{"id":54031,"date":"2026-06-18T19:39:40","date_gmt":"2026-06-18T12:39:40","guid":{"rendered":"https:\/\/coffeefactz.com\/?p=54031"},"modified":"2026-09-04T19:08:51","modified_gmt":"2026-09-04T12:08:51","slug":"cac-nhom-hop-chat-hoat-tinh-sinh-hoc-trong-ca-phe","status":"publish","type":"post","link":"https:\/\/coffeefactz.com\/vi\/cac-nhom-hop-chat-hoat-tinh-sinh-hoc-trong-ca-phe\/","title":{"rendered":"C\u00e1c Nh\u00f3m H\u1ee3p Ch\u1ea5t Ho\u1ea1t T\u00ednh Sinh H\u1ecdc Trong C\u00e0 Ph\u00ea: B\u1ea3n Ch\u1ea5t H\u00f3a H\u1ecdc \u0110\u1eb1ng Sau M\u1ecdi L\u1ee3i \u00cdch S\u1ee9c Kh\u1ecfe"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">C\u00e1c nh\u00f3m h\u1ee3p ch\u1ea5t ho\u1ea1t t\u00ednh sinh h\u1ecdc trong c\u00e0 ph\u00ea t\u1ea1o n\u00ean m\u1ed9t trong nh\u1eefng ma tr\u1eadn h\u00f3a h\u1ecdc ph\u1ee9c t\u1ea1p nh\u1ea5t trong ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng c\u1ee7a con ng\u01b0\u1eddi \u2014 s\u1ef1 k\u1ebft h\u1ee3p nh\u1ecbp nh\u00e0ng gi\u1eefa alkaloid, polyphenol, diterpene v\u00e0 c\u00e1c polymer gi\u00e0u nit\u01a1 c\u00f9ng t\u00e1c \u0111\u1ed9ng l\u00ean nhi\u1ec1u h\u1ec7 c\u01a1 quan. Coi c\u00e0 ph\u00ea ch\u1ec9 l\u00e0 th\u1ee9c u\u1ed1ng n\u1ea1p caffeine ch\u1eb3ng kh\u00e1c n\u00e0o g\u1ecdi r\u01b0\u1ee3u vang \u0111\u1ecf l\u00e0 &#8220;n\u01b0\u1edbc \u0111\u01b0\u1eddng l\u00ean men&#8221;: \u0111\u00fang v\u1ec1 m\u1eb7t c\u00e2u ch\u1eef, nh\u01b0ng ho\u00e0n to\u00e0n sai l\u1ec7ch v\u1ec1 b\u1ea3n ch\u1ea5t sinh h\u1ecdc.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e2u chuy\u1ec7n s\u1ee9c kh\u1ecfe trong t\u00e1ch c\u00e0 ph\u00ea \u0111\u01b0\u1ee3c vi\u1ebft n\u00ean b\u1edfi axit chlorogenic, melanoidin, trigonelline, cafestol v\u00e0 kahweol c\u00f9ng ph\u1ed1i h\u1ee3p nh\u1ecbp nh\u00e0ng \u2014 ch\u1ee9 kh\u00f4ng ph\u1ea3i m\u1ed9t ph\u00e2n t\u1eed \u0111\u01a1n \u0111\u1ed9c n\u00e0o. Qu\u00e1 tr\u00ecnh rang bi\u1ebfn \u0111\u1ed5i ch\u00fang ra sao, v\u00e0 ph\u01b0\u01a1ng ph\u00e1p pha ch\u1ebf gi\u1eef l\u1ea1i hay lo\u1ea1i b\u1ecf nh\u1eefng g\u00ec, s\u1ebd quy\u1ebft \u0111\u1ecbnh ch\u00ednh x\u00e1c d\u1ea1ng ho\u1ea1t ch\u1ea5t n\u00e0o th\u1ef1c s\u1ef1 \u0111i v\u00e0o t\u1ebf b\u00e0o c\u1ee7a b\u1ea1n.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">C\u00e0 Ph\u00ea: M\u1ed9t B\u1ea3n Giao H\u01b0\u1edfng H\u00f3a H\u1ecdc, Kh\u00f4ng Ch\u1ec9 C\u00f3 Caffeine<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Ma tr\u1eadn ho\u1ea1t t\u00ednh sinh h\u1ecdc c\u1ee7a c\u00e0 ph\u00ea rang ch\u1ee9a h\u01a1n 1.000 h\u1ee3p ch\u1ea5t \u0111\u00e3 \u0111\u01b0\u1ee3c nh\u1eadn di\u1ec7n \u2014 m\u1eadt \u0111\u1ed9 h\u00f3a h\u1ecdc d\u00e0y \u0111\u1eb7c n\u00e0y \u0111\u01b0a n\u00f3 g\u1ea7n v\u1edbi m\u1ed9t lo\u1ea1i th\u1ef1c ph\u1ea9m to\u00e0n ph\u1ea7n h\u01a1n l\u00e0 th\u1ef1c ph\u1ea9m b\u1ed5 sung nh\u00e2n t\u1ea1o. \u0110i\u1ec1u n\u00e0y khi\u1ebfn quan ni\u1ec7m ph\u1ed5 bi\u1ebfn &#8220;c\u00e0 ph\u00ea th\u1ef1c ra ch\u1ec9 l\u00e0 caffeine&#8221; ho\u00e0n to\u00e0n s\u1ee5p \u0111\u1ed5. Nh\u1eefng l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe t\u1eeb th\u00f3i quen u\u1ed1ng c\u00e0 ph\u00ea \u0111\u1ec1u \u0111\u1eb7n kh\u00f4ng b\u1eaft ngu\u1ed3n t\u1eeb m\u1ed9t alkaloid duy nh\u1ea5t; ch\u00fang n\u1ea3y sinh t\u1eeb s\u1ef1 t\u01b0\u01a1ng t\u00e1c \u0111a t\u1ea7ng gi\u1eefa polyphenol, diterpene, alkaloid v\u00e0 melanoidin, m\u1ed7i nh\u00f3m l\u1ea1i nh\u1eafm v\u00e0o nh\u1eefng \u0111\u00edch sinh h\u1ecdc kh\u00e1c nhau trong chu\u1ed7i ti\u00eau h\u00f3a v\u00e0 chuy\u1ec3n h\u00f3a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">H\u00e3y th\u1eed ngh\u0129 theo c\u00e1ch n\u00e0y: n\u1ebfu caffeine l\u00e0 ho\u1ea1t ch\u1ea5t duy nh\u1ea5t c\u00f3 t\u00e1c d\u1ee5ng, th\u00ec c\u00e0 ph\u00ea kh\u1eed caffeine (decaf) h\u1eb3n s\u1ebd kh\u00f4ng mang l\u1ea1i l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe n\u00e0o. Nh\u01b0ng th\u1ef1c t\u1ebf ho\u00e0n to\u00e0n ng\u01b0\u1ee3c l\u1ea1i. D\u1eef li\u1ec7u d\u1ecbch t\u1ec5 h\u1ecdc li\u00ean t\u1ee5c ch\u1ec9 ra m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa vi\u1ec7c u\u1ed1ng c\u00e0 ph\u00ea decaf v\u1edbi s\u1ef1 suy gi\u1ea3m nguy c\u01a1 m\u1eafc ti\u1ec3u \u0111\u01b0\u1eddng type 2 v\u00e0 b\u1ec7nh gan \u2014 nh\u1eefng k\u1ebft qu\u1ea3 n\u00e0y g\u1eafn li\u1ec1n v\u1edbi h\u00e0m l\u01b0\u1ee3ng axit chlorogenic v\u00e0 melanoidin, ch\u1ee9 kh\u00f4ng h\u1ec1 ph\u1ee5 thu\u1ed9c v\u00e0o caffeine. Ch\u1ec9 ri\u00eang ph\u00e1t hi\u1ec7n \u0111\u00f3 \u0111\u00e3 \u0111\u1ee7 \u0111\u1ec3 ch\u00fang ta ph\u1ea3i \u0111\u1ecbnh h\u00ecnh l\u1ea1i c\u00e1ch nh\u00ecn nh\u1eadn v\u1ec1 th\u1ee9c u\u1ed1ng quen thu\u1ed9c n\u00e0y.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">S\u1ef1 t\u01b0\u01a1ng \u0111\u1ed3ng v\u1edbi th\u1ef1c ph\u1ea9m to\u00e0n ph\u1ea7n l\u00e0 m\u1ed9t \u0111i\u1ec3m r\u1ea5t \u0111\u00e1ng l\u01b0u t\u00e2m. Khi \u0103n m\u1ed9t qu\u1ea3 vi\u1ec7t qu\u1ea5t, b\u1ea1n kh\u00f4ng h\u1ec1 n\u1ea1p resveratrol \u0111\u01a1n l\u1ebb \u2014 b\u1ea1n \u0111ang n\u1ea1p m\u1ed9t m\u1ea1ng l\u01b0\u1edbi ho\u00e0n ch\u1ec9nh g\u1ed3m polyphenol, ch\u1ea5t x\u01a1 v\u00e0 vi ch\u1ea5t dinh d\u01b0\u1ee1ng, m\u00e0 hi\u1ec7u qu\u1ea3 t\u1ed5ng h\u00f2a c\u1ee7a ch\u00fang kh\u00e1c bi\u1ec7t ho\u00e0n to\u00e0n so v\u1edbi b\u1ea5t k\u1ef3 chi\u1ebft xu\u1ea5t \u0111\u01a1n l\u1ebb n\u00e0o. C\u00e0 ph\u00ea c\u0169ng v\u1eadn h\u00e0nh y h\u1ec7t nh\u01b0 v\u1eady. S\u1ef1 t\u01b0\u01a1ng t\u00e1c t\u01b0\u01a1ng h\u1ed7 gi\u1eefa c\u00e1c th\u00e0nh ph\u1ea7n \u2014 \u0111i\u1ec1u m\u00e0 c\u00e1c nh\u00e0 h\u00f3a sinh dinh d\u01b0\u1ee1ng g\u1ecdi l\u00e0 &#8220;hi\u1ec7u \u1ee9ng ma tr\u1eadn&#8221; (matrix effect) \u2014 t\u1ea1o n\u00ean k\u1ebft qu\u1ea3 sinh h\u1ecdc to\u00e0n di\u1ec7n m\u00e0 kh\u00f4ng vi\u00ean u\u1ed1ng b\u1ed5 sung \u0111\u01a1n ch\u1ea5t n\u00e0o c\u00f3 th\u1ec3 sao ch\u00e9p \u0111\u01b0\u1ee3c.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00f2n m\u1ed9t m\u1ea5u ch\u1ed1t quan tr\u1ecdng n\u1eefa c\u1ea7n ghi nh\u1edb: kh\u00f4ng ph\u1ea3i t\u1ea5t c\u1ea3 c\u00e1c h\u1ee3p ch\u1ea5t n\u00e0y \u0111\u1ec1u gi\u1eef nguy\u00ean v\u1eb9n t\u1eeb h\u1ea1t nh\u00e2n xanh cho t\u1edbi ly c\u00e0 ph\u00ea th\u00e0nh ph\u1ea9m. Qu\u00e1 tr\u00ecnh rang nhi\u1ec7t s\u1ebd ph\u00e2n h\u1ee7y m\u1ed9t s\u1ed1 ch\u1ea5t, \u0111\u1ed3ng th\u1eddi khai sinh ra nh\u1eefng h\u1ee3p ch\u1ea5t ho\u00e0n to\u00e0n m\u1edbi, v\u00e0 c\u00e1ch pha ch\u1ebf s\u1ebd quy\u1ebft \u0111\u1ecbnh ch\u1ea5t n\u00e0o \u0111\u01b0\u1ee3c chi\u1ebft xu\u1ea5t v\u00e0o t\u00e1ch n\u01b0\u1edbc b\u1ea1n u\u1ed1ng. N\u1eafm r\u00f5 b\u1ea3n ch\u1ea5t h\u00f3a h\u1ecdc n\u00e0y s\u1ebd gi\u00fap b\u1ea1n \u0111\u01b0a ra l\u1ef1a ch\u1ecdn s\u00e1ng su\u1ed1t tr\u01b0\u1edbc khi quy\u1ebft \u0111\u1ecbnh ch\u1ecdn lo\u1ea1i rang \u0111\u1eadm hay nh\u1ea1t tr\u00ean k\u1ec7.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1280\" height=\"720\" src=\"https:\/\/coffeefactz.com\/wp-content\/uploads\/2026\/06\/macro-roasted-coffee-bean-compounds.webp\" alt=\"Macro view of roasted coffee beans showing oil texture and bioactive compounds.\" class=\"wp-image-51150\" title=\"\" srcset=\"https:\/\/coffeefactz.com\/wp-content\/uploads\/2026\/06\/macro-roasted-coffee-bean-compounds.webp 1280w, https:\/\/coffeefactz.com\/wp-content\/uploads\/2026\/06\/macro-roasted-coffee-bean-compounds-300x169.webp 300w, https:\/\/coffeefactz.com\/wp-content\/uploads\/2026\/06\/macro-roasted-coffee-bean-compounds-1024x576.webp 1024w, https:\/\/coffeefactz.com\/wp-content\/uploads\/2026\/06\/macro-roasted-coffee-bean-compounds-768x432.webp 768w\" sizes=\"(max-width: 1280px) 100vw, 1280px\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.frontiersin.org\/journals\/nutrition\" rel=\"nofollow noopener\" target=\"_blank\"><u><strong>GS. Elvira Gonzalez de Mejia<\/strong><\/u><\/a>, Gi\u00e1o s\u01b0 Khoa h\u1ecdc Th\u1ef1c ph\u1ea9m v\u00e0 Dinh d\u01b0\u1ee1ng Con ng\u01b0\u1eddi t\u1ea1i \u0110\u1ea1i h\u1ecdc Illinois Urbana-Champaign, nh\u1eadn \u0111\u1ecbnh r\u1ea5t r\u00f5 r\u00e0ng: c\u00e0 ph\u00ea kh\u00f4ng \u0111\u01a1n thu\u1ea7n l\u00e0 c\u00f4ng c\u1ee5 n\u1ea1p caffeine m\u00e0 l\u00e0 m\u1ed9t h\u1ec7 th\u1ed1ng sinh h\u1ecdc hi\u1ec7p \u0111\u1ed3ng (biosynergistic system) \u2014 n\u01a1i c\u00e1c polyphenol nh\u01b0 axit chlorogenic, alkaloid nh\u01b0 trigonelline, diterpene nh\u01b0 cafestol, c\u00f9ng c\u00e1c kho\u00e1ng ch\u1ea5t vi l\u01b0\u1ee3ng g\u1ed3m magie v\u00e0 kali c\u00f9ng t\u1ea1o n\u00ean m\u1ed9t h\u1ed3 s\u01a1 sinh l\u00fd m\u00e0 kh\u00f4ng m\u1ed9t h\u1ee3p ch\u1ea5t ri\u00eang l\u1ebb n\u00e0o c\u00f3 th\u1ec3 g\u00e1nh v\u00e1c n\u1ed5i. Tr\u00ean th\u1ef1c t\u1ebf, c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe c\u1ee7a c\u00e0 ph\u00ea ch\u1ec9 th\u1ef1c s\u1ef1 c\u00f3 \u00fd ngh\u0129a khi \u0111\u01b0\u1ee3c xem x\u00e9t d\u01b0\u1edbi l\u0103ng k\u00ednh c\u1ee7a to\u00e0n b\u1ed9 h\u1ed7n h\u1ee3p t\u1ef1 nhi\u00ean, thay v\u00ec ch\u1ec9 ch\u0103m ch\u00fa v\u00e0o d\u01b0\u1ee3c l\u00fd h\u1ecdc h\u1ea1n h\u1eb9p c\u1ee7a caffeine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Nh\u1eefng G\u01b0\u01a1ng M\u1eb7t Ho\u1ea1t T\u00ednh Sinh H\u1ecdc Ch\u1ee7 Ch\u1ed1t Trong T\u00e1ch C\u00e0 Ph\u00ea<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c nh\u00f3m h\u1ee3p ch\u1ea5t ho\u1ea1t t\u00ednh sinh h\u1ecdc trong c\u00e0 ph\u00ea tr\u1ea3i r\u1ed9ng qua nhi\u1ec1u h\u1ecd h\u00f3a h\u1ecdc, m\u1ed7i h\u1ecd mang m\u1ed9t c\u1ea5u tr\u00fac ph\u00e2n t\u1eed ri\u00eang bi\u1ec7t v\u00e0 nh\u1eafm \u0111\u1ebfn c\u00e1c \u0111\u00edch sinh h\u1ecdc kh\u00e1c nhau \u2014 n\u1eafm r\u00f5 vai tr\u00f2 c\u1ee7a t\u1eebng ch\u1ea5t l\u00e0 ti\u1ec1n \u0111\u1ec1 \u0111\u1ec3 hi\u1ec3u \u0111\u00fang m\u1ecdi nh\u1eadn \u0111\u1ecbnh s\u1ee9c kh\u1ecfe. M\u1ed9t t\u00e1ch c\u00e0 ph\u00ea l\u1ecdc gi\u1ea5y ti\u00eau chu\u1ea9n 240ml (8 oz) c\u00f3 th\u1ec3 mang l\u1ea1i 50\u2013200 mg axit chlorogenic, 80\u2013120 mg caffeine, c\u00f9ng m\u1ed9t l\u01b0\u1ee3ng \u0111\u00e1ng k\u1ec3 trigonelline, melanoidin v\u00e0 diterpene t\u00f9y thu\u1ed9c v\u00e0o \u0111\u1ed9 rang v\u00e0 c\u00e1ch pha ch\u1ebf. \u0110\u00e2y kh\u00f4ng ph\u1ea3i l\u00e0 l\u01b0\u1ee3ng t\u1ea1p ch\u1ea5t v\u1ebft \u2014 m\u00e0 l\u00e0 nh\u1eefng li\u1ec1u l\u01b0\u1ee3ng c\u00f3 \u00fd ngh\u0129a d\u01b0\u1ee3c l\u00fd r\u00f5 r\u1ec7t t\u1eeb c\u00e1c h\u1ee3p ch\u1ea5t \u0111a d\u1ea1ng c\u00f9ng l\u00fac t\u00e1c \u0111\u1ed9ng l\u00ean c\u01a1 th\u1ec3.