v\u00e0 d\u1ea7u MCT – t\u1ef1 b\u1ea3n th\u00e2n ch\u00fang l\u00e0m t\u0103ng cholesterol LDL qua m\u1ed9t c\u01a1 ch\u1ebf ho\u00e0n to\u00e0n \u0111\u1ed9c l\u1eadp: ch\u00fang l\u00e0m gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng c\u1ee7a th\u1ee5 th\u1ec3 LDL trong gan b\u1eb1ng c\u00e1ch l\u00e0m t\u0103ng l\u01b0\u1ee3ng cholesterol n\u1ed9i b\u00e0o s\u1eb5n c\u00f3, m\u1ed9t con \u0111\u01b0\u1eddng v\u1eadn h\u00e0nh c\u1ed9ng d\u1ed3n th\u00eam v\u00e0o, ch\u1ee9 kh\u00f4ng thay th\u1ebf, c\u01a1 ch\u1ebf \u1ee9c ch\u1ebf sau phi\u00ean m\u00e3 c\u1ee7a cafestol. Khi b\u1ea1n k\u1ebft h\u1ee3p c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc v\u1edbi ch\u1ea5t b\u00e9o b\u00e3o h\u00f2a b\u1ed5 sung, b\u1ea1n \u0111ang x\u1ebfp ch\u1ed3ng hai c\u01a1 ch\u1ebf l\u00e0m t\u0103ng LDL ri\u00eang bi\u1ec7t trong c\u00f9ng m\u1ed9t t\u00e1ch c\u00e0 ph\u00ea.<\/p>\n\n\n\n

C\u00e0 ph\u00ea Bulletproof l\u00e0 v\u00ed d\u1ee5 r\u00f5 r\u00e0ng nh\u1ea5t v\u1ec1 r\u1ee7i ro c\u1ed9ng d\u1ed3n n\u00e0y. C\u00e1ch pha \u0111i\u1ec3n h\u00ecnh k\u1ebft h\u1ee3p c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc – th\u01b0\u1eddng l\u00e0 pha b\u1eb1ng French press ho\u1eb7c \u1ea5m Moka – v\u1edbi m\u1ed9t l\u01b0\u1ee3ng l\u1edbn b\u01a1 v\u00e0 d\u1ea7u MCT, c\u00f9ng l\u00fac n\u1ea1p v\u00e0o c\u01a1 th\u1ec3 m\u1ed9t l\u01b0\u1ee3ng cafestol \u0111\u00e1ng k\u1ec3 v\u00e0 m\u1ed9t l\u01b0\u1ee3ng l\u1edbn ch\u1ea5t b\u00e9o b\u00e3o h\u00f2a. Ch\u01b0a c\u00f3 th\u1eed nghi\u1ec7m c\u00f3 \u0111\u1ed1i ch\u1ee9ng d\u00e0i h\u1ea1n n\u00e0o \u0111o l\u01b0\u1eddng t\u00e1c \u0111\u1ed9ng lipid k\u1ebft h\u1ee3p c\u1ee7a s\u1ef1 pha tr\u1ed9n c\u1ee5 th\u1ec3 n\u00e0y, v\u00ec v\u1eady t\u1ed5ng t\u00e1c \u0111\u1ed9ng l\u00ean LDL ch\u1ec9 c\u00f3 th\u1ec3 \u01b0\u1edbc t\u00ednh b\u1eb1ng c\u00e1ch c\u1ed9ng hai c\u01a1 ch\u1ebf \u0111\u1ed9c l\u1eadp l\u1ea1i v\u1edbi nhau. \u0110\u1ed1i v\u1edbi b\u1ea5t k\u1ef3 ai \u0111ang theo d\u00f5i ch\u1ec9 s\u1ed1 cholesterol c\u1ee7a m\u00ecnh, \u0111\u00f3 kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t kho\u1ea3ng tr\u1ed1ng b\u1eb1ng ch\u1ee9ng d\u1ec5 ch\u1ecbu \u0111\u1ec3 b\u1ecf qua.<\/p>\n\n\n\n

\u0110i\u1ec3m th\u1ef1c ti\u1ec5n r\u1ea5t \u0111\u01a1n gi\u1ea3n: n\u1ebfu cholesterol l\u00e0 m\u1ed1i quan t\u00e2m, nh\u1eefng th\u1ee9 b\u1ea1n cho th\u00eam v\u00e0o c\u1ed1c c\u0169ng quan tr\u1ecdng kh\u00f4ng k\u00e9m g\u00ec c\u00e1ch b\u1ea1n pha n\u00f3. M\u1ed9t t\u00e1ch c\u00e0 ph\u00ea l\u1ecdc gi\u1ea5y nh\u01b0ng cho th\u00eam hai th\u00eca b\u01a1 th\u00ec kh\u00f4ng th\u1ec3 coi l\u00e0 m\u1ed9t t\u00e1ch c\u00e0 ph\u00ea trung t\u00ednh v\u1edbi cholesterol.<\/p>\n\n\n\n

Kho\u1ea3ng c\u00e1ch gi\u1edbi t\u00ednh trong \u0111\u1ed9 nh\u1ea1y c\u1ea3m v\u1edbi Cafestol: Ph\u1ea3n \u1ee9ng LDL cao h\u01a1n \u1edf nam gi\u1edbi<\/h3>\n\n\n\n

Kh\u1ea3o s\u00e1t Troms\u00f8 \u0111\u00e3 ghi nh\u1eadn s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1edbi t\u00ednh nh\u1ea5t qu\u00e1n trong c\u00e1ch LDL ph\u1ea3n \u1ee9ng v\u1edbi c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc: nam gi\u1edbi u\u1ed1ng t\u1eeb ba \u0111\u1ebfn n\u0103m t\u00e1ch espresso m\u1ed7i ng\u00e0y c\u00f3 m\u1ee9c t\u0103ng cholesterol kho\u1ea3ng +0,16 mmol\/L, trong khi ph\u1ee5 n\u1eef v\u1edbi c\u00f9ng m\u1ee9c ti\u00eau th\u1ee5 ch\u1ec9 t\u0103ng kho\u1ea3ng +0,09 mmol\/L – nam gi\u1edbi ph\u1ea3n \u1ee9ng v\u1edbi bi\u00ean \u0111\u1ed9 g\u1ea7n nh\u01b0 g\u1ea5p \u0111\u00f4i. \u0110\u00e2y l\u00e0 m\u1ed9t t\u00edn hi\u1ec7u d\u1ecbch t\u1ec5 h\u1ecdc m\u00e0 h\u1ea7u h\u1ebft c\u00e1c khuy\u1ebfn ngh\u1ecb dinh d\u01b0\u1ee1ng \u0111\u1ea1i ch\u00fang \u0111\u1ec1u b\u1ecf s\u00f3t. C\u00e1c h\u01b0\u1edbng d\u1eabn ti\u00eau chu\u1ea9n th\u01b0\u1eddng g\u1ed9p chung t\u1ea5t c\u1ea3 ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh, b\u1ecf l\u1ee1 c\u01a1 h\u1ed9i c\u1ea3nh b\u00e1o r\u1eb1ng nam gi\u1edbi c\u00f3 th\u1ec3 \u0111ang n\u1eb1m trong nh\u00f3m nh\u1ea1y c\u1ea3m cao h\u01a1n.<\/p>\n\n\n\n

C\u00e1c h\u1ee3p ch\u1ea5t \u0111\u00e1ng ch\u00fa \u00fd kh\u00e1c trong c\u00e0 ph\u00ea bao g\u1ed3m trigonelline v\u00e0 melanoidin<\/u><\/b><\/a>, \u0111\u00f3ng g\u00f3p v\u00e0o h\u01b0\u01a1ng th\u01a1m, th\u1ec3 ch\u1ea5t v\u00e0 c\u00e1c t\u00e1c \u0111\u1ed9ng s\u1ee9c kh\u1ecfe.<\/p>\n\n\n\n