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">D\u01b0\u1edbi \u0111\u00e2y l\u00e0 c\u00e1c th\u00e0nh ph\u1ea7n ch\u1ee7 ch\u1ed1t:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Caffeine<\/strong> \u2014 alkaloid \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u k\u1ef9 l\u01b0\u1ee1ng nh\u1ea5t trong ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng c\u1ee7a con ng\u01b0\u1eddi. N\u00f3 d\u1ec5 d\u00e0ng v\u01b0\u1ee3t qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o, phong t\u1ecfa c\u00e1c th\u1ee5 th\u1ec3 adenosine v\u00e0 mang l\u1ea1i c\u1ea3m gi\u00e1c t\u1ec9nh t\u00e1o quen thu\u1ed9c. Tuy nhi\u00ean, vai tr\u00f2 c\u1ee7a caffeine kh\u00f4ng ch\u1ec9 d\u1eebng l\u1ea1i \u1edf s\u1ef1 t\u1ec9nh t\u00e1o: c\u00e1c nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec5 h\u1ecdc li\u00ean t\u1ee5c ch\u1ec9 ra t\u00edn hi\u1ec7u b\u1ea3o v\u1ec7 th\u1ea7n kinh c\u1ee7a caffeine, \u0111\u1eb7c bi\u1ec7t l\u00e0 gi\u1ea3m nguy c\u01a1 m\u1eafc b\u1ec7nh Parkinson v\u00e0 Alzheimer.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Axit chlorogenic (CGA)<\/strong> \u2014 h\u1ecd polyphenol chi\u1ebfm \u01b0u th\u1ebf tuy\u1ec7t \u0111\u1ed1i trong c\u00e0 ph\u00ea, v\u1edbi n\u1ed3ng \u0111\u1ed9 bi\u1ebfn c\u00e0 ph\u00ea tr\u1edf th\u00e0nh ngu\u1ed3n cung c\u1ea5p polyphenol h\u00e0ng \u0111\u1ea7u trong ch\u1ebf \u0111\u1ed9 \u0103n c\u1ee7a ng\u01b0\u1eddi ph\u01b0\u01a1ng T\u00e2y. CGA l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a m\u1ea1nh m\u1ebd, nh\u01b0ng vai tr\u00f2 \u1ea5n t\u01b0\u1ee3ng h\u01a1n l\u1ea1i n\u1eb1m \u1edf chuy\u1ec3n h\u00f3a: ch\u00fang \u0111i\u1ec1u h\u00f2a h\u1ea5p thu glucose t\u1ea1i ru\u1ed9t gi\u00e0, t\u00e1c \u0111\u1ed9ng t\u00edch c\u1ef1c \u0111\u1ebfn t\u00edn hi\u1ec7u insulin v\u00e0 k\u00edch ho\u1ea1t c\u00e1c con \u0111\u01b0\u1eddng ph\u00f2ng th\u1ee7 t\u1ebf b\u00e0o t\u1ea1i gan. \u0110\u00e2y c\u0169ng l\u00e0 h\u1ee3p ch\u1ea5t nh\u1ea1y c\u1ea3m v\u1edbi nhi\u1ec7t \u0111\u1ed9 rang nh\u1ea5t trong h\u1ea1t c\u00e0 ph\u00ea.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Trigonelline<\/strong> \u2014 m\u1ed9t alkaloid b\u1ecb bi\u1ebfn \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 khi g\u1eb7p nhi\u1ec7t \u0111\u1ed9 rang. D\u01b0\u1edbi t\u00e1c \u0111\u1ed9ng nhi\u1ec7t, m\u1ed9t ph\u1ea7n trigonelline chuy\u1ec3n h\u00f3a th\u00e0nh axit nicotinic (niacin, vitamin B3), bi\u1ebfn c\u00e0 ph\u00ea rang \u0111\u1eadm th\u00e0nh ngu\u1ed3n cung c\u1ea5p khi\u00eam t\u1ed1n nh\u01b0ng h\u1eefu \u00edch c\u1ee7a m\u1ed9t lo\u1ea1i vitamin m\u00e0 nhi\u1ec1u ng\u01b0\u1eddi th\u01b0\u1eddng ngh\u0129 ch\u1ec9 c\u00f3 trong th\u1ecbt v\u00e0 \u0111\u1eadu. \u1ede d\u1ea1ng nguy\u00ean v\u1eb9n, trigonelline c\u0169ng th\u1ec3 hi\u1ec7n ho\u1ea1t t\u00ednh b\u1ea3o v\u1ec7 th\u1ea7n kinh v\u00e0 h\u1ed7 tr\u1ee3 \u0111i\u1ec1u h\u00f2a \u0111\u01b0\u1eddng huy\u1ebft trong c\u00e1c m\u00f4 h\u00ecnh th\u1ef1c nghi\u1ec7m.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Melanoidin<\/strong> \u2014 c\u00e1c polymer tr\u1ecdng l\u01b0\u1ee3ng ph\u00e2n t\u1eed cao m\u00e0u n\u00e2u ch\u1ecbu tr\u00e1ch nhi\u1ec7m t\u1ea1o n\u00ean m\u00e0u s\u1eafc v\u00e0 m\u1ed9t ph\u1ea7n v\u1ecb \u0111\u1eafng \u0111\u1eb7c tr\u01b0ng c\u1ee7a c\u00e0 ph\u00ea. Ch\u00fang h\u00ecnh th\u00e0nh trong qu\u00e1 tr\u00ecnh rang th\u00f4ng qua ph\u1ea3n \u1ee9ng Maillard gi\u1eefa \u0111\u01b0\u1eddng kh\u1eed v\u00e0 axit amin, \u0111\u1ed3ng th\u1eddi c\u00f3 h\u00e0nh vi gi\u1ed1ng nh\u01b0 ch\u1ea5t x\u01a1 h\u00f2a tan h\u01a1n l\u00e0 m\u1ed9t ho\u1ea1t ch\u1ea5t sinh h\u1ecdc th\u00f4ng th\u01b0\u1eddng. <a href=\"https:\/\/www.frontiersin.org\/journals\/nutrition\" rel=\"nofollow noopener\" target=\"_blank\"><u><strong>TS. Maria Dolores del Castillo<\/strong><\/u><\/a>, Tr\u01b0\u1edfng nh\u00f3m Sinh h\u1ecdc Th\u1ef1c ph\u1ea9m t\u1ea1i Vi\u1ec7n Nghi\u00ean c\u1ee9u Khoa h\u1ecdc Th\u1ef1c ph\u1ea9m T\u00e2y Ban Nha, l\u01b0u \u00fd r\u1eb1ng melanoidin trong c\u00e0 ph\u00ea c\u00f3 ho\u1ea1t t\u00ednh ch\u1ed1ng oxy h\u00f3a m\u1ea1nh h\u01a1n h\u1eb3n melanoidin t\u1eeb c\u00e1c th\u1ef1c ph\u1ea9m n\u01b0\u1edbng nhi\u1ec7t kh\u00e1c \u2014 v\u00e0 v\u00ec kh\u00f4ng b\u1ecb ti\u00eau h\u00f3a \u1edf ru\u1ed9t non, ch\u00fang di chuy\u1ec3n nguy\u00ean v\u1eb9n \u0111\u1ebfn \u0111\u1ea1i tr\u00e0ng, n\u01a1i vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t ph\u00e2n gi\u1ea3i v\u00e0 gi\u1ea3i ph\u00f3ng c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u1ed1ng oxy h\u00f3a t\u00edch c\u1ef1c. \u0110i\u1ec1u n\u00e0y bi\u1ebfn melanoidin th\u00e0nh ho\u1ea1t ch\u1ea5t h\u01b0\u1edbng ru\u1ed9t v\u1edbi l\u1ed9 tr\u00ecnh t\u00e1c \u0111\u1ed9ng ho\u00e0n to\u00e0n kh\u00e1c bi\u1ec7t so v\u1edbi c\u00e1c ch\u1ea5t h\u1ea5p thu s\u1edbm.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Cafestol v\u00e0 kahweol<\/strong> \u2014 c\u1eb7p \u0111\u00f4i diterpene t\u1ea1o n\u00ean s\u1ef1 kh\u00e1c bi\u1ec7t c\u1ed1t l\u00f5i gi\u1eefa c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc v\u00e0 c\u00e0 ph\u00ea l\u1ecdc qua gi\u1ea5y. C\u1ea3 hai \u0111\u1ec1u cho th\u1ea5y t\u00edn hi\u1ec7u ch\u1ed1ng ung th\u01b0 trong c\u00e1c th\u1eed nghi\u1ec7m ti\u1ec1n l\u00e2m s\u00e0ng, nh\u01b0ng l\u1ea1i l\u00e0m t\u0103ng cholesterol x\u1ea5u LDL trong huy\u1ebft thanh ng\u01b0\u1eddi \u2014 m\u1ed9t ranh gi\u1edbi \u0111\u00e1nh \u0111\u1ed5i tim m\u1ea1ch th\u1ef1c t\u1ebf m\u00e0 gi\u1edbi truy\u1ec1n th\u00f4ng s\u1ee9c kh\u1ecfe th\u01b0\u1eddng hay b\u1ecf qu\u00ean. Ch\u00fang ta s\u1ebd \u0111\u00e0o s\u00e2u h\u01a1n khi b\u00e0n v\u1ec1 ph\u01b0\u01a1ng ph\u00e1p pha ch\u1ebf.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Kh\u00f4ng m\u1ed9t h\u1ee3p ch\u1ea5t n\u00e0o ho\u1ea1t \u0111\u1ed9ng \u0111\u01a1n \u0111\u1ed9c. T\u00e1c \u0111\u1ed9ng c\u1ed9ng h\u01b0\u1edfng \u2014 hi\u1ec7p \u0111\u1ed3ng \u1edf m\u1ed9t s\u1ed1 m\u1eb7t, \u0111\u00f4i khi l\u1ea1i \u0111\u1ed1i kh\u00e1ng \u1edf m\u1eb7t kh\u00e1c \u2014 m\u1edbi l\u00e0 th\u1ee9 \u0111\u1ecbnh h\u00ecnh k\u1ebft qu\u1ea3 s\u1ee9c kh\u1ecfe sau c\u00f9ng. Hi\u1ec3u r\u00f5 t\u1eebng h\u1ee3p ch\u1ea5t ri\u00eang l\u1ebb l\u00e0 n\u1ec1n m\u00f3ng, nh\u01b0ng kh\u00e1m ph\u00e1 s\u1ef1 t\u01b0\u01a1ng t\u00e1c gi\u1eefa ch\u00fang m\u1edbi l\u00e0 n\u01a1i sinh h\u1ecdc tr\u1edf n\u00ean h\u1ea5p d\u1eabn.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">L\u1ee3i \u00cdch S\u1ee9c Kh\u1ecfe: B\u1eb1ng Ch\u1ee9ng Nghi\u00ean C\u1ee9u Th\u1ef1c T\u1ebf N\u00f3i L\u00ean \u0110i\u1ec1u G\u00ec?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kh\u1ea3 n\u0103ng gi\u1ea3m nguy c\u01a1 m\u1eafc b\u1ec7nh c\u1ee7a c\u00e0 ph\u00ea l\u00e0 m\u1ed9t trong nh\u1eefng ph\u00e1t hi\u1ec7n nh\u1ea5t qu\u00e1n v\u00e0 v\u1eefng ch\u1eafc nh\u1ea5t trong d\u1ecbch t\u1ec5 h\u1ecdc dinh d\u01b0\u1ee1ng \u2014 kh\u00f4ng ph\u1ea3i l\u00e0 s\u1ef1 t\u01b0\u01a1ng quan m\u01a1 h\u1ed3, m\u00e0 l\u00e0 m\u1ed9t quy lu\u1eadt l\u1eb7p l\u1ea1i qua h\u00e0ng ch\u1ee5c nghi\u00ean c\u1ee9u thu\u1ea7n t\u1eadp quy m\u00f4 l\u1edbn v\u00e0 nhi\u1ec1u ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p tr\u00ean h\u00e0ng tri\u1ec7u ng\u01b0\u1eddi. M\u1ed1i li\u00ean h\u1ec7 n\u00e0y bao tr\u00f9m nhi\u1ec1u c\u0103n b\u1ec7nh m\u1ea1n t\u00ednh ph\u1ed5 bi\u1ebfn nh\u1ea5t v\u00e0 gi\u1eef v\u1eefng tr\u00ean nhi\u1ec1u nh\u00f3m d\u00e2n s\u1ed1, ch\u1ee7ng lo\u1ea1i c\u00e0 ph\u00ea c\u0169ng nh\u01b0 ph\u01b0\u01a1ng ph\u00e1p pha, cho th\u1ea5y c\u00f3 nh\u1eefng c\u01a1 ch\u1ebf sinh h\u1ecdc th\u1ef1c s\u1ef1 \u0111ang di\u1ec5n ra.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nh\u1eefng b\u1eb1ng ch\u1ee9ng nh\u1ea5t qu\u00e1n nh\u1ea5t t\u1eadp trung quanh 5 nh\u00f3m b\u1ec7nh l\u00fd:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>B\u1ec7nh Parkinson<\/strong> \u2014 th\u00f3i quen u\u1ed1ng c\u00e0 ph\u00ea \u0111\u1ec1u \u0111\u1eb7n g\u1eafn li\u1ec1n v\u1edbi t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh th\u1ea5p h\u01a1n r\u00f5 r\u1ec7t, trong \u0111\u00f3 caffeine \u0111\u00f3ng vai tr\u00f2 h\u1ea1t nh\u00e2n. C\u01a1 ch\u1ebf \u0111\u01b0\u1ee3c ch\u1ec9 ra l\u00e0 s\u1ef1 \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 adenosine tr\u00ean c\u00e1c n\u01a1-ron dopaminergic, gi\u00fap k\u00ecm h\u00e3m qu\u00e1 tr\u00ecnh tho\u00e1i h\u00f3a th\u1ea7n kinh.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>B\u1ec7nh Alzheimer<\/strong> \u2014 m\u1ed1i li\u00ean h\u1ec7 n\u00e0y hi\u1ec7n di\u1ec7n r\u00f5 r\u00e0ng d\u00f9 kh\u00f4ng ho\u00e0n to\u00e0n tuy\u1ebfn t\u00ednh nh\u01b0 \u1edf Parkinson. C\u1ea3 caffeine l\u1eabn axit chlorogenic \u0111\u1ec1u g\u00f3p ph\u1ea7n quan tr\u1ecdng th\u00f4ng qua c\u00e1c c\u01a1 ch\u1ebf x\u1eed l\u00fd m\u1ea3ng b\u00e1m amyloid v\u00e0 l\u00e0m d\u1ecbu t\u00ecnh tr\u1ea1ng vi\u00eam r\u1ec5 th\u1ea7n kinh.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>B\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng type 2<\/strong> \u2014 \u0111\u00e2y c\u00f3 l\u1ebd l\u00e0 m\u1ed1i li\u00ean h\u1ec7 gi\u00e0u d\u1eef li\u1ec7u nh\u1ea5t trong d\u1ecbch t\u1ec5 h\u1ecdc c\u00e0 ph\u00ea. M\u1ed9t <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24459154\/\" rel=\"nofollow noopener\" target=\"_blank\"><u><strong>b\u00e0i t\u1ed5ng quan h\u1ec7 th\u1ed1ng v\u00e0 ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p li\u1ec1u-\u0111\u00e1p \u1ee9ng tr\u00ean PLOS ONE<\/strong><\/u><\/a> ph\u00e1t hi\u1ec7n c\u1ea3 c\u00e0 ph\u00ea th\u01b0\u1eddng l\u1eabn c\u00e0 ph\u00ea decaf \u0111\u1ec1u gi\u00fap gi\u1ea3m nguy c\u01a1 ti\u1ec3u \u0111\u01b0\u1eddng type 2 \u2014 ph\u00e1t hi\u1ec7n tr\u00ean d\u00f2ng decaf ch\u1ec9 th\u1eb3ng v\u00e0o axit chlorogenic v\u00e0 trigonelline l\u00e0 c\u00e1c ho\u1ea1t ch\u1ea5t ch\u00ednh ch\u1ee9 kh\u00f4ng ph\u1ea3i caffeine. M\u1ed7i t\u00e1ch u\u1ed1ng th\u00eam m\u1ed7i ng\u00e0y t\u01b0\u01a1ng \u1ee9ng v\u1edbi m\u1ee9c gi\u1ea3m r\u1ee7i ro l\u0169y ti\u1ebfn c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>X\u01a1 h\u00f3a gan v\u00e0 x\u01a1 gan<\/strong> \u2014 m\u1ed1i li\u00ean h\u1ec7 v\u1edbi gan c\u1ef1c k\u1ef3 m\u1ea1nh m\u1ebd v\u00e0 \u0111\u01b0\u1ee3c h\u1ed7 tr\u1ee3 v\u1eefng ch\u1eafc v\u1ec1 m\u1eb7t c\u01a1 ch\u1ebf ph\u00e2n t\u1eed. U\u1ed1ng c\u00e0 ph\u00ea th\u01b0\u1eddng xuy\u00ean li\u00ean t\u1ee5c g\u1eafn li\u1ec1n v\u1edbi t\u1ef7 l\u1ec7 x\u01a1 gan, x\u01a1 h\u00f3a v\u00e0 ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o gan th\u1ea5p h\u01a1n r\u00f5 r\u1ec7t, trong \u0111\u00f3 axit chlorogenic v\u00e0 melanoidin \u0111\u00f3ng vai tr\u00f2 b\u1ea3o v\u1ec7 t\u1ebf b\u00e0o gan then ch\u1ed1t.