L\u00fd do t\u1ed3n t\u1ea1i kho\u1ea3ng c\u00e1ch n\u00e0y v\u1eabn l\u00e0 m\u1ed9t c\u00e2u h\u1ecfi nghi\u00ean c\u1ee9u m\u1edf. Gi\u1ea3 thuy\u1ebft h\u00e0ng \u0111\u1ea7u li\u00ean quan \u0111\u1ebfn s\u1ef1 \u0111i\u1ec1u h\u00f2a bi\u1ec3u hi\u1ec7n th\u1ee5 th\u1ec3 LDL \u1edf gan d\u01b0\u1edbi t\u00e1c \u0111\u1ed9ng c\u1ee7a estrogen – estrogen \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0 l\u00e0m t\u0103ng th\u1ee5 th\u1ec3 LDL \u1edf ph\u1ee5 n\u1eef, \u0111i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 gi\u00fap \u0111\u1ec7m b\u1edbt ph\u1ea7n n\u00e0o t\u00e1c \u0111\u1ed9ng \u1ee9c ch\u1ebf c\u1ee7a cafestol – nh\u01b0ng s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 dung t\u00edch t\u00e1ch ph\u1ee5c v\u1ee5 \u0111i\u1ec3n h\u00ecnh, th\u1ec3 t\u00edch th\u1ef1c t\u1ebf v\u00e0 t\u1ed1c \u0111\u1ed9 chuy\u1ec3n h\u00f3a c\u0169ng c\u00f3 th\u1ec3 g\u00f3p ph\u1ea7n. C\u01a1 ch\u1ebf sinh h\u1ecdc ch\u00ednh x\u00e1c v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c gi\u1ea3i quy\u1ebft d\u1ee9t \u0111i\u1ec3m.<\/p>\n\n\n\n

\u0110i\u1ec1u m\u00e0 d\u1eef li\u1ec7u Troms\u00f8 x\u00e1c l\u1eadp \u0111\u1ee7 r\u00f5 r\u00e0ng \u0111\u1ec3 h\u00e0nh \u0111\u1ed9ng l\u00e0 nam gi\u1edbi n\u00ean t\u1ef1 x\u1ebfp m\u00ecnh v\u00e0o nh\u00f3m nh\u1ea1y c\u1ea3m cao h\u01a1n khi s\u1eed d\u1ee5ng c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc. C\u00f9ng m\u1ed9t th\u00f3i quen u\u1ed1ng espresso ch\u1ec9 l\u00e0m d\u1ecbch chuy\u1ec3n nh\u1eb9 ch\u1ec9 s\u1ed1 cholesterol \u1edf m\u1ed9t ph\u1ee5 n\u1eef nh\u01b0ng c\u00f3 th\u1ec3 t\u1ea1o ra s\u1ef1 thay \u0111\u1ed5i c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng l\u1edbn h\u01a1n \u1edf m\u1ed9t ng\u01b0\u1eddi \u0111\u00e0n \u00f4ng – v\u00e0 s\u1ef1 b\u1ea5t \u0111\u1ed1i x\u1ee9ng \u0111\u00f3 x\u1ee9ng \u0111\u00e1ng l\u00e0 m\u1ed9t ph\u1ea7n trong c\u00e1ch nam gi\u1edbi t\u1ef1 \u0111\u00e1nh gi\u00e1 r\u1ee7i ro c\u00e0 ph\u00ea c\u1ee7a b\u1ea3n th\u00e2n.<\/p>\n\n\n\n

\n\n\n\n

Quy\u1ebft \u0111\u1ecbnh u\u1ed1ng c\u00e0 ph\u00ea th\u00f4ng minh: C\u00e1c b\u01b0\u1edbc th\u1ef1c t\u1ebf v\u00e0 theo d\u00f5i Cholesterol<\/h2>\n\n\n\n