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng<\/strong> \u2014 m\u1ed1i li\u00ean h\u1ec7 b\u1ea3o v\u1ec7 c\u00f3 t\u1ed3n t\u1ea1i, d\u00f9 quy m\u00f4 hi\u1ec7u \u1ee9ng khi\u00eam t\u1ed1n h\u01a1n v\u00e0 \u00edt \u0111\u1ed3ng nh\u1ea5t h\u01a1n so v\u1edbi k\u1ebft qu\u1ea3 chuy\u1ec3n h\u00f3a v\u00e0 tho\u00e1i h\u00f3a th\u1ea7n kinh.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.mdpi.com\/journal\/nutrients\" rel=\"nofollow noopener\" target=\"_blank\"><u><strong>GS. Adriana Farah<\/strong><\/u><\/a>, Gi\u00e1o s\u01b0 Khoa h\u1ecdc Th\u1ef1c ph\u1ea9m v\u00e0 Dinh d\u01b0\u1ee1ng t\u1ea1i \u0110\u1ea1i h\u1ecdc Li\u00ean bang Rio de Janeiro, t\u00f3m l\u01b0\u1ee3c b\u1ee9c tranh nghi\u00ean c\u1ee9u hi\u1ec7n t\u1ea1i: b\u1eb1ng ch\u1ee9ng t\u1eeb nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec5, th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u00e0 ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p \u0111\u1ec1u ch\u1ec9 ra th\u00f3i quen u\u1ed1ng c\u00e0 ph\u00ea \u0111i\u1ec1u \u0111\u1ed9 gi\u00fap gi\u1ea3m t\u1ef7 l\u1ec7 m\u1eafc ti\u1ec3u \u0111\u01b0\u1eddng type 2, Parkinson, Alzheimer, b\u1ec7nh gan, m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0 v\u00e0 \u0111\u1ed9t qu\u1ef5 \u2014 nh\u1eefng t\u00e1c \u0111\u1ed9ng n\u00e0y ch\u1ee7 y\u1ebfu nh\u1edd v\u00e0o \u0111\u1eb7c t\u00ednh ch\u1ed1ng oxy h\u00f3a v\u00e0 kh\u00e1ng vi\u00eam c\u1ee7a ma tr\u1eadn ho\u1ea1t t\u00ednh sinh h\u1ecdc, ch\u1ee9 kh\u00f4ng ri\u00eang g\u00ec caffeine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">M\u1ed9t l\u01b0u \u00fd thi\u1ebft y\u1ebfu: h\u1ea7u h\u1ebft c\u00e1c d\u1eef li\u1ec7u n\u00e0y mang t\u00ednh quan s\u00e1t d\u1ecbch t\u1ec5 h\u1ecdc, ngh\u0129a l\u00e0 ch\u00fang ta \u0111ang l\u00e0m vi\u1ec7c v\u1edbi c\u00e1c m\u1ed1i t\u01b0\u01a1ng quan ch\u1ee9 ch\u01b0a th\u1ec3 kh\u1eb3ng \u0111\u1ecbnh 100% quan h\u1ec7 nh\u00e2n qu\u1ea3. \u0110\u1ed9 l\u1edbn c\u1ee7a hi\u1ec7u qu\u1ea3 c\u00f2n t\u00f9y thu\u1ed9c v\u00e0o t\u1eebng nh\u00f3m d\u00e2n s\u1ed1, lo\u1ea1i c\u00e0 ph\u00ea v\u00e0 c\u01a1 \u0111\u1ecba di truy\u1ec1n m\u1ed7i ng\u01b0\u1eddi. D\u00f9 kh\u00f4ng ph\u1ea3i chi\u1ebfc ch\u00eca kh\u00f3a v\u1ea1n n\u0103ng hay \u0111\u01a1n thu\u1ed1c ch\u1eefa b\u00e1ch b\u1ec7nh, s\u1ef1 \u0111\u1ed3ng nh\u1ea5t \u0111\u00e1ng kinh ng\u1ea1c gi\u1eefa c\u00e1c nghi\u00ean c\u1ee9u \u0111\u1ed9c l\u1eadp k\u1ebft h\u1ee3p c\u00f9ng c\u01a1 ch\u1ebf ph\u00e2n t\u1eed r\u00f5 r\u00e0ng \u0111\u00e3 bi\u1ebfn c\u00e0 ph\u00ea th\u00e0nh th\u1ee9c u\u1ed1ng c\u00f3 gi\u00e1 tr\u1ecb s\u1ee9c kh\u1ecfe th\u1ef1c s\u1ef1 thuy\u1ebft ph\u1ee5c.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">C\u00e1ch C\u00e0 Ph\u00ea B\u1ea3o V\u1ec7 B\u1ea1n: C\u00e1c C\u01a1 Ch\u1ebf Ph\u00e2n T\u1eed<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u ho\u1ea1t t\u00ednh sinh h\u1ecdc c\u1ee7a c\u00e0 ph\u00ea can thi\u1ec7p s\u00e2u \u1edf c\u1ea5p \u0111\u1ed9 bi\u1ec3u hi\u1ec7n gen, ho\u1ea1t t\u00ednh enzyme v\u00e0 c\u1ea3m bi\u1ebfn n\u0103ng l\u01b0\u1ee3ng t\u1ebf b\u00e0o \u2014 v\u01b0\u1ee3t xa l\u1eddi gi\u1ea3i th\u00edch gi\u1ea3n \u0111\u01a1n th\u01b0\u1eddng th\u1ea5y l\u00e0 &#8220;ch\u1ea5t ch\u1ed1ng oxy h\u00f3a \u0111i d\u1ecdn d\u1eb9p g\u1ed1c t\u1ef1 do&#8221;. B\u1ee9c tranh th\u1ef1c t\u1ebf l\u00e0 s\u1ef1 k\u00edch ho\u1ea1t c\u00e1c y\u1ebfu t\u1ed1 phi\u00ean m\u00e3 \u0111\u1eb7c hi\u1ec7u, \u0111\u00e1nh th\u1ee9c c\u00e1c c\u1ea3m bi\u1ebfn trao \u0111\u1ed5i ch\u1ea5t v\u00e0 kh\u1edfi \u0111\u1ed9ng chu\u1ed7i ph\u1ea3n \u1ee9ng gi\u00fap t\u1ebf b\u00e0o gan x\u1eed l\u00fd ch\u1ea5t b\u00e9o, \u0111\u01b0\u1eddng v\u00e0 t\u1ea3i l\u01b0\u1ee3ng oxy h\u00f3a. Hai con \u0111\u01b0\u1eddng h\u1ea1t nh\u00e2n \u2014 Nrf2 v\u00e0 AMPK \u2014 ng\u1ef1 tr\u1ecb ngay t\u1ea1i trung t\u00e2m c\u1ee7a m\u1ecdi t\u00e1c \u0111\u1ed9ng t\u1ebf b\u00e0o \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Nrf2 v\u00e0 AMPK: Nh\u1eefng C\u00f4ng T\u1eafc Ph\u00e2n T\u1eed B\u1eadt Kh\u00e1ng Th\u1ec3 T\u1ebf B\u00e0o C\u1ee7a C\u00e0 Ph\u00ea<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">L\u00e1 gan l\u00e0 m\u1eb7t tr\u1eadn h\u00e0ng \u0111\u1ea7u ti\u1ebfp nh\u1eadn l\u1ee3i \u00edch chuy\u1ec3n h\u00f3a t\u1eeb c\u00e0 ph\u00ea, v\u00e0 hai c\u00f4ng t\u1eafc ph\u00e2n t\u1eed c\u1ed1t l\u00f5i gi\u1ea3i th\u00edch ph\u1ea7n l\u1edbn t\u00e1c \u0111\u1ed9ng n\u00e0y ch\u00ednh l\u00e0 con \u0111\u01b0\u1eddng ch\u1ed1ng oxy h\u00f3a Nrf2 c\u00f9ng con \u0111\u01b0\u1eddng c\u1ea3m bi\u1ebfn n\u0103ng l\u01b0\u1ee3ng AMPK \u2014 c\u1ea3 hai \u0111\u1ec1u \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t tr\u1ef1c ti\u1ebfp b\u1edfi axit chlorogenic v\u00e0 c\u00e1c polyphenol li\u00ean quan. Khi hai con \u0111\u01b0\u1eddng n\u00e0y v\u1eadn h\u00e0nh, hi\u1ec7u qu\u1ea3 t\u1ea1o ra v\u01b0\u1ee3t tr\u1ed9i h\u01a1n h\u1eb3n kh\u1ea3 n\u0103ng ch\u1ed1ng oxy h\u00f3a \u0111\u01a1n thu\u1ea7n.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nrf2 \u2014 y\u1ebfu t\u1ed1 phi\u00ean m\u00e3 li\u00ean quan \u0111\u1ebfn nh\u00e2n t\u1ebf b\u00e0o erythroid 2 \u2014 gi\u1eef vai tr\u00f2 t\u1ed5ng ch\u1ec9 huy m\u1ea1ng l\u01b0\u1edbi ch\u1ed1ng oxy h\u00f3a n\u1ed9i sinh. Trong \u0111i\u1ec1u ki\u1ec7n b\u00ecnh th\u01b0\u1eddng, Nrf2 n\u1eb1m im l\u00ecm trong t\u1ebf b\u00e0o ch\u1ea5t. Khi axit chlorogenic ho\u1eb7c c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a ch\u00fang t\u1eeb \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ebfn \u0111\u01b0\u1ee3c t\u1ebf b\u00e0o gan, ch\u00fang k\u00edch ho\u1ea1t s\u1ef1 thay \u0111\u1ed5i c\u1ea5u tr\u00fac gi\u00fap gi\u1ea3i ph\u00f3ng Nrf2, cho ph\u00e9p n\u00f3 di chuy\u1ec3n v\u00e0o nh\u00e2n t\u1ebf b\u00e0o v\u00e0 li\u00ean k\u1ebft v\u1edbi c\u00e1c y\u1ebfu t\u1ed1 ph\u1ea3n \u1ee9ng ch\u1ed1ng oxy h\u00f3a (ARE) tr\u00ean chu\u1ed7i DNA. \u0110i\u1ec1u n\u00e0y \u0111\u00e1nh th\u1ee9c h\u00e0ng lo\u1ea1t enzyme ph\u00f2ng v\u1ec7 \u0111\u1ed3ng b\u1ed9 nh\u01b0 superoxide dismutase v\u00e0 catalase. K\u1ebft qu\u1ea3 kh\u00f4ng ch\u1ec9 l\u00e0 m\u1ed9t ph\u1ea3n \u1ee9ng ch\u1ed1ng oxy h\u00f3a l\u1ebb t\u1ebb, m\u00e0 l\u00e0 s\u1ef1 k\u00edch ho\u1ea1t to\u00e0n di\u1ec7n m\u1ed9t ch\u01b0\u01a1ng tr\u00ecnh gen ph\u00f2ng th\u1ee7 ki\u00ean c\u1ed1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tr\u1ee5c AMPK-SREBP-1c l\u1ea1i \u0111\u1ea3m \u0111\u01b0\u01a1ng ph\u01b0\u01a1ng di\u1ec7n c\u00e2n b\u1eb1ng chuy\u1ec3n h\u00f3a. AMPK (AMP-activated protein kinase) \u0111\u00f3ng vai tr\u00f2 nh\u01b0 chi\u1ebfc \u0111\u1ed3ng h\u1ed3 \u0111o nhi\u00ean li\u1ec7u c\u1ee7a t\u1ebf b\u00e0o \u2014 n\u00f3 b\u1eadt l\u00ean khi n\u0103ng l\u01b0\u1ee3ng t\u1ebf b\u00e0o c\u1ea1n ki\u1ec7t \u0111\u1ec3 ph\u1ee5c h\u1ed3i l\u1ea1i c\u00e2n b\u1eb1ng n\u1ed9i m\u00f4i. Axit chlorogenic k\u00edch ho\u1ea1t AMPK trong t\u1ebf b\u00e0o gan, t\u1eeb \u0111\u00f3 \u1ee9c ch\u1ebf SREBP-1c \u2014 y\u1ebfu t\u1ed1 phi\u00ean m\u00e3 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p ch\u1ea5t b\u00e9o t\u1ea1i gan. T\u00e1c \u0111\u1ed9ng k\u00e9p mang l\u1ea1i l\u00e0 gi\u1ea3m t\u00edch t\u1ee5 m\u1ee1 trong gan v\u00e0 c\u1ea3i thi\u1ec7n \u0111\u1ed9 nh\u1ea1y insulin, gi\u1ea3i th\u00edch v\u00ec sao c\u00e0 ph\u00ea l\u1ea1i g\u1eafn b\u00f3 m\u1eadt thi\u1ebft v\u1edbi vi\u1ec7c gi\u1ea3m nguy c\u01a1 ti\u1ec3u \u0111\u01b0\u1eddng type 2 v\u00e0 gan nhi\u1ec5m m\u1ee1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trigonelline \u0111\u00f3ng g\u00f3p m\u1ed9t c\u01a1 ch\u1ebf b\u1ed5 tr\u1ee3 \u0111\u1ed9c \u0111\u00e1o kh\u00e1c. Trong qu\u00e1 tr\u00ecnh rang, m\u1ed9t ph\u1ea7n trigonelline ph\u00e2n r\u00e3 th\u00e0nh axit nicotinic \u2014 d\u1ea1ng niacin tham gia tr\u1ef1c ti\u1ebfp v\u00e0o qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p NAD\u207a, coenzyme s\u1ed1ng c\u00f2n cho h\u00f4 h\u1ea5p n\u0103ng l\u01b0\u1ee3ng ti th\u1ec3. \u0110i\u1ec1u n\u00e0y \u0111\u1ed3ng ngh\u0129a v\u1edbi vi\u1ec7c c\u00e0 ph\u00ea rang \u0111\u1eadm mang l\u1ea1i ngu\u1ed3n l\u1ef1c gi\u00fap ti\u1ebfp s\u1ee9c cho qu\u00e1 tr\u00ecnh s\u1ea3n sinh n\u0103ng l\u01b0\u1ee3ng t\u1ebf b\u00e0o v\u00e0 d\u1eabn truy\u1ec1n t\u00edn hi\u1ec7u insulin c\u00f9ng l\u00fac.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.frontiersin.org\/journals\/nutrition\" rel=\"nofollow noopener\" target=\"_blank\"><u><strong>GS. Elvira Gonzalez de Mejia<\/strong><\/u><\/a> c\u00f9ng c\u1ed9ng s\u1ef1 t\u1ea1i \u0110\u1ea1i h\u1ecdc Illinois \u0111\u00e3 x\u00e1c \u0111\u1ecbnh c\u00e1ch c\u00e1c ho\u1ea1t ch\u1ea5t t\u1eeb ph\u1ee5 ph\u1ea9m c\u00e0 ph\u00ea \u2014 ch\u1ee7 y\u1ebfu l\u00e0 axit chlorogenic v\u00e0 axit protocatechuic \u2014 k\u00edch ho\u1ea1t chu\u1ed7i t\u00edn hi\u1ec7u FGF21 trong t\u1ebf b\u00e0o gan, v\u1eeba \u0111i\u1ec1u h\u00f2a ch\u1ee9c n\u0103ng ti th\u1ec3 gan v\u1eeba t\u1ed1i \u01b0u h\u00f3a chuy\u1ec3n h\u00f3a lipid v\u00e0 glucose. C\u00f4ng tr\u00ecnh c\u0169ng ghi nh\u1eadn c\u00e1c d\u1ea5u \u1ea5n c\u0103ng th\u1eb3ng oxy h\u00f3a (bao g\u1ed3m c\u00e1c g\u1ed1c oxy ph\u1ea3n \u1ee9ng ROS v\u00e0 superoxide ti th\u1ec3) b\u1ecb tri\u1ec7t ti\u00eau th\u00f4ng qua k\u00edch ho\u1ea1t Nrf2, \u0111\u1ed3ng th\u1eddi t\u0103ng c\u01b0\u1eddng ho\u1ea1t t\u00ednh enzyme ch\u1ed1ng oxy h\u00f3a \u2014 kh\u1eb3ng \u0111\u1ecbnh \u0111\u00e2y l\u00e0 nh\u1eefng c\u01a1 ch\u1ebf ph\u00e2n t\u1eed c\u00f3 th\u1ec3 \u0111o l\u01b0\u1eddng ch\u00ednh x\u00e1c ch\u1ee9 kh\u00f4ng ph\u1ea3i suy \u0111o\u00e1n tr\u00ean l\u00fd thuy\u1ebft.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">L\u01b0\u1ee3ng H\u00f3a T\u00e1c \u0110\u1ed9ng: C\u00e1c Con S\u1ed1 Th\u1ef1c T\u1ebf Trong T\u1ebf B\u00e0o Gan<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Chu\u1ed7i t\u00edn hi\u1ec7u FGF21 n\u1eb1m \u1edf h\u1ea1 l\u01b0u c\u1ee7a c\u1ea3 hai qu\u00e1 tr\u00ecnh k\u00edch ho\u1ea1t Nrf2 v\u00e0 AMPK, \u0111\u00f3ng vai tr\u00f2 nh\u01b0 ch\u1ec9 s\u1ed1 \u0111o l\u01b0\u1eddng chu\u1ea9n x\u00e1c cho t\u00e1c \u0111\u1ed9ng chuy\u1ec3n h\u00f3a t\u1ed5ng th\u1ec3 c\u1ee7a c\u00e1c ho\u1ea1t ch\u1ea5t c\u00e0 ph\u00ea \u2014 c\u00e1c th\u1eed nghi\u1ec7m nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o g\u1ea7n \u0111\u00e2y \u0111\u00e3 chuy\u1ec3n cu\u1ed9c th\u1ea3o lu\u1eadn t\u1eeb m\u00f4 t\u1ea3 \u0111\u1ecbnh t\u00ednh sang c\u00e1c con s\u1ed1 nh\u00e2n b\u1ed9i c\u1ee5 th\u1ec3 \u0111\u1ea7y thuy\u1ebft ph\u1ee5c.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">M\u1ed9t <a href=\"https:\/\/www.frontiersin.org\/journals\/nutrition\/articles\/10.3389\/fnut.2022.866233\/full\" rel=\"nofollow noopener\" target=\"_blank\"><u><strong>nghi\u00ean c\u1ee9u n\u0103m 2022 tr\u00ean Frontiers in Nutrition<\/strong><\/u><\/a> \u0111\u00e3 s\u1eed d\u1ee5ng t\u1ebf b\u00e0o gan HepG2 \u0111\u01b0\u1ee3c x\u1eed l\u00fd b\u1eb1ng axit palmitic \u0111\u1ec3 m\u00f4 ph\u1ecfng b\u1ec7nh gan nhi\u1ec5m m\u1ee1 kh\u00f4ng do r\u01b0\u1ee3u (NAFLD), sau \u0111\u00f3 cho c\u00e1c t\u1ebf b\u00e0o ti\u1ebfp x\u00fac v\u1edbi axit chlorogenic v\u00e0 axit protocatechuic \u1edf n\u1ed3ng \u0111\u1ed9 50 \u00b5mol\/L, c\u00f9ng d\u1ecbch chi\u1ebft xu\u1ea5t n\u01b0\u1edbc \u1edf m\u1ee9c 100 \u00b5g\/mL. K\u1ebft qu\u1ea3 l\u01b0\u1ee3ng h\u00f3a tr\u00ean nhi\u1ec1u ch\u1ec9 s\u1ed1 chuy\u1ec3n h\u00f3a: l\u01b0\u1ee3ng ti\u1ebft FGF21 t\u0103ng t\u1eeb 1,3 \u0111\u1ebfn 1,9 l\u1ea7n; t\u00edch t\u1ee5 lipid n\u1ed9i b\u00e0o gi\u1ea3m 23\u201341%; v\u00e0 kh\u1ea3 n\u0103ng h\u1ea5p thu glucose c\u1ea3i thi\u1ec7n t\u1eeb 58\u2013111%. Ho\u1ea1t t\u00ednh Carnitine palmitoyl-transferase-1 \u2014 enzyme then ch\u1ed1t trong qu\u00e1 tr\u00ecnh oxy h\u00f3a axit b\u00e9o \u2014 t\u0103ng 1,3 \u0111\u1ebfn 1,7 l\u1ea7n, \u0111\u1ed3ng th\u1eddi con \u0111\u01b0\u1eddng t\u00edn hi\u1ec7u insulin IRS-1\/Akt1 \u0111\u01b0\u1ee3c \u0111i\u1ec1u h\u00f2a r\u00f5 r\u1ec7t.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00f3 hai \u0111i\u1ec3m l\u00e0m cho c\u00e1c con s\u1ed1 n\u00e0y mang \u00fd ngh\u0129a v\u01b0\u1ee3t kh\u1ecfi ph\u1ea1m vi ph\u00f2ng th\u00ed nghi\u1ec7m. Th\u1ee9 nh\u1ea5t, n\u1ed3ng \u0111\u1ed9 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong th\u1eed nghi\u1ec7m t\u01b0\u01a1ng \u0111\u1ed3ng v\u1edbi m\u1ee9c ho\u00e0n to\u00e0n c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c qua vi\u1ec7c u\u1ed1ng c\u00e0 ph\u00ea h\u00e0ng ng\u00e0y \u2014 m\u1ed9t t\u00e1ch c\u00e0 ph\u00ea ph\u1ec5u l\u1ecdc c\u00f3 th\u1ec3 cung c\u1ea5p 50\u2013200 mg axit chlorogenic, \u0111\u01b0a th\u00f3i quen u\u1ed1ng 2-3 t\u00e1ch m\u1ed7i ng\u00e0y v\u00e0o \u0111\u00fang ph\u1ea1m vi ho\u1ea1t t\u00ednh sinh h\u1ecdc c\u1ee7a m\u00f4 h\u00ecnh. Th\u1ee9 hai, c\u00e1c hi\u1ec7u \u1ee9ng h\u1ed9i t\u1ee5 t\u1ea1i ch\u1ee9c n\u0103ng h\u00f4 h\u1ea5p c\u1ee7a ti th\u1ec3: k\u00edch ho\u1ea1t FGF21 c\u1ea3i thi\u1ec7n n\u0103ng l\u01b0\u1ee3ng sinh h\u1ecdc ti th\u1ec3 trong c\u00e1c t\u1ebf b\u00e0o qu\u00e1 t\u1ea3i m\u1ee1, li\u00ean k\u1ebft tr\u1ef1c ti\u1ebfp vi\u1ec7c ti\u1ebfp x\u00fac ho\u1ea1t ch\u1ea5t c\u00e0 ph\u00ea v\u1edbi t\u0103ng c\u01b0\u1eddng chuy\u1ec3n h\u00f3a n\u0103ng l\u01b0\u1ee3ng t\u1ebf b\u00e0o. \u0110\u00e2y l\u00e0 m\u1eaft x\u00edch s\u1ed1ng c\u00f2n k\u1ebft n\u1ed1i d\u1eef li\u1ec7u nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o v\u1edbi c\u00e1c quan s\u00e1t d\u1ecbch t\u1ec5 quy m\u00f4 l\u1edbn.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0110\u00f3 ch\u00ednh l\u00e0 s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa vi\u1ec7c hi\u1ec3u r\u00f5 c\u01a1 ch\u1ebf v\u00e0 s\u1ef1 suy \u0111o\u00e1n t\u01b0\u01a1ng quan: h\u00e0nh tr\u00ecnh t\u1eeb t\u00e1ch c\u00e0 ph\u00ea \u0111\u1ebfn t\u1eebng t\u1ebf b\u00e0o gi\u1edd \u0111\u00e2y \u0111\u00e3 c\u00f3 th\u1ec3 l\u1ea7n d\u1ea5u b\u1eb1ng nh\u1eefng con s\u1ed1 \u0111\u1ecbnh l\u01b0\u1ee3ng v\u1eefng ch\u1eafc.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Rang C\u00e0 Ph\u00ea: Ph\u00e9p Thu\u1eadt Nhi\u1ec7t Bi\u1ebfn \u0110\u1ed5i Ho\u1ea1t T\u00ednh Sinh H\u1ecdc<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">H\u00f3a h\u1ecdc c\u1ee7a qu\u00e1 tr\u00ecnh rang c\u00e0 ph\u00ea l\u00e0 m\u1ed9t chu\u1ed7i bi\u1ebfn \u0111\u1ed5i b\u1ea5t kh\u1ea3 ngh\u1ecbch, v\u1eeba ph\u00e1 h\u1ee7y m\u1ed9t s\u1ed1 ho\u1ea1t ch\u1ea5t sinh h\u1ecdc, v\u1eeba khai sinh ra nh\u1eefng h\u1ee3p ch\u1ea5t m\u1edbi toanh, \u0111\u1ed3ng th\u1eddi bi\u1ebfn \u0111\u1ed5i c\u00e1c ch\u1ea5t kh\u00e1c th\u00e0nh nh\u1eefng d\u1ea1ng ph\u00e2n t\u1eed c\u00f3 vai tr\u00f2 sinh l\u00fd ho\u00e0n to\u00e0n m\u1edbi \u2014 \u0111i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a c\u1ea5p \u0111\u1ed9 rang b\u1ea1n ch\u1ecdn ch\u00ednh l\u00e0 quy\u1ebft \u0111\u1ecbnh b\u1ea1n \u0111ang \u01b0u ti\u00ean nh\u00f3m ho\u1ea1t ch\u1ea5t n\u00e0o cho c\u01a1 th\u1ec3 m\u00ecnh.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">S\u1ef1 bi\u1ebfn \u0111\u1ed5i quan tr\u1ecdng nh\u1ea5t di\u1ec5n ra \u1edf axit chlorogenic. H\u1ea1t c\u00e0 ph\u00ea nh\u00e2n xanh ch\u1ee9a l\u01b0\u1ee3ng CGA c\u1ef1c k\u1ef3 d\u1ed3i d\u00e0o \u2014 chi\u1ebfm t\u1edbi 12% tr\u1ecdng l\u01b0\u1ee3ng kh\u00f4 \u1edf m\u1ed9t s\u1ed1 gi\u1ed1ng. Qu\u00e1 tr\u00ecnh rang nhi\u1ec7t s\u1ebd ph\u00e2n h\u1ee7y d\u1ea7n CGA qua hi\u1ec7n t\u01b0\u1ee3ng nhi\u1ec7t ph\u00e2n: c\u00e1c ph\u00e2n t\u1eed CGA v\u1ee1 v\u1ee5n t\u1ea1o th\u00e0nh cinnamoyl quinolactone c\u00f9ng c\u00e1c d\u1eabn xu\u1ea5t phenolic kh\u00e1c. Khi b\u01b0\u1edbc sang c\u1ea5p \u0111\u1ed9 rang \u0111\u1eadm (dark roast), l\u01b0\u1ee3ng CGA c\u00f3 th\u1ec3 hao h\u1ee5t t\u1eeb 50% tr\u1edf l\u00ean so v\u1edbi ban \u0111\u1ea7u. C\u00e1c m\u1ee9c rang nh\u1ea1t (light roast) gi\u1eef l\u1ea1i nhi\u1ec1u CGA nh\u1ea5t \u2014 l\u1ef1a ch\u1ecdn l\u00fd t\u01b0\u1edfng n\u1ebfu m\u1ee5c ti\u00eau h\u00e0ng \u0111\u1ea7u c\u1ee7a b\u1ea1n l\u00e0 l\u1ee3i \u00edch chuy\u1ec3n h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 gan.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.mdpi.com\/journal\/nutrients\" rel=\"nofollow noopener\" target=\"_blank\"><u><strong>GS. Adriana Farah<\/strong><\/u><\/a> \u0111\u00e3 m\u00f4 t\u1ea3 chi ti\u1ebft qu\u00e1 tr\u00ecnh n\u00e0y: d\u01b0\u1edbi t\u00e1c \u0111\u1ed9ng nhi\u1ec7t, CGA tr\u1ea3i qua ph\u1ea3n \u1ee9ng nhi\u1ec7t ph\u00e2n t\u1ea1o ra c\u00e1c lactone phenolic v\u00e0 nhi\u1ec1u d\u1eabn xu\u1ea5t, trong \u0111\u00f3 cinnamoyl-1,5-\u03b3-quinolactone (CGL) l\u00e0 s\u1ea3n ph\u1ea9m ch\u00ednh \u2014 h\u00ecnh th\u00e0nh th\u00f4ng qua li\u00ean k\u1ebft ester n\u1ed9i ph\u00e2n t\u1eed khi ph\u00e2n t\u1eed m\u1ea5t n\u01b0\u1edbc. C\u00e1c d\u1eabn xu\u1ea5t n\u00e0y v\u1eabn duy tr\u00ec kh\u1ea3 n\u0103ng ch\u1ed1ng oxy h\u00f3a nh\u1ea5t \u0111\u1ecbnh nh\u01b0ng \u0111\u1ea1i di\u1ec7n cho m\u1ed9t nh\u00f3m h\u1ee3p ch\u1ea5t c\u00f3 c\u1ea5u tr\u00fac v\u00e0 d\u01b0\u1ee3c t\u00ednh kh\u00e1c bi\u1ec7t so v\u1edbi CGA nguy\u00ean b\u1ea3n.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">B\u00f9 tr\u1eeb cho s\u1ef1 s\u1ee5t gi\u1ea3m c\u1ee7a CGA l\u00e0 s\u1ef1 ra \u0111\u1eddi c\u1ee7a melanoidin. Khi \u0111\u1ed9 rang t\u0103ng d\u1ea7n, ph\u1ea3n \u1ee9ng Maillard gi\u1eefa \u0111\u01b0\u1eddng kh\u1eed v\u00e0 axit amin s\u1ebd s\u1ea3n sinh ra melanoidin \u2014 c\u00e1c polymer s\u1eabm m\u00e0u tr\u1ecdng l\u01b0\u1ee3ng ph\u00e2n t\u1eed cao t\u1ea1o n\u00ean s\u1eafc n\u00e2u \u00f3ng \u1ea3 v\u00e0 \u0111\u1ed9 \u0111\u1ea7m (body) cho c\u00e0 ph\u00ea rang \u0111\u1eadm. Ch\u00fang kh\u00f4ng ph\u1ea3i l\u00e0 ph\u1ebf ph\u1ea9m c\u1ee7a s\u1ef1 ph\u00e2n h\u1ee7y, m\u00e0 l\u00e0 c\u00e1c ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc \u0111\u00f3ng vai tr\u00f2 nh\u01b0 ch\u1ea5t x\u01a1 ch\u1ed1ng oxy h\u00f3a trong \u0111\u01b0\u1eddng ru\u1ed9t. Nh\u01b0 v\u1eady, d\u00f9 m\u1ea5t b\u1edbt CGA, c\u00e0 ph\u00ea rang \u0111\u1eadm l\u1ea1i gi\u00e0u th\u00eam melanoidin \u2014 m\u1ed9t h\u1ed3 s\u01a1 ho\u1ea1t ch\u1ea5t kh\u00e1c bi\u1ec7t ch\u1ee9 kh\u00f4ng h\u1ec1 k\u00e9m c\u1ea1nh.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hai thay \u0111\u1ed5i ph\u1ee5 thu\u1ed9c v\u00e0o m\u1ee9c rang kh\u00e1c c\u0169ng r\u1ea5t \u0111\u00e1ng l\u01b0u \u00fd: Caffeine c\u1ef1c k\u1ef3 \u1ed5n \u0111\u1ecbnh nhi\u1ec7t: t\u00ednh theo tr\u1ecdng l\u01b0\u1ee3ng, h\u00e0m l\u01b0\u1ee3ng caffeine h\u1ea7u nh\u01b0 kh\u00f4ng thay \u0111\u1ed5i d\u00f9 rang nh\u1ea1t hay \u0111\u1eadm. Ni\u1ec1m tin cho r\u1eb1ng c\u00e0 ph\u00ea rang \u0111\u1eadm &#8220;nhi\u1ec1u caffeine h\u01a1n&#8221; th\u1ef1c ch\u1ea5t ch\u1ec9 l\u00e0 \u1ea3o gi\u00e1c \u0111ong theo th\u1ec3 t\u00edch \u2014 h\u1ea1t rang \u0111\u1eadm n\u1edf to v\u00e0 x\u1ed1p h\u01a1n, n\u00ean m\u1ed9t mu\u1ed7ng g\u1ea1t rang \u0111\u1eadm s\u1ebd ch\u1ee9a \u00edt h\u1ea1t theo kh\u1ed1i l\u01b0\u1ee3ng h\u01a1n so v\u1edbi rang nh\u1ea1t, do \u0111\u00f3 n\u1ea1p \u00edt caffeine h\u01a1n tr\u00ean m\u1ed7i mu\u1ed7ng nh\u01b0ng t\u01b0\u01a1ng \u0111\u01b0\u01a1ng tr\u00ean m\u1ed7i gram. Ng\u01b0\u1ee3c l\u1ea1i, trigonelline l\u1ea1i nh\u1ea1y c\u1ea3m v\u1edbi nhi\u1ec7t: n\u00f3 chuy\u1ec3n h\u00f3a m\u1ed9t ph\u1ea7n th\u00e0nh axit nicotinic khi rang, \u0111\u1ed3ng ngh\u0129a v\u1edbi vi\u1ec7c ly c\u00e0 ph\u00ea rang \u0111\u1eadm cung c\u1ea5p nhi\u1ec1u vitamin B3 (niacin) h\u01a1n ly rang nh\u1ea1t.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">B\u00e0i h\u1ecdc th\u1ef1c t\u1ebf t\u1eeb h\u00f3a h\u1ecdc rang c\u00e0 ph\u00ea l\u00e0: kh\u00f4ng c\u00f3 c\u1ea5p \u0111\u1ed9 rang n\u00e0o v\u01b0\u1ee3t tr\u1ed9i tuy\u1ec7t \u0111\u1ed1i cho s\u1ee9c kh\u1ecfe. Rang nh\u1ea1t t\u1ed1i \u01b0u h\u00f3a l\u01b0\u1ee3ng CGA; rang \u0111\u1eadm \u0111\u00e1nh \u0111\u1ed5i CGA \u0111\u1ec3 l\u1ea5y melanoidin v\u00e0 b\u1ed5 sung th\u00eam niacin. L\u1ef1a ch\u1ecdn chu\u1ea9n x\u00e1c t\u00f9y thu\u1ed9c v\u00e0o h\u1ecd ho\u1ea1t ch\u1ea5t m\u00e0 b\u1ea1n mu\u1ed1n c\u01a1 th\u1ec3 \u01b0u ti\u00ean h\u1ea5p thu.