M\u1ed9t chi\u1ebfn l\u01b0\u1ee3c th\u01b0\u1edfng th\u1ee9c c\u00e0 ph\u00ea x\u00e2y d\u1ef1ng tr\u00ean n\u1ec1n t\u1ea3ng sinh h\u1ecdc th\u1ef1c t\u1ebf kh\u00f4ng \u0111\u00f2i h\u1ecfi b\u1ea1n ph\u1ea3i t\u1eeb b\u1ecf c\u00e0 ph\u00ea hay thay \u0111\u1ed5i l\u1ed1i s\u1ed1ng m\u1ed9t c\u00e1ch c\u1ef1c \u0111oan. N\u00f3 \u0111\u00f2i h\u1ecfi b\u1ea1n gh\u00e9p n\u1ed1i ph\u01b0\u01a1ng ph\u00e1p pha v\u1edbi m\u1ee9c \u0111\u1ed9 r\u1ee7i ro cholesterol c\u1ee7a b\u1ea3n th\u00e2n, \u0111i\u1ec1u ch\u1ec9nh c\u00e1c bi\u1ebfn s\u1ed1 trong t\u1ea7m ki\u1ec3m so\u00e1t, v\u00e0 \u0111\u1ec3 ch\u00ednh c\u00e1c ch\u1ec9 s\u1ed1 lipid m\u00e1u c\u1ee7a b\u1ea1n l\u00e0m th\u01b0\u1edbc \u0111o quy\u1ebft \u0111\u1ecbnh cu\u1ed1i c\u00f9ng.<\/p>\n\n\n\n

Khuy\u1ebfn ngh\u1ecb n\u1ec1n t\u1ea3ng r\u1ea5t tr\u1ef1c di\u1ec7n: h\u00e3y bi\u1ebfn c\u00e0 ph\u00ea l\u1ecdc gi\u1ea5y (m\u00e1y nh\u1ecf gi\u1ecdt ho\u1eb7c pour-over) th\u00e0nh l\u1ef1a ch\u1ecdn c\u00e0 ph\u00ea h\u00e0ng ng\u00e0y ch\u00ednh c\u1ee7a b\u1ea1n. M\u1ed9t m\u00e0ng l\u1ecdc gi\u1ea5y ti\u00eau chu\u1ea9n lo\u1ea1i b\u1ecf kho\u1ea3ng 98% cafestol v\u00e0 kahweol, khi\u1ebfn m\u1ed1i lo v\u1ec1 cholesterol g\u1ea7n nh\u01b0 b\u1ecb tri\u1ec7t ti\u00eau ho\u00e0n to\u00e0n b\u1ea5t k\u1ec3 b\u1ea1n u\u1ed1ng bao nhi\u00eau t\u00e1ch m\u1ed7i ng\u00e0y. Thay \u0111\u1ed5i \u0111\u01a1n l\u1ebb n\u00e0y l\u00e0 bi\u1ec7n ph\u00e1p can thi\u1ec7p mang l\u1ea1i hi\u1ec7u qu\u1ea3 \u0111\u00f2n b\u1ea9y cao nh\u1ea5t.<\/p>\n\n\n\n

N\u1ebfu b\u1ea1n th\u1ef1c s\u1ef1 y\u00eau th\u00edch French press, espresso hay c\u00e0 ph\u00ea \u0111un s\u00f4i v\u00e0 kh\u00f4ng mu\u1ed1n t\u1eeb b\u1ecf ch\u00fang ho\u00e0n to\u00e0n, b\u1ea3n ch\u1ea5t ph\u1ee5 thu\u1ed9c li\u1ec1u l\u01b0\u1ee3ng c\u1ee7a hi\u1ec7u \u1ee9ng n\u00e0y m\u1edf ra m\u1ed9t gi\u1ea3i ph\u00e1p dung h\u00f2a kh\u1ea3 thi. Gi\u1edbi h\u1ea1n m\u1ee9c ti\u00eau th\u1ee5 \u1edf m\u1ee9c m\u1ed9t \u0111\u1ebfn hai t\u00e1ch nh\u1ecf m\u1ed7i ng\u00e0y thay v\u00ec u\u1ed1ng t\u1ef1 \u0111\u1ed9ng theo th\u00f3i quen s\u1ebd gi\u1eef m\u1ee9c ph\u01a1i nhi\u1ec5m diterpene t\u00edch l\u0169y trong ph\u1ea1m vi m\u00e0 t\u00e1c \u0111\u1ed9ng l\u00ean LDL, \u0111\u1ed1i v\u1edbi h\u1ea7u h\u1ebft m\u1ecdi ng\u01b0\u1eddi, v\u1eabn \u1edf m\u1ee9c v\u1eeba ph\u1ea3i. T\u1eeb kh\u00f3a then ch\u1ed1t l\u00e0 c\u00f3 ch\u1ee7 \u0111\u00edch: h\u00e3y u\u1ed1ng c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc nh\u01b0 m\u1ed9t l\u1ef1a ch\u1ecdn th\u01b0\u1edfng th\u1ee9c c\u00f3 t\u00ednh to\u00e1n, ch\u1ee9 kh\u00f4ng ph\u1ea3i m\u1ed9t ph\u1ea3n x\u1ea1 m\u1eb7c \u0111\u1ecbnh.<\/p>\n\n\n\n