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"1536\" src=\"https:\/\/coffeefactz.com\/wp-content\/uploads\/2026\/06\/coffee-roasting-chemical-transformation-infographic.webp\" alt=\"Infographic showing coffee roasting process transforming chlorogenic acids and trigonelline into melanoidins and nicotinic acid\" class=\"wp-image-51152\" title=\"\" srcset=\"https:\/\/coffeefactz.com\/wp-content\/uploads\/2026\/06\/coffee-roasting-chemical-transformation-infographic.webp 1024w, https:\/\/coffeefactz.com\/wp-content\/uploads\/2026\/06\/coffee-roasting-chemical-transformation-infographic-200x300.webp 200w, https:\/\/coffeefactz.com\/wp-content\/uploads\/2026\/06\/coffee-roasting-chemical-transformation-infographic-683x1024.webp 683w, https:\/\/coffeefactz.com\/wp-content\/uploads\/2026\/06\/coffee-roasting-chemical-transformation-infographic-768x1152.webp 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">C\u00e1ch Pha C\u00e0 Ph\u00ea: L\u1ecdc Gi\u1ea5y Hay Kh\u00f4ng L\u1ecdc V\u00e0 B\u00e0i To\u00e1n Diterpene<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">K\u1ef9 thu\u1eadt pha ch\u1ebf l\u00e0 n\u01a1i kh\u00eda c\u1ea1nh s\u1ee9c kh\u1ecfe th\u1ec3 hi\u1ec7n r\u00f5 n\u00e9t nh\u1ea5t m\u00e0 c\u00e1c b\u00e0i vi\u1ebft ph\u1ed5 th\u00f4ng hi\u1ebfm khi \u0111\u00e0o s\u00e2u \u2014 b\u1edfi ph\u01b0\u01a1ng ph\u00e1p tr\u00edch xu\u1ea5t kh\u00f4ng ch\u1ec9 \u0111\u1ecbnh h\u00ecnh h\u01b0\u01a1ng v\u1ecb, m\u00e0 c\u00f2n quy\u1ebft \u0111\u1ecbnh h\u1ee3p ch\u1ea5t ho\u1ea1t t\u00ednh n\u00e0o s\u1ebd chui v\u00e0o ly c\u1ee7a b\u1ea1n v\u00e0 ch\u1ea5t n\u00e0o b\u1ecb gi\u1eef l\u1ea1i trong b\u00e3 ho\u1eb7c ph\u1ec5u l\u1ecdc. V\u1edbi \u0111a ph\u1ea7n c\u00e1c ch\u1ea5t, \u0111\u00e2y l\u00e0 b\u00e0i to\u00e1n t\u1ed1i \u01b0u h\u00f3a. Nh\u01b0ng ri\u00eang v\u1edbi diterpene, \u0111\u00f3 l\u00e0 c\u00e2u chuy\u1ec7n li\u00ean quan tr\u1ef1c ti\u1ebfp \u0111\u1ebfn r\u1ee7i ro tim m\u1ea1ch.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">M\u00e0ng L\u1ecdc V\u00e0 Diterpene: C\u00e1ch Pha Ch\u1ebf Th\u1ef1c S\u1ef1 Chi\u1ebft Xu\u1ea5t Nh\u1eefng G\u00ec<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Cafestol v\u00e0 kahweol l\u00e0 c\u00e1c diterpene tan trong d\u1ea7u n\u1eb1m \u1edf ph\u1ea7n ch\u1ea5t b\u00e9o lipid c\u1ee7a h\u1ea1t c\u00e0 ph\u00ea \u2014 vi\u1ec7c ch\u00fang c\u00f3 m\u1eb7t trong t\u00e1ch c\u1ee7a b\u1ea1n hay kh\u00f4ng ph\u1ee5 thu\u1ed9c g\u1ea7n nh\u01b0 tuy\u1ec7t \u0111\u1ed1i v\u00e0o vi\u1ec7c d\u1ee5ng c\u1ee5 pha c\u00f3 d\u00f9ng gi\u1ea5y l\u1ecdc hay kh\u00f4ng. \u0110\u00e2y l\u00e0 bi\u1ebfn s\u1ed1 quan tr\u1ecdng h\u00e0ng \u0111\u1ea7u t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn h\u1ed3 s\u01a1 tim m\u1ea1ch c\u1ee7a ng\u01b0\u1eddi u\u1ed1ng c\u00e0 ph\u00ea.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c ph\u01b0\u01a1ng ph\u00e1p l\u1ecdc b\u1eb1ng gi\u1ea5y \u2014 nh\u01b0 m\u00e1y pha nh\u1ecf gi\u1ecdt (drip), pour-over (V60, Chemex) hay AeroPress d\u00f9ng gi\u1ea5y l\u1ecdc \u2014 gi\u1eef l\u1ea1i ph\u1ea7n l\u1edbn l\u01b0\u1ee3ng v\u00e1ng d\u1ea7u h\u1eefu c\u01a1. K\u1ebft qu\u1ea3 l\u00e0 h\u01a1n 90% cafestol v\u00e0 kahweol b\u1ecb ch\u1eb7n \u0111\u1ee9ng l\u1ea1i \u1edf m\u00e0ng l\u1ecdc gi\u1ea5y, gi\u00fap t\u00e1ch c\u00e0 ph\u00ea th\u00e0nh ph\u1ea9m ho\u00e0n to\u00e0n trung t\u00ednh v\u1edbi ch\u1ec9 s\u1ed1 m\u1ee1 m\u00e1u LDL. Ng\u01b0\u1ee3c l\u1ea1i, c\u00e1c c\u00e1ch pha kh\u00f4ng d\u00f9ng gi\u1ea5y l\u1ecdc \u2014 nh\u01b0 b\u00ecnh French press, c\u00e0 ph\u00ea Th\u1ed5 Nh\u0129 K\u1ef3, c\u00e0 ph\u00ea \u0111un s\u00f4i ki\u1ec3u B\u1eafc \u00c2u v\u00e0 m\u1ed9t ph\u1ea7n espresso \u2014 cho ph\u00e9p l\u1edbp tinh d\u1ea7u n\u00e0y \u0111i th\u1eb3ng v\u00e0o ly, mang theo l\u01b0\u1ee3ng diterpene \u0111\u00e1ng k\u1ec3 trong t\u1eebng ng\u1ee5m u\u1ed1ng.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/journal\/food-research-international\" rel=\"nofollow noopener\" target=\"_blank\"><u><strong>TS. S. Moeenfard<\/strong><\/u><\/a>, nh\u00e0 nghi\u00ean c\u1ee9u h\u00f3a th\u1ef1c ph\u1ea9m, \u0111\u00e3 l\u00e0m s\u00e1ng t\u1ecf c\u01a1 ch\u1ebf v\u1eadt l\u00fd n\u00e0y: gi\u1ea5y l\u1ecdc ng\u0103n ch\u1eb7n c\u00e1c h\u1ea1t m\u1ecbn l\u1ecdt v\u00e0o d\u1ecbch chi\u1ebft v\u00e0 gi\u1eef l\u1ea1i trung b\u00ecnh 87,6% cafestol, t\u00f9y thu\u1ed9c v\u00e0o \u0111\u1ed9 x\u1ed1p c\u1ee7a gi\u1ea5y v\u00e0 c\u1ee1 xay c\u1ee7a b\u1ed9t c\u00e0 ph\u00ea. C\u1ee1 xay c\u00e0ng th\u00f4 v\u00e0 gi\u1ea5y l\u1ecdc c\u00e0ng d\u00e0y d\u1eb7n th\u00ec kh\u1ea3 n\u0103ng lo\u1ea1i b\u1ecf diterpene c\u00e0ng tri\u1ec7t \u0111\u1ec3.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">T\u00e1c \u0111\u1ed9ng tim m\u1ea1ch c\u1ee7a \u0111i\u1ec1u n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn v\u1eefng ch\u1eafc trong khoa h\u1ecdc lipid: u\u1ed1ng c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc th\u01b0\u1eddng xuy\u00ean l\u00e0m t\u0103ng r\u00f5 r\u1ec7t n\u1ed3ng \u0111\u1ed9 cholesterol LDL trong m\u00e1u. \u0110\u00e2y kh\u00f4ng ph\u1ea3i m\u1ed1i lo tr\u00ean gi\u1ea5y \u2014 n\u00f3 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh qua nhi\u1ec1u nghi\u00ean c\u1ee9u can thi\u1ec7p l\u00e2m s\u00e0ng c\u00f3 \u0111\u1ed1i ch\u1ee9ng v\u00e0 \u0111\u1ee7 s\u1ee9c n\u1eb7ng \u0111\u1ec3 \u1ea3nh h\u01b0\u1edfng t\u1edbi khuy\u1ebfn c\u00e1o dinh d\u01b0\u1ee1ng t\u1ea1i nhi\u1ec1u qu\u1ed1c gia. Theo nhi\u1ec1u ph\u00e2n t\u00edch, cafestol l\u00e0 h\u1ee3p ch\u1ea5t l\u00e0m t\u0103ng cholesterol trong ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng m\u1ea1nh nh\u1ea5t t\u1eebng \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong c\u00e1c th\u1ef1c ph\u1ea9m th\u00f4ng th\u01b0\u1eddng.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0110\u1eb7c t\u00ednh \u1ee9c ch\u1ebf t\u1ebf b\u00e0o ung th\u01b0 c\u1ee7a cafestol v\u00e0 kahweol trong ph\u00f2ng th\u00ed nghi\u1ec7m l\u00e0 c\u00f3 th\u1eadt, nh\u01b0ng c\u1ea7n \u0111\u01b0\u1ee3c \u0111\u1eb7t trong b\u1ed1i c\u1ea3nh l\u00e2m s\u00e0ng: khi u\u1ed1ng c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc, t\u00e1c \u0111\u1ed9ng t\u0103ng m\u1ee1 m\u00e1u LDL di\u1ec5n ra song song v\u1edbi b\u1ea5t k\u1ef3 t\u00edn hi\u1ec7u b\u1ea3o v\u1ec7 ti\u1ec1m n\u0103ng n\u00e0o. Hi\u1ec7n ch\u01b0a c\u00f3 b\u1eb1ng ch\u1ee9ng thuy\u1ebft ph\u1ee5c tr\u00ean ng\u01b0\u1eddi cho th\u1ea5y l\u1ee3i \u00edch ch\u1ed1ng ung th\u01b0 \u1edf li\u1ec1u l\u01b0\u1ee3ng \u0103n u\u1ed1ng th\u00f4ng th\u01b0\u1eddng c\u00f3 th\u1ec3 b\u00f9 \u0111\u1eafp \u0111\u01b0\u1ee3c r\u1ee7i ro x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch do LDL t\u0103ng cao k\u00e9o d\u00e0i.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[Xem video ph\u00e2n t\u00edch t\u1eeb NutritionFacts.org \u0111\u1ec3 hi\u1ec3u r\u00f5 nh\u1eefng b\u1eb1ng ch\u1ee9ng l\u00e2m s\u00e0ng v\u1ec1 m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa c\u00e0 ph\u00ea v\u00e0 cholesterol:]<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"Does Coffee Affect Cholesterol?\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/uqKf9UvPDuA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u0110\u00e1nh \u0110\u1ed5i Diterpene: T\u1ea1i Sao G\u00e1n M\u00e1c &#8220;B\u1ea3o V\u1ec7 Tim M\u1ea1ch&#8221; L\u00e0 Sai B\u1ea3n Ch\u1ea5t<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">T\u00e1c \u0111\u1ed9ng t\u0103ng LDL c\u1ee7a diterpene l\u00e0 m\u1ed9t trong nh\u1eefng th\u00f4ng tin quan tr\u1ecdng nh\u1ea5t th\u01b0\u1eddng b\u1ecb b\u1ecf qua \u2014 v\u00e0 c\u00e1ch n\u00f3 b\u1ecb truy\u1ec1n th\u00f4ng sai l\u1ec7ch c\u00e0ng khi\u1ebfn v\u1ea5n \u0111\u1ec1 th\u00eam tr\u1ea7m tr\u1ecdng. M\u1ed9t s\u1ed1 trang tin g\u00e1n cho cafestol v\u00e0 kahweol c\u00e1i m\u00e1c &#8220;b\u1ea3o v\u1ec7 tim m\u1ea1ch&#8221; ch\u1ec9 d\u1ef1a tr\u00ean d\u1eef li\u1ec7u nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o, m\u00e0 kh\u00f4ng h\u1ec1 gi\u1ea3i th\u00edch r\u1eb1ng nh\u1eadn \u0111\u1ecbnh n\u00e0y ch\u1ec9 c\u00f3 ngh\u0129a n\u1ebfu c\u00e1c h\u1ee3p ch\u1ea5t \u0111\u00f3 \u0111\u00e3 b\u1ecb lo\u1ea1i b\u1ecf tr\u01b0\u1edbc khi b\u1ea1n u\u1ed1ng.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Logic c\u1ee7a v\u1ea5n \u0111\u1ec1 r\u1ea5t r\u00f5 r\u00e0ng: cafestol v\u00e0 kahweol cho th\u1ea5y t\u00edn hi\u1ec7u ch\u1ed1ng ung th\u01b0 trong \u1ed1ng nghi\u1ec7m. Nh\u01b0ng m\u00e0ng l\u1ecdc gi\u1ea5y \u0111\u00e3 lo\u1ea1i b\u1ecf h\u01a1n 90% l\u01b0\u1ee3ng ch\u1ea5t n\u00e0y. V\u00ec v\u1eady, n\u1ebfu b\u1ea1n u\u1ed1ng c\u00e0 ph\u00ea pha qua gi\u1ea5y l\u1ecdc \u2014 ph\u01b0\u01a1ng ph\u00e1p g\u1eafn li\u1ec1n v\u1edbi c\u00e1c l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe trong nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec5 \u2014 b\u1ea1n th\u1ef1c ch\u1ea5t kh\u00f4ng h\u1ec1 n\u1ea1p l\u01b0\u1ee3ng diterpene \u0111\u00e1ng k\u1ec3 n\u00e0o. Chi\u1ebfc m\u00e1c &#8220;b\u1ea3o v\u1ec7 tim m\u1ea1ch&#8221; \u0111ang b\u1ecb g\u00e1n nh\u1ea7m cho c\u00e1c h\u1ee3p ch\u1ea5t v\u1ed1n v\u1eafng m\u1eb7t trong ly c\u00e0 ph\u00ea c\u1ee7a nh\u1eefng ng\u01b0\u1eddi quan t\u00e2m \u0111\u1ebfn s\u1ee9c kh\u1ecfe.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trong c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc, n\u01a1i cafestol v\u00e0 kahweol hi\u1ec7n di\u1ec7n v\u1edbi h\u00e0m l\u01b0\u1ee3ng d\u01b0\u1ee3c l\u00fd th\u1ef1c th\u1ee5, t\u00e1c \u0111\u1ed9ng t\u0103ng LDL g\u00e2y h\u1ea1i cho h\u1ec7 tim m\u1ea1ch l\u00e0 bi\u1ec3u hi\u1ec7n sinh h\u1ecdc v\u01b0\u1ee3t tr\u1ed9i tr\u00ean c\u01a1 th\u1ec3 ng\u01b0\u1eddi \u2014 ch\u1ee9 kh\u00f4ng ph\u1ea3i c\u00e1c l\u1ee3i \u00edch ch\u1ed1ng ung th\u01b0 l\u00fd thuy\u1ebft ch\u01b0a t\u1eebng \u0111\u01b0\u1ee3c ch\u1ee9ng minh \u1edf li\u1ec1u \u0103n u\u1ed1ng. Khuy\u00ean d\u00f9ng c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc ch\u1ec9 v\u00ec l\u01b0\u1ee3ng diterpene l\u00e0 m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn b\u1eb1ng ch\u1ee9ng thi\u1ebfu th\u1ea5u \u0111\u00e1o, th\u1eadm ch\u00ed c\u00f3 th\u1ec3 g\u00e2y nguy hi\u1ec3m cho nh\u1eefng ng\u01b0\u1eddi \u0111ang c\u00f3 m\u1ee1 m\u00e1u cao.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u1eddi khuy\u00ean th\u1ef1c ti\u1ec5n r\u1ea5t r\u00f5 r\u00e0ng: n\u1ebfu b\u1ea1n c\u00f3 ch\u1ec9 s\u1ed1 cholesterol cao, ti\u1ec1n s\u1eed gia \u0111\u00ecnh m\u1eafc b\u1ec7nh tim m\u1ea1ch ho\u1eb7c c\u00f3 nguy c\u01a1 chuy\u1ec3n h\u00f3a, c\u00e0 ph\u00ea l\u1ecdc qua gi\u1ea5y lu\u00f4n l\u00e0 l\u1ef1a ch\u1ecdn \u01b0u ti\u00ean m\u1eb7c \u0111\u1ecbnh. Nh\u1eefng l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe l\u00e2u d\u00e0i trong c\u00e1c t\u00e0i li\u1ec7u khoa h\u1ecdc ch\u1ee7 y\u1ebfu \u0111\u1ebfn t\u1eeb c\u00e1c qu\u1ea7n th\u1ec3 u\u1ed1ng c\u00e0 ph\u00ea l\u1ecdc gi\u1ea5y. C\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc kh\u00f4ng gi\u00fap b\u1ea1n b\u1ea3o v\u1ec7 c\u01a1 th\u1ec3 t\u1ed1t h\u01a1n \u2014 m\u00e0 ch\u1ec9 l\u00e0m t\u0103ng th\u00eam r\u1ee7i ro tim m\u1ea1ch m\u00e0 c\u00e1c ho\u1ea1t ch\u1ea5t kh\u00e1c kh\u00f3 l\u00f2ng b\u00f9 \u0111\u1eafp.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">T\u00ecm \u0110\u1ecbnh M\u1ee9c L\u00fd T\u01b0\u1edfng: B\u1ea1n N\u00ean U\u1ed1ng Bao Nhi\u00eau C\u00e0 Ph\u00ea M\u1ed7i Ng\u00e0y?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0110\u1ecbnh l\u01b0\u1ee3ng c\u00e0 ph\u00ea t\u1ed1i \u01b0u kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t con s\u1ed1 c\u1ed1 \u0111\u1ecbnh \u2014 n\u00f3 l\u00e0 m\u1ed9t kho\u1ea3ng bi\u1ebfn thi\u00ean t\u00f9y thu\u1ed9c v\u00e0o gen di truy\u1ec1n, t\u00ecnh tr\u1ea1ng m\u1ee1 m\u00e1u, h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 m\u1ee5c ti\u00eau s\u1ee9c kh\u1ecfe c\u1ee7a ri\u00eang b\u1ea1n. D\u1eabu v\u1eady, c\u00e1c d\u1eef li\u1ec7u khoa h\u1ecdc \u0111\u1ec1u h\u1ed9i t\u1ee5 v\u1ec1 m\u1ed9t khung \u0111\u1ecbnh l\u01b0\u1ee3ng th\u1ef1c ti\u1ec5n v\u00e0 c\u1ee5 th\u1ec3.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ph\u00e1t hi\u1ec7n r\u00f5 n\u00e9t nh\u1ea5t t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec5 l\u00e0 m\u1ee9c 2\u20133 t\u00e1ch c\u00e0 ph\u00ea l\u1ecdc gi\u1ea5y m\u1ed7i ng\u00e0y (t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 480\u2013720ml) mang l\u1ea1i kh\u1ea3 n\u0103ng ph\u00f2ng ch\u1ed1ng c\u00e1c b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh v\u00e0 chuy\u1ec3n h\u00f3a m\u1ed9t c\u00e1ch nh\u1ea5t qu\u00e1n nh\u1ea5t. D\u01b0\u1edbi m\u1ee9c n\u00e0y, hi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7 ch\u01b0a th\u1ef1c s\u1ef1 r\u00f5 r\u1ec7t; v\u01b0\u1ee3t qu\u00e1 4\u20135 t\u00e1ch m\u1ed7i ng\u00e0y, l\u1ee3i \u00edch b\u1eaft \u0111\u1ea7u \u0111i ngang trong khi r\u1ee7i ro k\u00edch \u1ee9ng \u2014 b\u1ed3n ch\u1ed3n, tim \u0111\u1eadp nhanh, r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7 \u2014 l\u1ea1i t\u0103ng cao.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.mdpi.com\/journal\/nutrients\" rel=\"nofollow noopener\" target=\"_blank\"><u><strong>GS. Adriana Farah<\/strong><\/u><\/a> \u0111\u00e3 l\u01b0\u1ee3ng h\u00f3a h\u00e0m l\u01b0\u1ee3ng ho\u1ea1t ch\u1ea5t c\u1ee7a \u0111\u1ecbnh m\u1ee9c n\u00e0y: v\u1edbi \u01b0\u1edbc t\u00ednh kho\u1ea3ng 100 mg axit chlorogenic trong m\u1ed7i kh\u1ea9u ph\u1ea7n 100ml c\u00e0 ph\u00ea l\u1ecdc, u\u1ed1ng t\u1eeb 1 \u0111\u1ebfn 3 t\u00e1ch m\u1ed7i ng\u00e0y mang l\u1ea1i 100\u2013300 mg CGA \u2014 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng m\u1ee9c n\u1ed3ng \u0111\u1ed9 th\u1ea5p nh\u1ea5t trong c\u00e1c nghi\u00ean c\u1ee9u c\u01a1 ch\u1ebf t\u1ebf b\u00e0o. \u0110\u00e2y ch\u00ednh l\u00e0 c\u1ea7u n\u1ed1i g\u1eafn k\u1ebft d\u1eef li\u1ec7u ph\u00f2ng th\u00ed nghi\u1ec7m FGF21 v\u1edbi c\u00e1c kh\u1ea3o s\u00e1t d\u1ecbch t\u1ec5 tr\u00ean di\u1ec7n r\u1ed9ng. Th\u00f3i quen duy tr\u00ec 2 t\u00e1ch c\u00e0 ph\u00ea l\u1ecdc m\u1ed7i ng\u00e0y \u0111\u1ea3m b\u1ea3o mang l\u1ea1i li\u1ec1u l\u01b0\u1ee3ng CGA c\u00f3 \u00fd ngh\u0129a sinh h\u1ecdc th\u1ef1c t\u1ebf.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0110\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi c\u00f3 m\u1ee1 m\u00e1u LDL cao ho\u1eb7c c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh tim m\u1ea1ch gia \u0111\u00ecnh, khuy\u1ebfn ngh\u1ecb s\u1ebd \u0111i\u1ec1u ch\u1ec9nh: duy tr\u00ec 1\u20132 t\u00e1ch m\u1ed7i ng\u00e0y v\u00e0 b\u1eaft bu\u1ed9c d\u00f9ng ph\u01b0\u01a1ng ph\u00e1p l\u1ecdc gi\u1ea5y. \u0110i\u1ec1u n\u00e0y gi\u00fap b\u1ea1n thu tr\u1ecdn l\u1ee3i \u00edch chuy\u1ec3n h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 th\u1ea7n kinh m\u00e0 kh\u00f4ng ph\u1ea3i \u0111\u1ed1i m\u1eb7t v\u1edbi nguy c\u01a1 t\u0103ng cholesterol t\u1eeb diterpene.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Khi ti\u00eau th\u1ee5 l\u01b0\u1ee3ng l\u1edbn \u2014 tr\u00ean 4\u20135 t\u00e1ch m\u1ed7i ng\u00e0y \u2014 c\u00e1n c\u00e2n l\u1ee3i \u00edch v\u00e0 nguy c\u01a1 b\u1eaft \u0111\u1ea7u \u0111\u1ea3o chi\u1ec1u. T\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 kh\u00f4ng t\u0103ng th\u00eam, trong khi g\u00e1nh n\u1eb7ng k\u00edch th\u00edch t\u1eeb caffeine t\u00edch t\u1ee5: l\u00e0m gi\u00e1n \u0111o\u1ea1n c\u1ea5u tr\u00fac gi\u1ea5c ng\u1ee7 s\u00e2u, t\u0103ng cortisol v\u00e0 g\u00e2y \u00e1p l\u1ef1c l\u00ean tim m\u1ea1ch. Y\u1ebfu t\u1ed1 chuy\u1ec3n h\u00f3a caffeine qua gen CYP1A2 c\u0169ng \u0111\u00f3ng vai tr\u00f2 quy\u1ebft \u0111\u1ecbnh: ng\u01b0\u1eddi chuy\u1ec3n h\u00f3a ch\u1eadm s\u1ebd \u0111\u1ed1i m\u1eb7t v\u1edbi nhi\u1ec1u r\u1ee7i ro tim m\u1ea1ch h\u01a1n ng\u01b0\u1eddi chuy\u1ec3n h\u00f3a nhanh khi c\u00f9ng u\u1ed1ng m\u1ed9t l\u01b0\u1ee3ng c\u00e0 ph\u00ea l\u1edbn.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">M\u1ed9t \u0111i\u1ec3m quy chu\u1ea9n c\u1ea7n nh\u1edb: m\u1ed9t &#8220;t\u00e1ch&#8221; (cup) trong y v\u0103n t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi 240ml (8 oz), kh\u00f4ng ph\u1ea3i nh\u1eefng ly kh\u1ed5ng l\u1ed3 480ml (16 oz) \u1edf qu\u00e1n c\u00e0 ph\u00ea. H\u00e0m l\u01b0\u1ee3ng ho\u1ea1t ch\u1ea5t c\u0169ng dao \u0111\u1ed9ng l\u1edbn theo gi\u1ed1ng h\u1ea1t, \u0111\u1ed9 rang v\u00e0 t\u1ef7 l\u1ec7 pha, do \u0111\u00f3 c\u00e1c con s\u1ed1 n\u00e0y \u0111\u00f3ng vai tr\u00f2 nh\u01b0 kim ch\u1ec9 nam tham kh\u1ea3o h\u1eefu \u00edch.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">B\u1ea3ng d\u01b0\u1edbi \u0111\u00e2y t\u1ed5ng h\u1ee3p h\u00e0m l\u01b0\u1ee3ng c\u00e1c ho\u1ea1t ch\u1ea5t sinh h\u1ecdc qua c\u00e1c c\u1ea5p \u0111\u1ed9 rang v\u00e0 ph\u01b0\u01a1ng ph\u00e1p pha ch\u1ebf d\u1ef1a tr\u00ean c\u00e1c c\u01a1 s\u1edf d\u1eef li\u1ec7u ph\u00e2n t\u00edch chu\u1ea9n:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>H\u1ee3p ch\u1ea5t<\/th><th>Rang Nh\u1ea1t, L\u1ecdc Gi\u1ea5y<\/th><th>Rang \u0110\u1eadm, L\u1ecdc Gi\u1ea5y<\/th><th>Espresso (m\u1ed7i shot)<\/th><th>French Press (B\u00ecnh \u00c9p) (B\u00ecnh \u00c9p)<\/th><\/tr><\/thead><tbody><tr><td>Axit chlorogenic<\/td><td>100\u2013200 mg<\/td><td>50\u2013100 mg<\/td><td>40\u201390 mg<\/td><td>80\u2013160 mg<\/td><\/tr><tr><td>Caffeine<\/td><td>80\u2013120 mg<\/td><td>80\u2013115 mg<\/td><td>60\u201375 mg<\/td><td>80\u2013110 mg<\/td><\/tr><tr><td>Trigonelline<\/td><td>25\u201340 mg<\/td><td>10\u201320 mg<\/td><td>20\u201335 mg<\/td><td>20\u201335 mg<\/td><\/tr><tr><td>Cafestol + Kahweol<\/td><td>&lt;2 mg (\u0111\u00e3 l\u1ecdc s\u1ea1ch)<\/td><td>&lt;2 mg (\u0111\u00e3 l\u1ecdc s\u1ea1ch)<\/td><td>2\u20134 mg<\/td><td>4\u20138 mg m\u1ed7i t\u00e1ch<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">B\u1ea3ng s\u1ed1 li\u1ec7u l\u00e0m n\u1ed5i b\u1eadt nh\u1eefng \u0111i\u1ec1u m\u00e0 c\u00e2u ch\u1eef d\u1ec5 che khu\u1ea5t. C\u00e0 ph\u00ea rang nh\u1ea1t l\u1ecdc gi\u1ea5y l\u00e0 qu\u00e1n qu\u00e2n v\u1ec1 h\u00e0m l\u01b0\u1ee3ng CGA \u2014 l\u1ef1a ch\u1ecdn h\u00e0ng \u0111\u1ea7u n\u1ebfu b\u1ea1n \u01b0u ti\u00ean chuy\u1ec3n h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 gan. L\u01b0\u1ee3ng caffeine t\u01b0\u01a1ng \u0111\u1ed1i \u1ed5n \u0111\u1ecbnh gi\u1eefa c\u00e1c ki\u1ec3u rang, ch\u1ee9ng minh r\u1eb1ng ch\u1ec9nh \u0111\u1ed9 rang kh\u00f4ng ph\u1ea3i l\u00e0 c\u00e1ch chu\u1ea9n \u0111\u1ec3 ki\u1ec3m so\u00e1t l\u01b0\u1ee3ng ch\u1ea5t k\u00edch th\u00edch. C\u1ed9t diterpene cho th\u1ea5y l\u00fd do b\u00ecnh French press t\u1ea1o ra b\u1ee9c tranh s\u1ee9c kh\u1ecfe ho\u00e0n to\u00e0n kh\u00e1c bi\u1ec7t so v\u1edbi pour-over, d\u00f9 d\u00f9ng c\u00f9ng m\u1ed9t lo\u1ea1i h\u1ea1t.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">S\u1ee3i d\u00e2y xuy\u00ean su\u1ed1t t\u1eeb d\u1eef li\u1ec7u t\u1ebf b\u00e0o \u0111\u1ebfn th\u1ef1c ti\u1ec5n \u0111\u1eddi s\u1ed1ng \u0111\u00e3 \u0111\u01b0\u1ee3c k\u1ebft n\u1ed1i: m\u1ee9c k\u00edch ho\u1ea1t FGF21 v\u00e0 Nrf2 trong t\u1ebf b\u00e0o gan \u1edf n\u1ed3ng \u0111\u1ed9 50 \u00b5mol\/L axit chlorogenic ho\u00e0n to\u00e0n t\u01b0\u01a1ng \u1ee9ng v\u1edbi m\u1ee9c m\u00e0 m\u1ed9t ng\u01b0\u1eddi u\u1ed1ng c\u00e0 ph\u00ea l\u1ecdc gi\u1ea5y \u0111i\u1ec1u \u0111\u1ed9 c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c. D\u00f9 ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 c\u01a1 th\u1ec3 s\u1ed1ng lu\u00f4n c\u00f3 kho\u1ea3ng c\u00e1ch nh\u1ea5t \u0111\u1ecbnh, s\u1ef1 \u0111\u1ed3ng quy gi\u1eefa c\u01a1 ch\u1ebf ph\u00e2n t\u1eed v\u00e0 d\u1ecbch t\u1ec5 h\u1ecdc d\u00e2n s\u1ed1 cho th\u1ea5y ch\u00fang ta \u0111ang \u0111i \u0111\u00fang h\u01b0\u1edbng v\u1edbi nh\u1eefng li\u1ec1u l\u01b0\u1ee3ng ho\u00e0n to\u00e0n kh\u1ea3 thi.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Key Takeaways on Coffee Bioactive H\u1ee3p ch\u1ea5t Groups<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>C\u00e0 ph\u00ea ch\u1ee9a h\u01a1n 1.000 h\u1ee3p ch\u1ea5t ho\u1ea1t t\u00ednh sinh h\u1ecdc; l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe b\u1eaft ngu\u1ed3n t\u1eeb to\u00e0n b\u1ed9 ma tr\u1eadn t\u1ef1 nhi\u00ean, kh\u00f4ng ri\u00eang g\u00ec caffeine.<\/li>\n\n\n\n<li>Axit chlorogenic are the dominant polyphenols and activate Nrf2 and AMPK pathways in liver cells, reducing fat accumulation and improving glucose metabolism.<\/li>\n\n\n\n<li>Rang nh\u1ea1t b\u1ea3o t\u1ed3n t\u1ed1i \u0111a axit chlorogenic; rang \u0111\u1eadm \u0111\u00e1nh \u0111\u1ed5i CGA \u0111\u1ec3 l\u1ea5y melanoidin v\u00e0 b\u1ed5 sung th\u00eam niacin \u2014 c\u1ea3 hai \u0111\u1ec1u c\u00f3 gi\u00e1 tr\u1ecb ri\u00eang.<\/li>\n\n\n\n<li>Gi\u1ea5y l\u1ecdc lo\u1ea1i b\u1ecf h\u01a1n 90% cafestol v\u00e0 kahweol, gi\u00fap c\u00e0 ph\u00ea l\u1ecdc an to\u00e0n cho tim m\u1ea1ch; c\u00e0 ph\u00ea kh\u00f4ng l\u1ecdc l\u1ea1i ch\u1ee9a l\u01b0\u1ee3ng diterpene l\u00e0m t\u0103ng cholesterol LDL \u0111\u00e1ng k\u1ec3.<\/li>\n\n\n\n<li>V\u1edbi ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh kh\u1ecfe m\u1ea1nh, 2\u20133 t\u00e1ch c\u00e0 ph\u00ea l\u1ecdc gi\u1ea5y m\u1ed7i ng\u00e0y (480\u2013720ml) l\u00e0 \u0111\u1ecbnh m\u1ee9c l\u00fd t\u01b0\u1edfng nh\u1ea5t \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 b\u1ec7nh chuy\u1ec3n h\u00f3a v\u00e0 tho\u00e1i h\u00f3a th\u1ea7n kinh.