B\u1ea5t k\u1ec3 ph\u01b0\u01a1ng ph\u00e1p pha n\u00e0o, vi\u1ec7c lo\u1ea1i b\u1ecf c\u00e1c th\u00e0nh ph\u1ea7n b\u1ed5 sung gi\u00e0u ch\u1ea5t b\u00e9o b\u00e3o h\u00f2a – b\u01a1, kem b\u00e9o, d\u1ea7u d\u1eeba, d\u1ea7u MCT – s\u1ebd tri\u1ec7t ti\u00eau m\u1ed9t r\u1ee7i ro LDL c\u1ed9ng d\u1ed3n v\u1ed1n v\u1eadn h\u00e0nh \u0111\u1ed9c l\u1eadp v\u1edbi con \u0111\u01b0\u1eddng diterpene. N\u1ebfu ki\u1ec3m so\u00e1t cholesterol l\u00e0 \u01b0u ti\u00ean c\u1ee7a b\u1ea1n, \u0111i\u1ec1u n\u00e0y r\u1ea5t quan tr\u1ecdng.<\/p>\n\n\n\n

H\u00e0nh \u0111\u1ed9ng h\u1eefu \u00edch nh\u1ea5t \u0111\u1ec3 hi\u1ec3u r\u00f5 \u0111\u1ed9 nh\u1ea1y c\u1ea3m c\u00e1 nh\u00e2n l\u00e0 h\u00e3y \u0111i x\u00e9t nghi\u1ec7m b\u1ed9 m\u1ee1 m\u00e1u (lipid panel) l\u00fac \u0111\u00f3i ngay b\u00e2y gi\u1edd, thay \u0111\u1ed5i th\u00f3i quen u\u1ed1ng c\u00e0 ph\u00ea trong v\u00f2ng s\u00e1u \u0111\u1ebfn t\u00e1m tu\u1ea7n, v\u00e0 sau \u0111\u00f3 x\u00e9t nghi\u1ec7m l\u1ea1i. Ph\u1ea3n \u1ee9ng c\u1ee7a t\u1eebng c\u00e1 nh\u00e2n \u0111\u1ed1i v\u1edbi cafestol r\u1ea5t kh\u00e1c nhau – m\u1ed9t s\u1ed1 ng\u01b0\u1eddi c\u00f3 m\u1ee9c d\u1ecbch chuy\u1ec3n LDL l\u1edbn, s\u1ed1 kh\u00e1c l\u1ea1i thay \u0111\u1ed5i t\u1ed1i thi\u1ec3u – v\u00e0 d\u1eef li\u1ec7u c\u1ee7a ch\u00ednh b\u1ea1n lu\u00f4n mang t\u00ednh ch\u1ec9 d\u1eabn cao h\u01a1n b\u1ea5t k\u1ef3 m\u1ee9c trung b\u00ecnh d\u00e2n s\u1ed1 n\u00e0o. \u0110i\u1ec1u n\u00e0y \u0111\u1eb7c bi\u1ec7t ph\u00f9 h\u1ee3p v\u1edbi nam gi\u1edbi, nh\u1eefng ng\u01b0\u1eddi m\u00e0 d\u1eef li\u1ec7u kh\u1ea3o s\u00e1t Troms\u00f8 g\u1ee3i \u00fd r\u1eb1ng c\u00f3 th\u1ec3 ph\u1ea3n \u1ee9ng m\u1ea1nh m\u1ebd h\u01a1n v\u1edbi c\u00f9ng m\u1ed9t m\u1ee9c ti\u00eau th\u1ee5 so v\u1edbi ph\u1ee5 n\u1eef.<\/p>\n\n\n\n