<\/li>\n\n\n\n<li>Ng\u01b0\u1eddi c\u00f3 cholesterol LDL cao ho\u1eb7c c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh tim m\u1ea1ch n\u00ean gi\u1edbi h\u1ea1n \u1edf m\u1ee9c 1\u20132 t\u00e1ch m\u1ed7i ng\u00e0y v\u00e0 b\u1eaft bu\u1ed9c d\u00f9ng ph\u01b0\u01a1ng ph\u00e1p l\u1ecdc qua gi\u1ea5y.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Frequently Asked Questions About Coffee Bioactive H\u1ee3p ch\u1ea5t Groups<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">C\u00e0 ph\u00ea decaf c\u00f3 mang l\u1ea1i l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe t\u01b0\u01a1ng \u0111\u01b0\u01a1ng c\u00e0 ph\u00ea th\u01b0\u1eddng kh\u00f4ng?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e0 ph\u00ea decaf v\u1eabn gi\u1eef tr\u1ecdn h\u1ea7u h\u1ebft axit chlorogenic, melanoidin v\u00e0 trigonelline d\u00f9 \u0111\u00e3 lo\u1ea1i b\u1ecf ph\u1ea7n l\u1edbn caffeine. Do \u0111\u00f3, c\u00e1c l\u1ee3i \u00edch v\u1ec1 chuy\u1ec3n h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 gan h\u1ea7u nh\u01b0 \u0111\u01b0\u1ee3c b\u1ea3o to\u00e0n nguy\u00ean v\u1eb9n, trong khi t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh (v\u1ed1n ph\u1ee5 thu\u1ed9c nhi\u1ec1u v\u00e0o caffeine) c\u00f3 ph\u1ea7n nh\u1eb9 h\u01a1n. N\u1ebfu b\u1ea1n nh\u1ea1y c\u1ea3m v\u1edbi ch\u1ea5t k\u00edch th\u00edch, decaf l\u00e0 s\u1ef1 l\u1ef1a ch\u1ecdn tuy\u1ec7t v\u1eddi m\u00e0 kh\u00f4ng ph\u1ea3i hy sinh \u0111a s\u1ed1 l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe c\u1ee7a c\u00e0 ph\u00ea.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Th\u00eam s\u1eefa ho\u1eb7c kem b\u00e9o c\u00f3 ph\u00e1 h\u1ee7y c\u00e1c h\u1ee3p ch\u1ea5t ho\u1ea1t t\u00ednh sinh h\u1ecdc kh\u00f4ng?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Protein trong s\u1eefa c\u00f3 th\u1ec3 li\u00ean k\u1ebft t\u1ea1m th\u1eddi v\u1edbi c\u00e1c polyphenol nh\u01b0 axit chlorogenic v\u00e0 l\u00e0m ch\u1eadm kh\u1ea3 n\u0103ng h\u1ea5p thu t\u1ea1i ru\u1ed9t, nh\u01b0ng c\u00e1c b\u1eb1ng ch\u1ee9ng v\u1ec1 vi\u1ec7c \u0111i\u1ec1u n\u00e0y l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 s\u1ee9c kh\u1ecfe l\u00e2u d\u00e0i v\u1eabn ch\u01b0a \u0111\u1ed3ng nh\u1ea5t \u2014 nhi\u1ec1u nghi\u00ean c\u1ee9u cho th\u1ea5y c\u00e1c polyphenol n\u00e0y v\u1eabn \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng v\u00e0 h\u1ea5p thu t\u1ed1t trong qu\u00e1 tr\u00ecnh ti\u00eau h\u00f3a sau \u0111\u00f3. H\u00e3y y\u00ean t\u00e2m th\u01b0\u1edfng th\u1ee9c ly c\u00e0 ph\u00ea s\u1eefa n\u1ebfu \u0111\u00f3 l\u00e0 s\u1edf th\u00edch c\u1ee7a b\u1ea1n.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">C\u00e0 ph\u00ea \u1ee7 l\u1ea1nh (Cold Brew) c\u00f3 gi\u1eef \u0111\u01b0\u1ee3c nhi\u1ec1u ho\u1ea1t ch\u1ea5t h\u01a1n c\u00e0 ph\u00ea pha n\u00f3ng?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Cold brew th\u01b0\u1eddng chi\u1ebft xu\u1ea5t \u0111\u01b0\u1ee3c \u00edt axit chlorogenic h\u01a1n c\u00e1c c\u00e1ch pha n\u00f3ng v\u00ec \u0111\u1ed9 h\u00f2a tan c\u1ee7a CGA t\u0103ng theo nhi\u1ec7t \u0111\u1ed9 n\u01b0\u1edbc, do \u0111\u00f3 l\u01b0\u1ee3ng polyphenol thu \u0111\u01b0\u1ee3c m\u1ed7i ly th\u01b0\u1eddng th\u1ea5p h\u01a1n d\u00f9 th\u1eddi gian \u1ee7 l\u00e2u h\u01a1n. \u0110i\u1ec3m c\u1ed9ng c\u1ee7a cold brew l\u00e0 \u0111\u1ed9 chua th\u1ea5p h\u01a1n, d\u1ec5 ch\u1ecbu cho d\u1ea1 d\u00e0y \u2014 nh\u01b0ng x\u00e9t ri\u00eang v\u1ec1 n\u1ed3ng \u0111\u1ed9 ho\u1ea1t ch\u1ea5t CGA, c\u00e0 ph\u00ea pha n\u00f3ng l\u1ecdc gi\u1ea5y v\u1eabn nh\u1ec9nh h\u01a1n.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">U\u1ed1ng vi\u00ean th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng chi\u1ebft xu\u1ea5t c\u00e0 ph\u00ea c\u00f3 mang l\u1ea1i t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 gan t\u01b0\u01a1ng t\u1ef1 kh\u00f4ng?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Chi\u1ebft xu\u1ea5t c\u00e0 ph\u00ea xanh c\u00f3 th\u1ec3 cung c\u1ea5p axit chlorogenic, nh\u01b0ng hi\u1ec7u \u1ee9ng ma tr\u1eadn t\u1ef1 nhi\u00ean \u2014 s\u1ef1 t\u01b0\u01a1ng h\u1ed7 gi\u1eefa CGA, melanoidin, trigonelline v\u00e0 c\u00e1c vi ch\u1ea5t kh\u00e1c \u2014 ho\u00e0n to\u00e0n bi\u1ebfn m\u1ea5t trong c\u00e1c vi\u00ean u\u1ed1ng \u0111\u01a1n l\u1ebb. C\u00e1c d\u1eef li\u1ec7u b\u1ea3o v\u1ec7 gan \u0111\u01b0\u1ee3c x\u00e2y d\u1ef1ng d\u1ef1a tr\u00ean th\u00f3i quen u\u1ed1ng c\u00e0 ph\u00ea nguy\u00ean b\u1ea3n, do \u0111\u00f3 vi\u00ean u\u1ed1ng b\u1ed5 sung kh\u00f4ng th\u1ec3 thay th\u1ebf ho\u00e0n to\u00e0n m\u1ed9t t\u00e1ch c\u00e0 ph\u00ea th\u1ef1c th\u1ee5.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">C\u00e0 ph\u00ea h\u00f2a tan c\u00f3 ph\u1ea3i l\u00e0 ngu\u1ed3n cung c\u1ea5p ho\u1ea1t ch\u1ea5t sinh h\u1ecdc t\u1ed1t kh\u00f4ng?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e0 ph\u00ea h\u00f2a tan v\u1eabn gi\u1eef \u0111\u01b0\u1ee3c l\u01b0\u1ee3ng axit chlorogenic \u0111\u00e1ng k\u1ec3 \u2014 th\u01b0\u1eddng dao \u0111\u1ed9ng t\u1eeb 50\u2013150 mg m\u1ed7i t\u00e1ch \u2014 v\u00ec n\u00f3 \u0111\u01b0\u1ee3c ch\u1ebf bi\u1ebfn t\u1eeb c\u00e0 ph\u00ea pha nguy\u00ean ch\u1ea5t s\u1ea5y phun ho\u1eb7c s\u1ea5y l\u1ea1nh. \u0110\u00e2y v\u1eabn l\u00e0 ngu\u1ed3n ho\u1ea1t ch\u1ea5t sinh h\u1ecdc h\u1ee3p l\u1ec7, d\u00f9 h\u00e0m l\u01b0\u1ee3ng CGA th\u01b0\u1eddng th\u1ea5p h\u01a1n c\u00e0 ph\u00ea pha m\u1edbi v\u00e0 c\u00f3 th\u1ec3 ch\u1ee9a nhi\u1ec1u acrylamide h\u01a1n do ph\u1ea3i qua nhi\u1ec1u c\u00f4ng \u0111o\u1ea1n x\u1eed l\u00fd nhi\u1ec7t.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">H\u00e0m l\u01b0\u1ee3ng ho\u1ea1t ch\u1ea5t sinh h\u1ecdc c\u00f3 thay \u0111\u1ed5i theo v\u00f9ng tr\u1ed3ng hay gi\u1ed1ng h\u1ea1t kh\u00f4ng?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00f3, v\u00e0 kh\u00e1c bi\u1ec7t r\u1ea5t l\u1edbn. H\u1ea1t Robusta ch\u1ee9a h\u00e0m l\u01b0\u1ee3ng axit chlorogenic cao g\u1ea7n g\u1ea5p \u0111\u00f4i so v\u1edbi Arabica. \u0110\u1ed9 cao v\u00f9ng tr\u1ed3ng, th\u1ed5 nh\u01b0\u1ee1ng v\u00e0 ph\u01b0\u01a1ng ph\u00e1p s\u01a1 ch\u1ebf \u0111\u1ec1u t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn l\u01b0\u1ee3ng CGA trong h\u1ea1t c\u00e0 ph\u00ea nh\u00e2n. \u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a hai t\u00e1ch c\u00e0 ph\u00ea rang nh\u1ea1t t\u1eeb hai v\u00f9ng \u0111\u1ea5t kh\u00e1c nhau c\u00f3 th\u1ec3 mang l\u1ea1i nh\u1eefng h\u1ed3 s\u01a1 polyphenol ho\u00e0n to\u00e0n kh\u00e1c bi\u1ec7t.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Ng\u01b0\u1eddi m\u1eafc ti\u1ec3u \u0111\u01b0\u1eddng type 2 c\u00f3 n\u00ean u\u1ed1ng c\u00e0 ph\u00ea \u0111\u1ec3 c\u1ea3i thi\u1ec7n chuy\u1ec3n h\u00f3a kh\u00f4ng?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">D\u1eef li\u1ec7u d\u1ecbch t\u1ec5 h\u1ecdc v\u1ec1 ph\u00f2ng ng\u1eeba ti\u1ec3u \u0111\u01b0\u1eddng l\u00e0 v\u00f4 c\u00f9ng nh\u1ea5t qu\u00e1n \u2014 c\u1ea3 c\u00e0 ph\u00ea th\u01b0\u1eddng l\u1eabn decaf \u0111\u1ec1u gi\u00fap gi\u1ea3m nguy c\u01a1 m\u1eafc b\u1ec7nh. Tuy nhi\u00ean, n\u1ebfu b\u1ea1n \u0111\u00e3 m\u1eafc b\u1ec7nh v\u00e0 \u0111ang d\u00f9ng thu\u1ed1c ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft, caffeine c\u00f3 th\u1ec3 g\u00e2y bi\u1ebfn \u0111\u1ed9ng \u0111\u01b0\u1eddng huy\u1ebft t\u1ee9c th\u1eddi trong ng\u1eafn h\u1ea1n. L\u1ee3i \u00edch chuy\u1ec3n h\u00f3a d\u00e0i h\u1ea1n l\u00e0 r\u1ea5t t\u00edch c\u1ef1c, nh\u01b0ng b\u1ea1n n\u00ean tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh l\u01b0\u1ee3ng caffeine ph\u00f9 h\u1ee3p.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Kh\u1ea3 n\u0103ng ch\u1ed1ng oxy h\u00f3a c\u1ee7a c\u00e0 ph\u00ea c\u00f3 b\u1ecb m\u1ea5t \u0111i khi \u0111\u1ec3 trong b\u00ecnh gi\u1eef nhi\u1ec7t nhi\u1ec1u gi\u1edd?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Axit chlorogenic are relatively stable at room temperature over several hours, but the antioxidant capacity of brewed coffee does decline with prolonged exposure to heat and oxygen. Keeping coffee on a heated plate or in a hot thermos for more than a couple of hours measurably degrades polyphenol content &#8211; brewing fresh, or storing in a sealed insulated container at room temperature, preserves more bioactive activity.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">T\u00e0i Li\u1ec7u Tham Kh\u1ea3o<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Coffee as a Biosynergistic System &#8211; Frontiers in Nutrition (GS. Elvira Gonzalez de Mejia) &#8211; frontiersin.org<\/li>\n\n\n\n<li>Coffee Melanoidins as Antioxidant Dietary Fiber &#8211; Frontiers in Nutrition (TS. Maria Dolores del Castillo) &#8211; frontiersin.org<\/li>\n\n\n\n<li>Caffeinated and Decaffeinated Coffee and Type 2 Diabetes Risk: A Dose-Response Meta-Analysis &#8211; PubMed \/ PLOS ONE &#8211; pubmed.ncbi.nlm.nih.gov<\/li>\n\n\n\n<li>Designing Coffee for Health: Bioactive H\u1ee3p ch\u1ea5ts and Chronic Disease &#8211; MDPI (Dr. Adriana Farah) &#8211; mdpi.com<\/li>\n\n\n\n<li>Activating Effects of Coffee By-Product Bioactives on FGF21 Signaling in Liver Cells &#8211; Frontiers in Nutrition &#8211; frontiersin.org<\/li>\n\n\n\n<li>Chlorogenic Acid Degradation During Roasting &#8211; Food Chemistry (GS. Adriana Farah) &#8211; sciencedirect.com<\/li>\n\n\n\n<li>Cafestol and Kahweol in Coffee Brewing: Filtration and Cholesterol Effects &#8211; Food Research International (TS. S. Moeenfard) &#8211; sciencedirect.com<\/li>\n\n\n\n<li>Chlorogenic Acid Intake Through Coffee Consumption: Quantitative Estimates &#8211; MDPI (GS. Adriana Farah) &#8211; mdpi.com<\/li>\n<\/ul>\n\n\n\n<script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"C\u00e0 ph\u00ea decaf c\u00f3 mang l\u1ea1i l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe t\u01b0\u01a1ng \u0111\u01b0\u01a1ng c\u00e0 ph\u00ea th\u01b0\u1eddng kh\u00f4ng?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"C\u00e0 ph\u00ea decaf v\u1eabn gi\u1eef tr\u1ecdn h\u1ea7u h\u1ebft axit chlorogenic, melanoidin v\u00e0 trigonelline d\u00f9 \u0111\u00e3 lo\u1ea1i b\u1ecf ph\u1ea7n l\u1edbn caffeine. Do \u0111\u00f3, c\u00e1c l\u1ee3i \u00edch v\u1ec1 chuy\u1ec3n h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 gan h\u1ea7u nh\u01b0 \u0111\u01b0\u1ee3c b\u1ea3o to\u00e0n nguy\u00ean v\u1eb9n, trong khi t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh (v\u1ed1n ph\u1ee5 thu\u1ed9c nhi\u1ec1u v\u00e0o caffeine) c\u00f3 ph\u1ea7n nh\u1eb9 h\u01a1n. N\u1ebfu b\u1ea1n nh\u1ea1y c\u1ea3m v\u1edbi ch\u1ea5t k\u00edch th\u00edch, decaf l\u00e0 s\u1ef1 l\u1ef1a ch\u1ecdn tuy\u1ec7t v\u1eddi m\u00e0 kh\u00f4ng ph\u1ea3i hy sinh \u0111a s\u1ed1 l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe c\u1ee7a c\u00e0 ph\u00ea.\"}},{\"@type\":\"Question\",\"name\":\"Th\u00eam s\u1eefa ho\u1eb7c kem b\u00e9o c\u00f3 ph\u00e1 h\u1ee7y c\u00e1c h\u1ee3p ch\u1ea5t ho\u1ea1t t\u00ednh sinh h\u1ecdc kh\u00f4ng?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Protein trong s\u1eefa c\u00f3 th\u1ec3 li\u00ean k\u1ebft t\u1ea1m th\u1eddi v\u1edbi c\u00e1c polyphenol nh\u01b0 axit chlorogenic v\u00e0 l\u00e0m ch\u1eadm kh\u1ea3 n\u0103ng h\u1ea5p thu t\u1ea1i ru\u1ed9t, nh\u01b0ng c\u00e1c b\u1eb1ng ch\u1ee9ng v\u1ec1 vi\u1ec7c \u0111i\u1ec1u n\u00e0y l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 s\u1ee9c kh\u1ecfe l\u00e2u d\u00e0i v\u1eabn ch\u01b0a \u0111\u1ed3ng nh\u1ea5t \u2014 nhi\u1ec1u nghi\u00ean c\u1ee9u cho th\u1ea5y c\u00e1c polyphenol n\u00e0y v\u1eabn \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng v\u00e0 h\u1ea5p thu t\u1ed1t trong qu\u00e1 tr\u00ecnh ti\u00eau h\u00f3a sau \u0111\u00f3. H\u00e3y y\u00ean t\u00e2m th\u01b0\u1edfng th\u1ee9c ly c\u00e0 ph\u00ea s\u1eefa n\u1ebfu \u0111\u00f3 l\u00e0 s\u1edf th\u00edch c\u1ee7a b\u1ea1n.\"}},{\"@type\":\"Question\",\"name\":\"C\u00e0 ph\u00ea \u1ee7 l\u1ea1nh (Cold Brew) c\u00f3 gi\u1eef \u0111\u01b0\u1ee3c nhi\u1ec1u ho\u1ea1t ch\u1ea5t h\u01a1n c\u00e0 ph\u00ea pha n\u00f3ng?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Cold brew th\u01b0\u1eddng chi\u1ebft xu\u1ea5t \u0111\u01b0\u1ee3c \u00edt axit chlorogenic h\u01a1n c\u00e1c c\u00e1ch pha n\u00f3ng v\u00ec \u0111\u1ed9 h\u00f2a tan c\u1ee7a CGA t\u0103ng theo nhi\u1ec7t \u0111\u1ed9 n\u01b0\u1edbc, do \u0111\u00f3 l\u01b0\u1ee3ng polyphenol thu \u0111\u01b0\u1ee3c m\u1ed7i ly th\u01b0\u1eddng th\u1ea5p h\u01a1n d\u00f9 th\u1eddi gian \u1ee7 l\u00e2u h\u01a1n. \u0110i\u1ec3m c\u1ed9ng c\u1ee7a cold brew l\u00e0 \u0111\u1ed9 chua th\u1ea5p h\u01a1n, d\u1ec5 ch\u1ecbu cho d\u1ea1 d\u00e0y \u2014 nh\u01b0ng x\u00e9t ri\u00eang v\u1ec1 n\u1ed3ng \u0111\u1ed9 ho\u1ea1t ch\u1ea5t CGA, c\u00e0 ph\u00ea pha n\u00f3ng l\u1ecdc gi\u1ea5y v\u1eabn nh\u1ec9nh h\u01a1n.\"}},{\"@type\":\"Question\",\"name\":\"U\u1ed1ng vi\u00ean th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng chi\u1ebft xu\u1ea5t c\u00e0 ph\u00ea c\u00f3 mang l\u1ea1i t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 gan t\u01b0\u01a1ng t\u1ef1 kh\u00f4ng?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Chi\u1ebft xu\u1ea5t c\u00e0 ph\u00ea xanh c\u00f3 th\u1ec3 cung c\u1ea5p axit chlorogenic, nh\u01b0ng hi\u1ec7u \u1ee9ng ma tr\u1eadn t\u1ef1 nhi\u00ean \u2014 s\u1ef1 t\u01b0\u01a1ng h\u1ed7 gi\u1eefa CGA, melanoidin, trigonelline v\u00e0 c\u00e1c vi ch\u1ea5t kh\u00e1c \u2014 ho\u00e0n to\u00e0n bi\u1ebfn m\u1ea5t trong c\u00e1c vi\u00ean u\u1ed1ng \u0111\u01a1n l\u1ebb. C\u00e1c d\u1eef li\u1ec7u b\u1ea3o v\u1ec7 gan \u0111\u01b0\u1ee3c x\u00e2y d\u1ef1ng d\u1ef1a tr\u00ean th\u00f3i quen u\u1ed1ng c\u00e0 ph\u00ea nguy\u00ean b\u1ea3n, do \u0111\u00f3 vi\u00ean u\u1ed1ng b\u1ed5 sung kh\u00f4ng th\u1ec3 thay th\u1ebf ho\u00e0n to\u00e0n m\u1ed9t t\u00e1ch c\u00e0 ph\u00ea th\u1ef1c th\u1ee5.\"}},{\"@type\":\"Question\",\"name\":\"C\u00e0 ph\u00ea h\u00f2a tan c\u00f3 ph\u1ea3i l\u00e0 ngu\u1ed3n cung c\u1ea5p ho\u1ea1t ch\u1ea5t sinh h\u1ecdc t\u1ed1t kh\u00f4ng?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"C\u00e0 ph\u00ea h\u00f2a tan v\u1eabn gi\u1eef \u0111\u01b0\u1ee3c l\u01b0\u1ee3ng axit chlorogenic \u0111\u00e1ng k\u1ec3 \u2014 th\u01b0\u1eddng dao \u0111\u1ed9ng t\u1eeb 50\u2013150 mg m\u1ed7i t\u00e1ch \u2014 v\u00ec n\u00f3 \u0111\u01b0\u1ee3c ch\u1ebf bi\u1ebfn t\u1eeb c\u00e0 ph\u00ea pha nguy\u00ean ch\u1ea5t s\u1ea5y phun ho\u1eb7c s\u1ea5y l\u1ea1nh. \u0110\u00e2y v\u1eabn l\u00e0 ngu\u1ed3n ho\u1ea1t ch\u1ea5t sinh h\u1ecdc h\u1ee3p l\u1ec7, d\u00f9 h\u00e0m l\u01b0\u1ee3ng CGA th\u01b0\u1eddng th\u1ea5p h\u01a1n c\u00e0 ph\u00ea pha m\u1edbi v\u00e0 c\u00f3 th\u1ec3 ch\u1ee9a nhi\u1ec1u acrylamide h\u01a1n do ph\u1ea3i qua nhi\u1ec1u c\u00f4ng \u0111o\u1ea1n x\u1eed l\u00fd nhi\u1ec7t.\"}},{\"@type\":\"Question\",\"name\":\"H\u00e0m l\u01b0\u1ee3ng ho\u1ea1t ch\u1ea5t sinh h\u1ecdc c\u00f3 thay \u0111\u1ed5i theo v\u00f9ng tr\u1ed3ng hay gi\u1ed1ng h\u1ea1t kh\u00f4ng?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"C\u00f3, v\u00e0 kh\u00e1c bi\u1ec7t r\u1ea5t l\u1edbn. H\u1ea1t Robusta ch\u1ee9a h\u00e0m l\u01b0\u1ee3ng axit chlorogenic cao g\u1ea7n g\u1ea5p \u0111\u00f4i so v\u1edbi Arabica. \u0110\u1ed9 cao v\u00f9ng tr\u1ed3ng, th\u1ed5 nh\u01b0\u1ee1ng v\u00e0 ph\u01b0\u01a1ng ph\u00e1p s\u01a1 ch\u1ebf \u0111\u1ec1u t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn l\u01b0\u1ee3ng CGA trong h\u1ea1t c\u00e0 ph\u00ea nh\u00e2n. \u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a hai t\u00e1ch c\u00e0 ph\u00ea rang nh\u1ea1t t\u1eeb hai v\u00f9ng \u0111\u1ea5t kh\u00e1c nhau c\u00f3 th\u1ec3 mang l\u1ea1i nh\u1eefng h\u1ed3 s\u01a1 polyphenol ho\u00e0n to\u00e0n kh\u00e1c bi\u1ec7t.\"}},{\"@type\":\"Question\",\"name\":\"Ng\u01b0\u1eddi m\u1eafc ti\u1ec3u \u0111\u01b0\u1eddng type 2 c\u00f3 n\u00ean u\u1ed1ng c\u00e0 ph\u00ea \u0111\u1ec3 c\u1ea3i thi\u1ec7n chuy\u1ec3n h\u00f3a kh\u00f4ng?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"D\u1eef li\u1ec7u d\u1ecbch t\u1ec5 h\u1ecdc v\u1ec1 ph\u00f2ng ng\u1eeba ti\u1ec3u \u0111\u01b0\u1eddng l\u00e0 v\u00f4 c\u00f9ng nh\u1ea5t qu\u00e1n \u2014 c\u1ea3 c\u00e0 ph\u00ea th\u01b0\u1eddng l\u1eabn decaf \u0111\u1ec1u gi\u00fap gi\u1ea3m nguy c\u01a1 m\u1eafc b\u1ec7nh. Tuy nhi\u00ean, n\u1ebfu b\u1ea1n \u0111\u00e3 m\u1eafc b\u1ec7nh v\u00e0 \u0111ang d\u00f9ng thu\u1ed1c ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft, caffeine c\u00f3 th\u1ec3 g\u00e2y bi\u1ebfn \u0111\u1ed9ng \u0111\u01b0\u1eddng huy\u1ebft t\u1ee9c th\u1eddi trong ng\u1eafn h\u1ea1n. L\u1ee3i \u00edch chuy\u1ec3n h\u00f3a d\u00e0i h\u1ea1n l\u00e0 r\u1ea5t t\u00edch c\u1ef1c, nh\u01b0ng b\u1ea1n n\u00ean tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh l\u01b0\u1ee3ng caffeine ph\u00f9 h\u1ee3p.\"}},{\"@type\":\"Question\",\"name\":\"Kh\u1ea3 n\u0103ng ch\u1ed1ng oxy h\u00f3a c\u1ee7a c\u00e0 ph\u00ea c\u00f3 b\u1ecb m\u1ea5t \u0111i khi \u0111\u1ec3 trong b\u00ecnh gi\u1eef nhi\u1ec7t nhi\u1ec1u gi\u1edd?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Axit chlorogenic are relatively stable at room temperature over several hours, but the antioxidant capacity of brewed coffee does decline with prolonged exposure to heat and oxygen. Keeping coffee on a heated plate or in a hot thermos for more than a couple of hours measurably degrades polyphenol content - brewing fresh, or storing in a sealed insulated container at room temperature, preserves more bioactive activity.\"}}]}<\/script>\n\n\n\n<script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"BlogPosting\",\"@id\":\"https:\/\/coffeefactz.com\/coffee-bioactive-compound-groups\/#richSnippet\",\"about\":{\"@type\":\"Thing\",\"name\":\"Coffee bioactive compounds\"},\"mentions\":[{\"@type\":\"Thing\",\"name\":\"Caffeine\",\"sameAs\":\"https:\/\/www.google.com\/search?kgmid=\/m\/01_7l\"},{\"@type\":\"Thing\",\"name\":\"Trigonelline\",\"sameAs\":\"https:\/\/www.google.com\/search?kgmid=\/m\/05z0y_\"},{\"@type\":\"Thing\",\"name\":\"Cafestol\",\"sameAs\":\"https:\/\/www.google.com\/search?kgmid=\/m\/06f6r1\"},{\"@type\":\"Thing\",\"name\":\"Kahweol\",\"sameAs\":\"https:\/\/www.google.com\/search?kgmid=\/m\/04f60k4\"},{\"@type\":\"Thing\",\"name\":\"Oxidative stress\",\"sameAs\":\"https:\/\/www.google.com\/search?kgmid=\/m\/06qhr2\"},{\"@type\":\"Thing\",\"name\":\"Glucose uptake\",\"sameAs\":\"https:\/\/www.google.com\/search?kgmid=\/m\/0dq302\"}]}]}<\/script>\n","protected":false},"excerpt":{"rendered":"<p>C\u00e1c nh\u00f3m h\u1ee3p ch\u1ea5t ho\u1ea1t t\u00ednh sinh h\u1ecdc trong c\u00e0 ph\u00ea kh\u00f4ng ch\u1ec9 mang l\u1ea1i s\u1ef1 t\u1ec9nh t\u00e1o t\u1ee9c th\u00ec t\u1eeb caffeine \u2014 ch\u00fang v\u1eadn h\u00e0nh nh\u01b0 m\u1ed9t h\u1ec7 th\u1ed1ng h\u00f3a h\u1ecdc \u0111\u1ed3ng b\u1ed9 gi\u00fap k\u00edch ho\u1ea1t l\u00e1 ch\u1eafn b\u1ea3o v\u1ec7 t\u1ebf b\u00e0o, \u0111i\u1ec1u h\u00f2a chuy\u1ec3n h\u00f3a gan v\u00e0 gi\u1ea3m thi\u1ec3u nguy c\u01a1 m\u1eafc nhi\u1ec1u b\u1ec7nh m\u1ea1n t\u00ednh. Hi\u1ec3u r\u00f5 t\u1eebng h\u1ee3p ch\u1ea5t v\u00e0 c\u00e1ch qu\u00e1 tr\u00ecnh rang hay pha ch\u1ebf \u0111\u1ecbnh h\u00ecnh l\u1ea1i ch\u00fang l\u00e0 \u0111i\u1ec1u c\u1ea7n thi\u1ebft cho b\u1ea5t k\u1ef3 ai quan t\u00e2m \u0111\u1ebfn s\u1ee9c 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Toan","author_link":"https:\/\/coffeefactz.com\/vi\/author\/pham-toan\/"},"uagb_comment_info":0,"uagb_excerpt":"C\u00e1c nh\u00f3m h\u1ee3p ch\u1ea5t ho\u1ea1t t\u00ednh sinh h\u1ecdc trong c\u00e0 ph\u00ea kh\u00f4ng ch\u1ec9 mang l\u1ea1i s\u1ef1 t\u1ec9nh t\u00e1o t\u1ee9c th\u00ec t\u1eeb caffeine \u2014 ch\u00fang v\u1eadn h\u00e0nh nh\u01b0 m\u1ed9t h\u1ec7 th\u1ed1ng h\u00f3a h\u1ecdc \u0111\u1ed3ng b\u1ed9 gi\u00fap k\u00edch ho\u1ea1t l\u00e1 ch\u1eafn b\u1ea3o v\u1ec7 t\u1ebf b\u00e0o, \u0111i\u1ec1u h\u00f2a chuy\u1ec3n h\u00f3a gan v\u00e0 gi\u1ea3m thi\u1ec3u nguy c\u01a1 m\u1eafc nhi\u1ec1u&hellip;","_links":{"self":[{"href":"https:\/\/coffeefactz.com\/vi\/wp-json\/wp\/v2\/posts\/54031","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/coffeefactz.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/coffeefactz.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/coffeefactz.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/coffeefactz.com\/vi\/wp-json\/wp\/v2\/comments?post=54031"}],"version-history":[{"count":1,"href":"https:\/\/coffeefactz.com\/vi\/wp-json\/wp\/v2\/posts\/54031\/revisions"}],"predecessor-version":[{"id":54036,"href":"https:\/\/coffeefactz.com\/vi\/wp-json\/wp\/v2\/posts\/54031\/revisions\/54036"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/coffeefactz.com\/vi\/wp-json\/wp\/v2\/media\/51171"}],"wp:attachment":[{"href":"https:\/\/coffeefactz.com\/vi\/wp-json\/wp\/v2\/media?parent=54031"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/coffeefactz.com\/vi\/wp-json\/wp\/v2\/categories?post=54031"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/coffeefactz.com\/vi\/wp-json\/wp\/v2\/tags?post=54031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}