Cu\u1ed1i c\u00f9ng, h\u00e3y gi\u1eef c\u00e1i nh\u00ecn t\u1ed5ng th\u1ec3 m\u1ed9t c\u00e1ch ch\u1eebng m\u1ef1c. M\u1ee9c t\u0103ng LDL t\u1eeb c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc v\u1eeba ph\u1ea3i l\u00e0 c\u00f3 th\u1eadt v\u00e0 c\u1ea7n \u0111\u01b0\u1ee3c l\u01b0u t\u00e2m, nh\u01b0ng n\u00f3 ch\u1ec9 l\u00e0 m\u1ed9t bi\u1ebfn s\u1ed1 trong m\u1ed9t h\u1ec7 th\u1ed1ng l\u1edbn bao g\u1ed3m ch\u1ebf \u0111\u1ed9 \u0103n, m\u1ee9c \u0111\u1ed9 ho\u1ea1t \u0111\u1ed9ng th\u1ec3 ch\u1ea5t, ti\u1ec1n s\u1eed gia \u0111\u00ecnh v\u00e0 nguy c\u01a1 tim m\u1ea1ch n\u1ec1n t\u1ea3ng c\u1ee7a b\u1ea1n. B\u1ea3n th\u00e2n c\u00e0 ph\u00ea – k\u1ec3 c\u1ea3 c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc – c\u0169ng mang l\u1ea1i nh\u1eefng l\u1ee3i \u00edch \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn, v\u00e0 m\u1ee5c ti\u00eau kh\u00f4ng ph\u1ea3i l\u00e0 ki\u00eang khem tuy\u1ec7t \u0111\u1ed1i. M\u1ee5c ti\u00eau l\u00e0 s\u1ef1 h\u00f2a h\u1ee3p: \u0111i\u1ec1u ch\u1ec9nh th\u00f3i quen c\u00e0 ph\u00ea ph\u00f9 h\u1ee3p v\u1edbi m\u1ee9c \u0111\u1ed9 ch\u1ea5p nh\u1eadn r\u1ee7i ro th\u1ef1c t\u1ebf c\u1ee7a b\u1ea1n, \u0111\u01b0\u1ee3c d\u1eabn l\u1ed1i b\u1edfi ch\u00ednh c\u00e1c con s\u1ed1 cholesterol c\u1ee7a b\u1ea3n th\u00e2n ch\u1ee9 kh\u00f4ng ph\u1ea3i ch\u1ec9 s\u1ed1 trung b\u00ecnh c\u1ee7a ai kh\u00e1c.<\/p>\n\n\n\n

D\u01b0\u1edbi \u0111\u00e2y l\u00e0 m\u1ed9t video s\u00fac t\u00edch ph\u00e2n t\u00edch ch\u00ednh x\u00e1c l\u00fd do t\u1ea1i sao l\u1ef1a ch\u1ecdn c\u00e1ch pha c\u00e0 ph\u00ea c\u00f3 th\u1ec3 l\u00e0m d\u1ecbch chuy\u1ec3n c\u00e1c ch\u1ec9 s\u1ed1 cholesterol c\u1ee7a b\u1ea1n – r\u1ea5t \u0111\u00e1ng xem tr\u01b0\u1edbc khi b\u1ea1n \u0111\u01b0a ra quy\u1ebft \u0111\u1ecbnh pha ch\u1ebf ti\u1ebfp theo.<\/p>\n\n\n\n

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